A5056336840- Adenosine and Purinergic Signaling
- Neurological Complications and Syndromes
- Neonatal and fetal brain pathology
- Neuroscience and Neuropharmacology Research
- Neuroscience of respiration and sleep
- Epilepsy research and treatment
- Pharmacological Receptor Mechanisms and Effects
- Cannabis and Cannabinoid Research
- Ion channel regulation and function
- Neonatal Health and Biochemistry
- EEG and Brain-Computer Interfaces
- Adolescent and Pediatric Healthcare
- Memory and Neural Mechanisms
- Sleep and Wakefulness Research
- Restless Legs Syndrome Research
- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Pharmacological Effects and Toxicity Studies
- Genetics and Neurodevelopmental Disorders
- Neonatal Respiratory Health Research
- Infectious Encephalopathies and Encephalitis
- Autoimmune Neurological Disorders and Treatments
- Fetal and Pediatric Neurological Disorders
Inserm
2023-2024
Centre National de la Recherche Scientifique
2023-2024
Université Claude Bernard Lyon 1
2023-2024
Centre de Recherche en Neurosciences de Lyon
2023-2024
Royal College of Surgeons in Ireland
2018-2023
Translational Research in Oncology
2023
Institut de l’Elevage
2023
Science Foundation Ireland
2020-2022
University of Alberta
2006
The purinergic ATP-gated P2X7 receptor (P2X7R) is increasingly recognized to contribute pathological neuroinflammation and brain hyperexcitability. P2X7R expression has been shown be increased in the brain, including both microglia neurons, experimental models of epilepsy patients. To date, cell type-specific downstream effects P2X7Rs during seizures remain, however, incompletely understood.
Neonatal seizures represent a clinical emergency. However, current anti-seizure medications fail to resolve in ~50% of infants. The P2X7 receptor (P2X7R) is an important driver inflammation, and evidence suggests that P2X7R contributes epilepsy adults. no genetic proof has yet been provided determine what contribution makes neonatal seizures, its effects on inflammatory signalling during the therapeutic potential P2X7R-based treatments long-lasting brain excitability.Neonatal were induced by...
Purinergic signalling via P2 receptors is now widely accepted to play a critical role during increased states of hyperexcitability and seizure-induced pathology. In the setting seizures epilepsy, most attention has been paid investigating fast-acting ATP-gated P2X receptor family. More recent evidence also provided compelling an involvement slower-acting P2Y family seizures. This includes data demonstrating expression changes in hippocampus following acute epilepsy anticonvulsive properties...
The P2X7 receptor (P2X7R) is an important contributor to neuroinflammation, responding extracellularly released adenosine triphosphate. Expression of the P2X7R increased in brain experimental and human epilepsy, genetic or pharmacologic targeting can reduce seizure frequency severity preclinical models. Experimentally induced seizures also increase levels blood. Here, we tested 18 F-JNJ-64413739, a positron emission tomography (PET) antagonist, as potential noninvasive biomarker...
Because of its involvement in breathing control and neuronal excitability, dysregulation the serotonin (5-HT) 2C receptor (5-HT2C) might play a key role sudden unexpected death epilepsy. Seizure-induced respiratory arrest is thus prevented by 5-HT2B/C agonist different seizure model. However, specific contribution 5-HT2C chronic epilepsy-related dysfunction remains unknown. In rat model temporal lobe epilepsy (EPI rats), which we previously reported interictal dysfunctions reduction...
Background: Evidence suggests that earlier diagnosis and initiation of treatment immediately after birth is critical for improved neurodevelopmental outcomes following neonatal encephalopathy (NE). Current diagnostic tests are, however, mainly restricted to clinical with no molecular available. Purines including adenosine are released during brain injury such as hypoxia also present in biofluids. Whether blood purine changes can be used diagnose NE has not been investigated date. Methods:...
Background and Purpose Neonatal seizures are a clinical emergency. Current anti-seizure medications, however, fail to resolve in ~50% of infants. The P2X7 receptor (P2X7R) is an important driver inflammation evidence suggest P2X7R contributing epilepsy adults. To date, no genetic proof has been provided determine the contribution neonatal seizures, its effects on inflammatory signalling during therapeutic potential P2X7R-based treatments long-lasting brain excitability. Experimental Approach...