A5040351944- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Infant Development and Preterm Care
- Traumatic Brain Injury and Neurovascular Disturbances
- Optical Imaging and Spectroscopy Techniques
- Non-Invasive Vital Sign Monitoring
- EEG and Brain-Computer Interfaces
- Cardiac Arrest and Resuscitation
- Pediatric Pain Management Techniques
- Anesthesia and Neurotoxicity Research
- Immune Cell Function and Interaction
- Pharmacological Effects and Toxicity Studies
- Mitochondrial Function and Pathology
- Heart Rate Variability and Autonomic Control
- Genomic variations and chromosomal abnormalities
- Genetics and Neurodevelopmental Disorders
- Fetal and Pediatric Neurological Disorders
- Congenital heart defects research
- Infectious Encephalopathies and Encephalitis
- Ion Transport and Channel Regulation
- Iterative Learning Control Systems
- Sulfur Compounds in Biology
- Congenital Heart Disease Studies
- Retinoids in leukemia and cellular processes
Infant
2019-2024
University College Cork
2019-2024
Cork University Hospital
2019-2024
Semmelweis University
2024
Centre Hospitalier Universitaire Sainte-Justine
2022
Université de Montréal
2022
KU Leuven
2022
Universitair Ziekenhuis Leuven
2022
RELX Group (United States)
2019
Despite the availability of continuous conventional electroencephalography (cEEG), accurate diagnosis neonatal seizures is challenging in clinical practice. Algorithms for decision support recognition could improve detection. We aimed to assess diagnostic accuracy an automated seizure detection algorithm called Algorithm Neonatal Seizure Recognition (ANSeR).
ObjectiveTo assess the impact of time to treatment first electrographic seizure on subsequent burden and describe overall management in a large neonatal cohort.Study designNewborns (36-44 weeks gestation) requiring electroencephalographic (EEG) monitoring recruited 2 multicenter European studies were included. Infants who received antiseizure medication exclusively after onset grouped based seizure: within 1 hour, between hours, hours. Outcomes measured burden, maximum status epilepticus,...
BackgroundDespite extensive research on neonatal hypoxic-ischaemic encephalopathy, detailed information about electrographic seizures during active cooling and rewarming of therapeutic hypothermia is sparse. We aimed to describe temporal evolution determine whether there a correlation seizure with 2-year outcome.MethodsThis secondary analysis included newborn infants recruited from eight European tertiary intensive care units for two multicentre studies (a randomised controlled trial...
To assess if early clinical and electroencephalography (EEG) features predict later seizure development in infants with hypoxic-ischemic encephalopathy (HIE).
Abstract Background Infants with mild HIE are at risk of significant disability follow-up. In the pre-therapeutic hypothermia (TH) era, electroencephalography (EEG) within 6 hours birth was most predictive outcome. This study aims to identify and describe features early EEG heart rate variability (HRV) (<6 age) in infants compared healthy term infants. Methods >36 weeks HIE, not undergoing TH, before age were identified from 4 prospective cohort studies conducted Cork University...
Background and aims Heart rate variability (HRV) has previously been assessed as a biomarker for brain injury prognosis in neonates. The aim of this cohort study was to use HRV predict the electroencephalography (EEG) grade neonatal hypoxic-ischaemic encephalopathy (HIE) within first 12 h. Methods We included 120 infants with HIE recruited part two European multi-centre studies, electrocardiography (ECG) EEG monitoring performed before h age. features background were using earliest 1 epoch...
Abstract The present study was designed to test the potential utility of regional cerebral oxygen saturation (rcSO 2 ) in detecting term infants with brain injury. also examined whether quantitative rcSO features are associated grade hypoxic ischaemic encephalopathy (HIE). We analysed 58 HIE (>36 weeks gestational age) enrolled a prospective observational study. All newborn had period continuous monitoring and magnetic resonance imaging (MRI) assessment during first week life. Signals...
Abstract Aim To investigate the effect of a musical intervention on neonatal stress response to venepuncture as measured by salivary cortisol levels and pain profile scores. Methods In randomised control crossover trial, participants were both arm (sucrose) (sucrose music) for routine procedures. Salivary swabs collected at baseline, 20 minutes post‐venepuncture 4 hours post‐venepuncture. Pain assessed using Premature Infant Profile (PIPP). A total 16 preterm neonates participated in arms...
To describe early cerebral oxygenation (cSO2 ) and fractional tissue oxygen extraction (FTOE) values their evolution over the first days of life in infants with all grades hypoxic-ischaemic encephalopathy (HIE) to determine whether cSO2 FTOE measured (6 12 h) can predict short-term outcome.Prospective, observational study near-infrared spectroscopy (NIRS) >36 weeks' gestation HIE. Ten one-hour epochs were extracted for each infant 84 h. Infants moderate severe HIE received therapeutic...
To describe early, continuous, non-invasive measures of cardiac output (CO) and evolution over time in infants with hypoxic-ischaemic encephalopathy (HIE).
Background: Evidence suggests that earlier diagnosis and initiation of treatment immediately after birth is critical for improved neurodevelopmental outcomes following neonatal encephalopathy (NE). Current diagnostic tests are, however, mainly restricted to clinical with no molecular available. Purines including adenosine are released during brain injury such as hypoxia also present in biofluids. Whether blood purine changes can be used diagnose NE has not been investigated date. Methods:...
BACKGROUND AND OBJECTIVE: Preterm neonates with intraventricular hemorrhage (IVH) are at risk for posthemorrhagic ventricular dilatation (PHVD).In recent years targeted proteomics has developed into a powerful protein quantifi cation tool in biomedical research, systems biology, and clinical applications.This study aims to inform therapeutic decision-making parental counseling using this high-risk group. METHODS:In prospective study, we investigated preterm born <34 weeks of gestation...
<b><i>Objective:</i></b> The use of noninvasive monitoring neonatal hemodynamics is increasing in care. Methods include cardiac output estimated by electrical cardiometry (EC) and peripheral perfusion as index (PI) using pulse oximetry. Our aim was to evaluate the feasibility continuously monitor preterm infants with EC PI during first 2 postnatal days effects averaging data signal quality (SigQ) analysis. <b><i>Design:</i></b> Prospective...
<h3>Background</h3> Music therapy may be beneficial for relieving pain associated with Neonatal Intensive Care Unit procedures. The aim of this study was to assess the effect music on EEG and HRV premature infants during painful <h3>Methods</h3> This a randomised crossover in newborns delivered before 32weeks gestational age (GA). Infants were receive initially either sucrose or (Brahms' lullaby) routine venepuncture. had multichannel recorded procedure, ECG part montage. Three 2-minute...
Isolated sulfite oxidase deficiency (ISOD) is a rare autosomal recessive neuro-metabolic disorder caused by mutation in the (SUOX) gene situated on chromosome 12. Due to of this mitochondrial enzyme (sulfite oxidase), oxidative degradation toxic sulfites disrupted. The most common form disease has an early onset (classical ISOD) neonatal period, with hypotonia, poor feeding and intractable seizures, mimicking hypoxic-ischaemic encephalopathy. evolution rapidly progressive severe...
<h3>Introduction</h3> Intraventricular haemorrhage (IVH) occurs in up to 15–20% of babies born before 32 weeks, and 30% less than 28 weeks gestation. Injury can cause detrimental short long-term health outcomes. Heart rate variability (HRV) is a measure autonomic function controlled by cardiorespiratory reflexes. Depressions decelerations HRV are sometimes witnessed clinically with acute central nervous system injury, such as haemorrhage. <h3>Aim</h3> This study aims describe prognostic tool...
<h3>Background</h3> Cerebral auto-regulation(CAR) in the preterm infant is a complex, multi-factorial process which still poorly characterised very infants. It plays substantial role aetiology of intraventricular haemorrhage (IVH). Studies typically examine relationship between cerebral oxygenation measured using near-infrared spectroscopy(NIRS) and mean arterial blood pressure(MABP) as method to study CAR impairment. <h3>Objective</h3> To explore more comprehensive, multi-modal analysis for...
<ns4:p>Pallister Killian Syndrome (PKS) is a rare genetic disorder caused by mosaic tetrasomy of the short arm chromosome 12. The syndrome characterised typical craniofacial dysmorphism, congenital anomalies and intellectual disability. Epilepsy known complication, with onset usually occurring in early childhood most commonly spasms myoclonic seizures. To best our knowledge, there have been no cases describing neonatal EEG PKS electrographic seizures, to date. Here, we report two presenting...
Hypoxic ischaemic encephalopathy (HIE), an important complication of perinatal asphyxia, remains a major health burden.Neonates are classifi ed using the Sarnat score and neonates >35 weeks with moderate/ severe HIE treated therapeutic hypothermia (TH).TH improves survival/ decreases disability however 30-50% mild cases (not offered TH) develop cognitive impairment.Early biomarkers vital to redefi ne better manage these infants.Cerebral monitoring is essential establish cerebral activity,...