A5032457721- Optical Imaging and Spectroscopy Techniques
- Non-Invasive Vital Sign Monitoring
- Hemodynamic Monitoring and Therapy
- Photoacoustic and Ultrasonic Imaging
- Neonatal and fetal brain pathology
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced NMR Techniques and Applications
- Electron Spin Resonance Studies
- Healthcare Technology and Patient Monitoring
- Congenital Heart Disease Studies
- Atomic and Subatomic Physics Research
- Enzyme Structure and Function
- Advanced MRI Techniques and Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Cardiovascular Health and Disease Prevention
- Anesthesia and Neurotoxicity Research
- Force Microscopy Techniques and Applications
- NMR spectroscopy and applications
- Analytical Chemistry and Sensors
- Photonic and Optical Devices
- Molecular spectroscopy and chirality
- Neonatal Respiratory Health Research
- Integrated Circuits and Semiconductor Failure Analysis
California University of Pennsylvania
2025
University of Pennsylvania
2025
Athinoula A. Martinos Center for Biomedical Imaging
2020-2022
Massachusetts General Hospital
2020-2022
Harvard University
2020-2022
KU Leuven
2022
Université de Montréal
2022
Cliniques Universitaires Saint-Luc
2022
University of Rochester
2021
Significance: The ability of diffuse correlation spectroscopy (DCS) to measure cerebral blood flow (CBF) in humans is hindered by the low signal-to-noise ratio (SNR) method. This limits high acquisition rates needed resolve dynamic changes and optimally filter out large pulsatile oscillations prevents use source-detector separations ( ≥3 cm ), which are achieve adequate brain sensitivity most adult subjects. Aim: To substantially improve SNR, we have built a DCS device that operates at 1064...
Rice-sized (1 × 4 mm) silicon nitride ring resonator photonic sensor chips paired with plastic micropillar fluidic cards for sample handling and optical detection yield a “disposable photonics” assay platform.
Hyperpolarized (HP) MRI using [1-13C]pyruvate is emerging as a promising molecular imaging approach. Among hyperpolarization methods, Signal Amplification By Reversible Exchange (SABRE) attractive because SABRE polarizes the substrates directly in room-temperature solutions avoiding complex hardware. Most experiments have historically been performed methanol, relatively toxic and difficult to remove solvent. Here we first demonstrate use of acetone-water-solvent system (Ace-SABRE) provide...
Hyperpolarized (HP) MRI using [1‐13C]pyruvate is emerging as a promising molecular imaging approach. Among hyperpolarization methods, Signal Amplification By Reversible Exchange (SABRE) attractive because SABRE polarizes the substrates directly in room‐temperature solutions avoiding complex hardware. Most experiments have historically been performed methanol, relatively toxic and difficult to remove solvent. Here we demonstrate use of 80/20 acetone‐water‐solvent system (Ace‐SABRE) provide...
Hyperpolarized (HP) MRI using [1‐13C]pyruvate is emerging as a promising molecular imaging approach. Among hyperpolarization methods, Signal Amplification By Reversible Exchange (SABRE) attractive because SABRE polarizes the substrates directly in room‐temperature solutions avoiding complex hardware. Most experiments have historically been performed methanol, relatively toxic and difficult to remove solvent. Here we demonstrate use of 80/20 acetone‐water‐solvent system (Ace‐SABRE) provide...
Real-time noninvasive monitoring of cerebral blood flow (CBF) during surgery is key to reducing mortality rates associated with adult cardiac surgeries requiring hypothermic circulatory arrest (HCA). We explored a method monitor different brain protection techniques using diffuse correlation spectroscopy (DCS), optical technique which, combined frequency-domain near-infrared (FDNIRS), also provides measure oxygen metabolism.
Time-domain diffuse correlation spectroscopy (TD-DCS) offers a novel approach to high-spatial resolution functional brain imaging based on the direct quantification of cerebral blood flow (CBF) changes in response neural activity. However, signal-to-noise ratio (SNR) offered by previous TD-DCS instruments remains challenge achieving high temporal needed resolve perfusion during measurements. Here we present next-generation optimized system that combines custom 1,064 nm pulse-shaped, quasi...
Currently, there is great interest in making neuroimaging widely accessible and thus expanding the sampling population for better understanding preventing diseases. The use of wearable health devices has skyrocketed recent years, allowing continuous assessment physiological parameters patients research cohorts. While most wearables monitor heart, lungs skeletal muscles, targeting brain are currently lacking. To promote general population, we developed a novel, low-cost wireless cerebral...
Abstract In premature infants with an extremely low gestational age (ELGA, < 29 weeks GA), dysregulated changes in cerebral blood flow (CBF) are among the major pathogenic factors leading to germinal matrix/intraventricular hemorrhage (GM/IVH). Continuous monitoring of CBF can guide interventions minimize risk brain injury, but there no clinically standard techniques or tools for its measurement. We report feasibility continuous CBF, including measures autoregulation, via diffuse...
Objective: This pilot study aims to show the feasibility of noninvasive and real-time cerebral hemodynamic monitoring during carotid endarterectomy (CEA) via diffuse correlation spectroscopy (DCS) near-infrared (NIRS). Methods: Cerebral blood flow index (CBFi) was measured unilaterally in seven patients bilaterally seventeen DCS. In fourteen patients, hemoglobin oxygenation changes were simultaneously NIRS. autoregulation (CAR) cerebrovascular resistance (CVR) estimated using CBFi arterial...
Carotid endarterectomy (CEA) involves removal of plaque in the carotid artery to reduce risk stroke and improve cerebral perfusion. This study aimed investigate utility assessing pulsatile blood volume flow during CEA. Using a combined near-infrared spectroscopy/diffuse correlation spectroscopy instrument, hemodynamics were assessed 12 patients undergoing Alterations amplitude, pulse transit time, beat morphology observed measurements ipsilateral surgical side. The additional information...
Dynamic nuclear polarization magnetic resonance spectroscopic imaging (DNP-MRSI) of hyperpolarized carbon-13 (HP 13C) is an exciting new technique that provides valuable information about the metabolism disease states. Though there are many substrates can be used to investigate in a variety models, application this technology often requires custom radiofrequency (RF) coil design. Furthermore, different coils within same project may provide results. In study, we utilized 3D printing molds...
Motivation: While hyperpolarized 1-13C Pyruvate Magnetic Resonance Spectroscopy holds great promise for in vivo profiling of cellular metabolism, the molecular alterations underlying observed metabolic phenotypes (metabotypes) remain understudied. Goal(s): We sought to characterize features contributing metabotypes identified on Hyperpolarized MRS hepatocellular carcinoma (HCC). Approach: integrated transcriptomic and proteomic together with HCC patient-derived xenografts (PDX) that...
Carotid endarterectomy (CEA) is a prophylactic operation to remove plaques inside carotid arteries, during which the patients are at high risk of embolic stroke. CEA performed bifurcation, where arteries cross-clamping in order isolate from circulation. However, there has been no gold standard for monitoring blood flow CEA. Here, we aimed investigate changes index (CBFi) and hemoglobin oxygenation with combined frequency-domain near-infrared spectroscopy (FDNIRS) diffuse correlation (DCS)...
We use diffuse correlation spectroscopy to safely quantify cerebral blood flow response spontaneous fluctuations in autonomic and respiratory activities help characterize the elevated risk of intraventricular hemorrhage extremely premature newborns.
Abstract Real-time noninvasive monitoring of cerebral blood flow during surgery could improve the morbidity and mortality rates associated with hypothermic circulatory arrests (HCA) in adult cardiac patients. In this study, we used a combined frequency domain near-infrared spectroscopy (FDNIRS) diffuse correlation (DCS) system to measure oxygen saturation (SO 2 ) an index (CBF i 12 adults going under HCA. Our measurements revealed that negligible amount is delivered brain HCA retrograde...
Cerebral blood flow monitoring is crucial during hypothermic circulatory arrest for aortic arch surgery. This study uses diffuse optics to demonstrate simultaneous of cerebral and oxygen saturation
Hypoxic ischaemic encephalopathy (HIE), an important complication of perinatal asphyxia, remains a major health burden.Neonates are classifi ed using the Sarnat score and neonates >35 weeks with moderate/ severe HIE treated therapeutic hypothermia (TH).TH improves survival/ decreases disability however 30-50% mild cases (not offered TH) develop cognitive impairment.Early biomarkers vital to redefi ne better manage these infants.Cerebral monitoring is essential establish cerebral activity,...
Impaired cerebral autoregulation (CA) in premature infants leads to Intraventricular hemorrhage (IVH). A DCS-derived index of CA has shown its association with IVH. Further stratification by hsPDA may explain the variation No-IVH group.
To promote brain health, we developed a low-cost wireless wearable cerebral oximeter with sampling rate of 266 Hz, using multi-distance self-calibration probe geometry. It was validated on phantoms and human participants (n=5) against frequency-domain NIRS.
Real-time noninvasive cerebral blood flow monitoring during cardiac surgery could decrease rates of neurologic injury associated with hypothermic circulatory arrests (HCA). We used combined frequency domain near-infrared spectroscopy and diffuse correlation (FDNIRS-DCS) to measure oxygen saturation an index (CBFi) in 12 adults undergoing HCA. Our measurements revealed negligible CBFi retrograde perfusion (RCP: 91.2%±3.3% drop; HCA-only: 95.5%±1.8% drop). There was a significant difference...
In this paper, we demonstrated a superconductive sensing-based system for cerebral blood flow monitoring via diffuse correlation spectroscopy at 1064nm. Findings show high brain sensitivity and fast using the presented system.