A5001570772- Asymmetric Synthesis and Catalysis
- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Analysis
- RNA and protein synthesis mechanisms
- Proteoglycans and glycosaminoglycans research
- Synthetic Organic Chemistry Methods
- Cyclopropane Reaction Mechanisms
- Biochemical and Molecular Research
- Glycosylation and Glycoproteins Research
- DNA and Nucleic Acid Chemistry
- Enzyme Catalysis and Immobilization
- Synthesis and Catalytic Reactions
- Catalytic C–H Functionalization Methods
- Fluorine in Organic Chemistry
- Antibiotic Resistance in Bacteria
- Crystallization and Solubility Studies
- Synthesis and biological activity
- X-ray Diffraction in Crystallography
- Chemical Synthesis and Reactions
- Oxidative Organic Chemistry Reactions
- Bacterial Genetics and Biotechnology
- Advanced Drug Delivery Systems
- RNA Interference and Gene Delivery
- HIV/AIDS drug development and treatment
- Microbial Metabolic Engineering and Bioproduction
Instituto de Química Orgánica General
2014-2025
Consejo Superior de Investigaciones Científicas
2006-2023
Universidad Complutense de Madrid
2019
Universidad de Zaragoza
2000-2010
University of Florence
2003-2010
Universidad de La Rioja
2008-2010
Instituto de Química Física Blas Cabrera
2008-2010
Centro de Investigaciones Biológicas Margarita Salas
2007-2008
University of Göttingen
2006
Institute for the Chemistry of OrganoMetallic Compounds
2005
Enveloped viruses enter cells by binding to receptors present on host cell membranes, which trigger internalization and membrane fusion. For many viruses, this either directly or indirectly involves interaction with membrane-anchored carbohydrates, such as heparan sulfate, providing a potential target for broad-spectrum antiviral approach. Based hypothesis, we screened library of functionalized chitosan sulfates that mimic sulfate in cellular membranes inhibition SARS-CoV-2 respiratory...
Aminoglycoside antibiotics participate in a large variety of binding processes involving both RNA and proteins. The description, recent years, several clinically relevant aminoglycoside/receptor complexes has greatly stimulated the structural-based design new bioactive derivatives. Unfortunately, efforts have frequently met with limited success, reflecting our incomplete understanding molecular determinants for antibiotic recognition. Intriguingly, aromatic rings protein/RNA receptors seem...
[reaction: see text] A novel and simple procedure for reduction of hydroxylamines to the corresponding amines by means indium powder in aqueous media is reported. Applicability one-pot reactions isoxazolidine N-O bond also demonstrated. catalytic version process using 2-5% In presence other metals (Zn, Al) has been successfully developed.
Sulfation of molecules in living organisms is a process that plays key role their functionality. In mammals, the sulfation polysaccharides (glycosaminoglycans) form proteoglycans present extracellular matrix particularly important. These polysaccharides, through degree and pattern, are involved variety biological events as signal modulators communication processes between cell its environment. Because this great importance, there growing interest development efficient sustainable processes,...
Aminoglycosides are clinically relevant antibiotics that participate in a large variety of molecular recognition processes involving different RNA and protein receptors. The 3-D structures these policationic oligosaccharides play key role binding therefore determine their biological activity. Herein, we show the particular NH2/NH3+/OH distribution within antibiotic scaffold modulates oligosaccharide conformation flexibility. In particular, those polar groups flanking glycosidic linkages have...
Hydrogels with controlled degradation and sustained antibiofilm activity are promising biomaterials for the treatment of oral infections such as periodontitis or caries. In this article, an
Abstract A new total synthesis of (2 S ,3 R )‐3‐hydroxy‐3‐methylproline has been performed via a key intermediate chiral pyrroline N ‐oxide, obtained from ( )‐citramalic acid. This nitrone underwent nucleophilic addition furyllithium with complete stereoselectivity through preferential attack anti to the methoxymethoxy group. The correct stereochemistry was established an oxidation−reduction sequence, which allowed inversion configuration at C‐2. (© Wiley‐VCH Verlag GmbH & Co. KGaA,...
A complete characterisation of the protonation equilibrium that accompanies molecular recognition neomycin-B by a specific RNA receptor has been achieved employing simple NMR measurements.
The synthesis of enantiopure cyclic nitrones has become a frequently addressed topic in discussions their usefulness the production natural products and biologically active compounds. This emphasis stimulated development variety synthetic approaches that are described this review, organized on basis size nitrone ring.
Chondroitin sulfates are linear anionic sulfated polysaccharides found in biological tissues, mainly within the extracellular matrix, which degraded and altered by specific lyases depending on time points. These have recently acquired relevance pharmaceutical industry due to their interesting therapeutic applications. As a consequence, chondroitin sulfate (CS) been widely investigated as tools for development of new pharmaceuticals based these polysaccharides. This review focuses major...
Brain-derived neurotrophic factor (BDNF) regulates dendritic branching and spine morphology, as well synaptic plasticity long-term potentiation. Consequently, BDNF deficiency has been associated with some neurological disorders such Alzheimer's, Parkinson's or Huntington's diseases. In contrast, elevated levels correlate recovery after traumatic central nervous system (CNS) injuries. The utility of a therapeutic agent is limited by its short half-life in pathological microenvironment low...
[reaction: see text] The two-step metal-catalyzed overall transformation of isoxazolidine-5-spirocyclopropanes into the corresponding dihydro- and tetrahydropyridones is described. first step chemoselective reduction N-O bond isoxazolidine ring preserving fragile cyclopropanol moiety while second Pd(II) or Pd(0) conversion beta-aminocyclopropanol derivatives final compounds. scope limitations this strategy are
Controlling chondroitin sulfates (CSs) biological functions to exploit their interesting potential biomedical applications requires a comprehensive understanding of how the specific sulfate distribution along polysaccharide backbone can impact in activities, still challenging issue. To this aim, herein, we have applied an “holistic approach” recently developed by us look globally within CS disaccharide epitopes direct binding these polysaccharides growth factors. do this, analyzed several...