A5036206864- Advanced Chemical Sensor Technologies
- Enzyme Production and Characterization
- Nanocomposite Films for Food Packaging
- Photochemistry and Electron Transfer Studies
- Enzyme Catalysis and Immobilization
- Gas Sensing Nanomaterials and Sensors
- Surfactants and Colloidal Systems
- Glycosylation and Glycoproteins Research
- Proteoglycans and glycosaminoglycans research
- Proteins in Food Systems
- Analytical Chemistry and Chromatography
- Protein Structure and Dynamics
- Olfactory and Sensory Function Studies
- Enzyme Structure and Function
- Carbohydrate Chemistry and Synthesis
- Spectroscopy and Quantum Chemical Studies
- Advanced Drug Delivery Systems
- Protein Kinase Regulation and GTPase Signaling
- Diet, Metabolism, and Disease
- Connective tissue disorders research
- Protease and Inhibitor Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Hydrogels: synthesis, properties, applications
- Phytoestrogen effects and research
- Analytical Methods in Pharmaceuticals
Universidad Complutense de Madrid
2012-2023
Instituto de Síntesis Química y Catálisis Homogénea
2021
Universidad de Zaragoza
2021
Hospital Central de la Defensa Gómez Ulla
2013-2014
European Molecular Biology Laboratory
2000
Magnetic iron oxide nanoparticles (MION) for protein binding and separation were obtained from water-in-oil (w/o) oil-in-water (o/w) microemulsions. Characterization of the prepared have been performed by TEM, XRD, SQUID magnetometry, BET. Microemulsion-prepared magnetic (ME-MION) with sizes ranging 2 to 10 nm obtained. Study on properties at 300 K shows a large increase magnetization ~35 emu/g w/o-ME-MION superparamagnetic behavior nanoscale dimensions in comparison o/w-ME-MION (10 emu/g)...
Lung cancer (LC) is the leading cause of death in men and second women worldwide. The use low-dose computed tomography early diagnosis was shown to reduce mortality by 20% with a median follow-up time 6.5 years. In order increase profitability radiation risks costs, exhaled biomarkers could serve help establish narrower inclusion criteria. aim this study identify new, well-founded volatile organic compounds breath which distinguish LC patients from chronic obstructive pulmonary disease...
Dextran aldehyde (dexOx), resulting from the periodate oxidative cleavage of 1,2-diol moiety inside dextran, is a polymer that very useful in many areas, including as macromolecular carrier for drug delivery and other biomedical applications. In particular, it has been widely used chemical engineering enzymes, with aim designing better biocatalysts possess improved catalytic properties, making them more stable and/or active different reactions. This possesses flexible hydrophilic structure,...
Room temperature ionic liquids (ILs) can affect enzyme activity in some enzyme-catalyzed reactions, however the effects of these cosolvents on enzymes are not clearly understood. Using β-galactosidase from Thermus thermophilus HB27 (TTP0042), we found an important change classical regioselectivity transglycosylation reaction with this enzyme. The increases N-acetyl-D-lactosamine synthesis (Galβ[1→4]GlcNAc) when RTILs used instead traditional self-condensated products. To understand possible...
Brain-derived neurotrophic factor (BDNF) regulates dendritic branching and spine morphology, as well synaptic plasticity long-term potentiation. Consequently, BDNF deficiency has been associated with some neurological disorders such Alzheimer's, Parkinson's or Huntington's diseases. In contrast, elevated levels correlate recovery after traumatic central nervous system (CNS) injuries. The utility of a therapeutic agent is limited by its short half-life in pathological microenvironment low...
In this work, two chitosan samples from cuttlebone and squid pen are produced characterized. We studied the formation of thermoresponsive hydrogels with β-glycerol phosphate found proper formulations that form at 37 °C. Gel depended on source being possible to produce concentration 1% but 1.5% was needed for pen. For first time, these non-commercial sources have been used in combination prepare risperidone controlled drug delivery. Three types risperidone-controlled release developed,...
Abstract Pleckstrin1 is a major substrate for protein kinase C in platelets and leukocytes, comprises central DEP (disheveled, Egl‐10, pleckstrin) domain, which flanked by two PH (pleckstrin homology) domains. domains display unique α/β fold have been implicated membrane binding utilizing different mechanisms. Using multiple sequence alignments phylogenetic tree reconstructions, we find that 6 subfamilies of the domain exist, pleckstrin represents novel distinct subfamily. To clarify...
A green synthesis for β-(1→3) galactosyldisaccharides that combines the use of a biodegradable biocatalyst, aqueous solutions, and solvent recycling (renewable derived from biomass) has been developed. The biomass-derived solvents allows good catalytic activity in Gal-β-D-(1→3)GlcNAc Gal-β-D-(1→)3GalNAc (99% 95% yields respectively) with β-Gal-3-NTag β-galactosidase, preventing hydrolytic full regioselectivity. This represents considerable improvement over an buffer or conventional organic...
In this report, we focus our attention on the characterization of 2,2,2-trifluoroethanol(TFE)/H2O mixtures and describe their intrinsic parameters; i.e., solvent acidity (SA), basicity (SB), dipolarity/polarizability (SPP), by probe/homomorph-couple method for a range from 0–100% (v/v) TFE. Variation these parameters is not linear has singular unpredictable behavior depending precise composition mixture. Based parameters, TFE-induced changes in some physical properties; viscosity (η),...
Chitosan sulfates have demonstrated the ability to mimic heparan sulfate (HS) function. In this context, it is crucial understand how specific structural properties of HS domains determine their functionalities and biological activities. study, several HS-mimicking chitosans been prepared structure that proved be functionally significant in cell processes. The results presented herein are concordance with hypothesis sulfated chitosan–growth factor (GF) interactions controlled by a...
Solvent acidity (SA), solvent basicity (SB), and dipolarity polarizability (SPP) parameters for urea water mixtures.