A5076105243- COVID-19 Clinical Research Studies
- Systemic Lupus Erythematosus Research
- Long-Term Effects of COVID-19
- Autoimmune and Inflammatory Disorders Research
- Influenza Virus Research Studies
- Platelet Disorders and Treatments
- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Advanced Drug Delivery Systems
- COVID-19 and Mental Health
- Hematological disorders and diagnostics
- Dermatological and COVID-19 studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immunodeficiency and Autoimmune Disorders
- Parvovirus B19 Infection Studies
- Nanocomposite Films for Food Packaging
- Hydrogels: synthesis, properties, applications
- Renal Diseases and Glomerulopathies
- Diabetes and associated disorders
Research Institute Hospital 12 de Octubre
2021-2024
Hospital Universitario 12 De Octubre
2022-2024
Universidad Complutense de Madrid
2022
The immune response type organized against viral infection is determinant in the prognosis of some infections. This work has aimed to study Th polarization acute COVID-19 and its possible association with outcome through an observational prospective study. Fifty-eight patients were recruited Medicine Department hospital “12 de Octubre,” 55 remaining after losses follow-up. Four groups established according maximum degree disease progression. T-helper cell percentages phenotypes, analyzed by...
The Th1/Th2 balance plays a crucial role in the progression of different pathologies and is determining factor evolution infectious diseases. This work has aimed to evaluate early, or on diagnosis, T-cell compartment response, T-helper subsets anti-SARS-CoV-2 antibody specificity COVID-19 patients classify them according based infection severity. A unicenter, randomized group 146 was divided into four groups accordance with most critical events during course disease. immunophenotype were...
Objective Patients with coronavirus disease 2019 (COVID‐19) present coagulation abnormalities and thromboembolic events that resemble antiphospholipid syndrome (APS). This work has aimed to study the prevalence of APS‐related antigens, antibodies, immune complexes in patients COVID‐19 their association clinical events. Methods A prospective was conducted on 474 adults severe acute respiratory 2 infection hospitalized two Spanish university hospitals. were evaluated for classic extra‐criteria...
Background Antiphospholipid syndrome (APS) is a multisystemic autoimmune disorder characterized by thrombotic events and/or gestational morbidity in patients with antiphospholipid antibodies (aPL). In previous single center study, APS-related clinical manifestations that were not included the classification criteria (livedo reticularis, thrombocytopenia, leukopenia) associated presence of circulating immune-complexes (CIC) formed beta-2-glycoprotein-I (B2GP1) and anti-B2GP1 (B2-CIC). We have...
Background: COVID-19 clinical features include a hypercoagulable state that resembles the antiphospholipid syndrome (APS), disease characterized by thrombosis and presence of antibodies (aPL). The relationship between aPL-presence appearance thrombi as well transience or permanence aPL in patients is not sufficiently clear. Methods: A group 360 were followed-up for 6 months. Classic aPL, anti-B2GPI IgA, anti-phosphatidylserine/prothrombin IgG/M anti-SARS-CoV-2 determined at acute phase...
In this work, two chitosan samples from cuttlebone and squid pen are produced characterized. We studied the formation of thermoresponsive hydrogels with β-glycerol phosphate found proper formulations that form at 37 °C. Gel depended on source being possible to produce concentration 1% but 1.5% was needed for pen. For first time, these non-commercial sources have been used in combination prepare risperidone controlled drug delivery. Three types risperidone-controlled release developed,...
Introduction Influenza virus infection can cause a range of clinical symptoms, including respiratory failure (RF) and even death. The mechanisms responsible for the most severe forms disease are not yet well understood. objective is to assess initial immune response upon admission its potential impact on progression. Methods We conducted prospective observational study patients with influenza who required tertiary hospital in 2017/18 2018/19 flu seasons. Immune markers, surrogate markers...
NK degranulation plays an important role in the cytotoxic activity of innate immunity clearance intracellular infections and is factor outcome disease. This work has studied immunological profiles functionalities COVID-19 patients its association with severity A prospective observational study 99 was conducted. Patients were grouped according to hospital requirements severity. Innate immune cell subpopulations analyzed. The profile functionality cells differ between healthy controls severe...
The presence of antiphospholipid antibodies (aPLs) is associated with syndrome (APS), characterized by thrombosis and obstetric morbidity. aPLs included in APS classification criteria are lupus anticoagulant, anti-cardiolipin anti-beta-2-glycoprotein-I IgG or IgM isotypes. Enzyme-linked immunosorbent assay the most used diagnostic technique to determine aPLs. Recently, new automated technologies mainly based antigen-coated beads have been developed. aim compare a fluorescence enzyme...