A5073639224- Systemic Lupus Erythematosus Research
- Platelet Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Renal Diseases and Glomerulopathies
- Renal Transplantation Outcomes and Treatments
- Diabetes and associated disorders
- COVID-19 Clinical Research Studies
- Dermatological and COVID-19 studies
- Lymphoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Plant Genetic and Mutation Studies
- Viral-associated cancers and disorders
- Organ Transplantation Techniques and Outcomes
- Plant tissue culture and regeneration
- Venous Thromboembolism Diagnosis and Management
- Systemic Sclerosis and Related Diseases
- Pulmonary Hypertension Research and Treatments
- Hepatitis C virus research
- Light effects on plants
- Liver physiology and pathology
- Cardiovascular Function and Risk Factors
- Phytochemical Studies and Bioactivities
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Alkaloids: synthesis and pharmacology
Research Institute Hospital 12 de Octubre
2017-2025
Hospital Universitario 12 De Octubre
2014-2025
Hospital Clínico San Carlos
1995-2023
Universitat de Barcelona
1984-2021
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2021
Complejo Hospitalario de Jaén
2019
Universidad Complutense de Madrid
2017
Fundación Ramón Domínguez
2017
Universidade da Coruña
2017
Universidad San Pablo CEU
2014
Seronegative antiphospholipid syndrome (SNAPS) is an autoimmune disease present in patients with clinical manifestations highly suggestive of Antiphospholipid Syndrome (APS) but persistently negative consensus antibodies (a-PL). IgA anti- β 2 Glycoprotein I (aB2-GPI) are associated APS. However, they not currently considered to be laboratory criteria due the heterogeneity published works and use poor standardized diagnostic systems. We have aimed assess aPL a group APS (C-APS) evaluate...
OBJECTIVE To assess the impact of a telemedicine visit using platform Diabetic compared with face-to-face on clinical outcomes, patients’ health-related quality life (HRQoL), and physicians’ satisfaction in patients type 1 diabetes. RESEARCH DESIGN AND METHODS PLATEDIAN (Telemedicine Metabolic Control Type Diabetes Mellitus Andalusian Patients) (NCT03332472) was multicenter, randomized, 6-month follow-up, open-label, parallel-group controlled study performed diabetes suboptimal metabolic...
In patients with hepatocellular carcinoma (HCC), increased myeloid-derived suppressor cells (MDSC) relate to aggressiveness and poor prognosis. Favorable responses immune checkpoint inhibitors demonstrate that HCC is susceptible activation, suggesting the elimination of MDSC would provide therapeutic benefits. However, a global analysis different subsets in still missing. Here we phenotyped circulating myeloid cell (monocytes, M-MDSC, PMN-MDSC eMDSC) by flow cytometry...
The experience of 22 Hodgkin's disease (HD) patients with human immunodeficiency virus type I (HIV) antibodies, collected from a cooperative study six hospitals during 1984-1989 is presented. Young men (average age, 27.6 years) high incidence intravenous drug abuse (86%) were found. status the HIV infection at diagnosis HD was: four patients, acquired immune deficiency syndrome (AIDS); eight persistent generalized lymphadenopathy (PGL); and ten asymptomatic. natural history was unusual, B...
Objective Patients with coronavirus disease 2019 (COVID‐19) present coagulation abnormalities and thromboembolic events that resemble antiphospholipid syndrome (APS). This work has aimed to study the prevalence of APS‐related antigens, antibodies, immune complexes in patients COVID‐19 their association clinical events. Methods A prospective was conducted on 474 adults severe acute respiratory 2 infection hospitalized two Spanish university hospitals. were evaluated for classic extra‐criteria...
Background The antiphospholipid syndrome (APS) is defined by simultaneous presence of vascular clinical events and antibodies (aPL). aPL considered as diagnostics are lupus anticoagulant anticardiolipin (aCL) anti-ß2 glycoprotein-I (aB2GP1). During recent years, IgA aB2GP1 have been associated with thrombotic both in patients positive, mainly negative for other aPL, however its value a pro-thrombotic risk-factor asymptomatic has not well defined. Objective To test the role anti B2GP1 risk...
Abstract Background: Early detection of antinuclear antibodies (ANA) in asymptomatic subjects is useful to predict autoimmune diseases years before diagnosis. ANA have been determined by indirect immunofluorescence (IIF) using human epithelial type 2 (HEp-2) cells, which considered the gold standard technique. Multiplex technology (BioPlex Screen) has introduced for evaluation recent years. Nevertheless, concordance between BioPlex and IIF low there no harmonization both methods...
Recurrent pregnancy loss (RPL) affects up to 6% of couples. Although chromosomal aberrations the embryos are considered leading cause, 50% cases remain unexplained. Antiphospholipid Syndrome is a known cause in few cases. antibodies (aPL) anticardiolipin, anti-Beta-2-Glycoprotein-I and Lupus Anticoagulant (criteria aPL) recommended studies RPL workup. We tested healthy women with unexplained for criteria aPL anti-Phosphatidylserine/Prothrombin (aPS/PT). Patients were classified into three...
IgA antibeta 2 Glycoprotein I (β2GPI) antibodies test can identify some patients with antiphospholipid syndrome (APS) that are negative for other isotypes. Controversy exists because studies have reported a strong association of these vascular disease, while others not confirmed this observation. Our hypothesis is contradictory results may be due to differences among commercial diagnostic kits. To answer question, we compared the obtained several most commonly used anti β2GPI (aβ2GPI) assays...
In the current immunosuppressive therapy era, vessel thrombosis is most common cause of early graft loss after renal transplantation. The prevalence IgA anti-β2-glycoprotein I antibodies (IgA-aB2GPI-ab) in patients on dialysis elevated (>30%), and these correlate with mortality cardiovascular morbidity. To evaluate effect IgA-aB2GPI-ab transplants, we followed all transplanted from 2000 to 2002 Hospital 12 de Octubre prospectively for 10 years. Presence pretransplant serum was examined...
Vessel thrombosis is a severe complication after renal transplantation. Antibodies anti-β-2 glycoprotein-I of IgA isotype (IgA-aB2GP1) have been linked to thrombotic events and mortality in hemodialysis patients.All kidney transplanted patients from 2000 2011 (n = 1375) our hospital were followed up for 2 years, evaluating 3 time periods.At transplantation, 401 positive IgA-aB2GPI (29.2%, group 1), the remaining negative (group 2). Graft loss at 6 months posttransplantation was higher 1 (18%...
IgA anti-beta2-glycoprotein I (IgA-aB2GPI) antibodies are currently not included as a laboratory criterion of antiphospholipid syndrome (APS). In the 13th International Congress on Antiphospholipid Antibodies, Galveston, TX, (USA) in 2010, these were accepted an APS patients who had clinical manifestations but negative for "consensus" (aPL) (IgG and IgM isotypes). Consequently, individuals with thrombotic events consensus aPL may be undiagnosed APS. The most recent publications have...
Aim: Antiphospholipid syndrome (APS) is characterized by recurrent thrombosis and/or gestational morbidity in patients with antiphospholipid autoantibodies (aPL). Over recent years, IgA anti-beta2-glycoprotein I (B2GPI) antibodies (IgA aB2GPI) have reached similar clinical relevance as IgG or IgM isotypes. We recently described the presence of immune complexes bounded to B2GPI (B2A-CIC) blood antecedents APS symptomalology. However, B2A-CIC's associations thrombotic events (TEV) not been yet.
Background Antiphospholipid syndrome (APS) is a multisystemic autoimmune disorder characterized by thrombotic events and/or gestational morbidity in patients with antiphospholipid antibodies (aPL). In previous single center study, APS-related clinical manifestations that were not included the classification criteria (livedo reticularis, thrombocytopenia, leukopenia) associated presence of circulating immune-complexes (CIC) formed beta-2-glycoprotein-I (B2GP1) and anti-B2GP1 (B2-CIC). We have...
Background: Antiphospholipid syndrome is characterized by recurrent thrombosis and gestational morbidity in patients with antiphospholipid autoantibodies (aPLs). Predictive value of the presence aPLs low, new markers are necessary to identify aPL carriers at higher risk take preventive measures on them. The circulating immune complexes IgA bound β 2 -glycoprotein I (B2A-CIC) has been associated occurrence acute thrombotic events. In this work we study its possible predictive for appearance...
Background: COVID-19 clinical features include a hypercoagulable state that resembles the antiphospholipid syndrome (APS), disease characterized by thrombosis and presence of antibodies (aPL). The relationship between aPL-presence appearance thrombi as well transience or permanence aPL in patients is not sufficiently clear. Methods: A group 360 were followed-up for 6 months. Classic aPL, anti-B2GPI IgA, anti-phosphatidylserine/prothrombin IgG/M anti-SARS-CoV-2 determined at acute phase...
IgA anti-beta-2-glycoprotein I (aB2GPI) antibodies have been related to vascular pathology in the general population and mainly hemodialyzed patients (prevalence 33%) whom an elevated incidence of thrombosis mortality is found. In this paper we studied presence aB2GPI at pretransplant their evolution after transplantation with a cross-sectional-based follow-up study cohort 288 endstage renal disease (ESRD) treated kidney transplantation. Pretransplant levels were elevated<mml:math...
Summary Introduction In recent years, we have been witnessing increased clinical interest in the determination of IgA anti‐beta 2‐glycoprotein I ( aB 2 GPI ) antibodies as well demand for this test. Some ELISA ‐based diagnostic systems detection are suboptimal to detect it. The aim our study was determine whether yield modern based on automatic platforms measure is equivalent that well‐optimized assays. Methods total, 130 patients were analyzed by three fully automated immunoassays using an...