A5091659685- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Pancreatic and Hepatic Oncology Research
- Organ Donation and Transplantation
- Liver Disease Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Clinical Nutrition and Gastroenterology
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal disorders and treatments
- Organ and Tissue Transplantation Research
- Hernia repair and management
- Appendicitis Diagnosis and Management
- Abdominal Surgery and Complications
- Esophageal and GI Pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Intraperitoneal and Appendiceal Malignancies
- Hepatocellular Carcinoma Treatment and Prognosis
- Neuroendocrine Tumor Research Advances
- Immune Cell Function and Interaction
- Biliary and Gastrointestinal Fistulas
- Hepatitis C virus research
Universidad Complutense de Madrid
2017-2025
Hospital Universitario 12 De Octubre
2016-2025
Research Institute Hospital 12 de Octubre
2015-2025
Organización Nacional de Trasplantes
2025
Centro de Investigación Biomédica en Red
2021-2024
Inserm
2024
Sorbonne Université
2024
Centre de Recherche Saint-Antoine
2024
V.I.Shumakov Federal Research Center of Transplantology and Artificial Organs
2023
Madrid Institute for Advanced Studies
2020
Abstract Background and aims Alpha-1 antitrypsin (AAT) is a product of SERPINA1 gene mainly expressed by hepatocytes. Clinically relevant mutations in the gene, such as Z (Glu342Lys), results an expression misfolded AAT protein having high propensity to polymerize, accumulate hepatocytes thus enhance risk for hepatocyte damage subsequent liver disease. So far, relationship between Z-AAT accumulation cell remains not completely understood. We present three-dimensional organoid culture...
Uncontrolled donation after circulatory death (uDCD) increases organ availability for kidney transplant (KT) with short-term outcomes similar to those obtained from brain (DBD) donors. However, heterogeneous results in the long term have been reported. We compared 10-year between 237 KT recipients uDCD donors maintained by normothermic extracorporeal membrane oxygenation (nECMO) and patients undergoing standard criteria DBD during same period at our institution. further analyzed risk factors...
One method for increasing the donor pool orthotopic liver transplantations (OLTs) is to use uncontrolled donation after circulation death (uDCDs).From January 2006 December 2016, we performed 75 OLTs using uDCD livers. The control group comprised a sample of 265 livers donations brain (DBDs). A comparative study was performed.Of 256 potential donors cannulated, (29.3%) were accepted OLT. amount hemoderivatives transfused significantly higher in group. rate primary nonfunction also (P =...
Background: There is controversy regarding which the best reconstruction technique after pancreatoduodenectomy. Currently, there are no studies comparing three most frequent techniques: Whipple + Roux-en-Y gastrojejunostomy (WRYGJ), pyloric-preserving Billroth II (PPBII), and BII (WBII). Methods: Between 2012 March 2023, 246 patients underwent pancreaticoduodenectomy with following type of (1) WRYGJ: 40 patients; (2) PPBII: 118 (3) WBII: 88 patients. A retrospective comparative study among...
Background Delayed gastric emptying (DGE) is a frequent complication of pancreatoduodenectomy (PD) and associated with prolonged hospital stay, readmission, increased costs decreased quality life. However, the pathophysiology DGE remains unclear.
Liver transplant recipients (LTR) have been considered a population group vulnerable to COVID-19 disease as they are chronically immunosuppressed patients with frequent comorbidities. This study describes the course of SARS-CoV-2 from February 2020 December 2023 along seven pandemic “waves". We carried out an observational on 307 cases cohort in LTR aim evaluating changes characteristics over time and determining risk factors for severe COVID-19. Older age serum creatinine ≥ 2 mg/dL...
The incidence of peptic perforation has not decreased despite the successful management Helicobacter pylori (HP), suggesting other mechanisms are involved in pathological process. Our findings support relevance Candida spp. these types perforations. These provide insight into perforations complicated by fungal infections and highlight importance routinely performing peritoneal culture biopsies patients. We propose that coinfection be considered an independent risk factor mortality patients...
Liver transplant recipients (LTRs) have been considered a population group that is vulnerable to COVID-19 as they are chronically immunosuppressed patients with frequent comorbidities. This study describes the course of SARS-CoV-2 disease from February 2020 December 2023 along seven pandemic "waves". We carried out an observational on 307 cases in cohort LTRs aim evaluating changes characteristics over time and determining risk factors for severe COVID-19. An older age serum creatinine level...
Switching the use of calcineurin inhibitors (CNIs), as basal immunosuppression in liver transplantation (LT) patients, for that mycophenolate mofetil monotherapy (MMF-MT) is currently considered a good measure recipients with chronic kidney disease (CKD) and other CNI-related adverse effects. We analyzed retrospective cohort series 324 LT patients who underwent long-term follow-up were switched from CNI to MMF-MT due CKD effects (diabetes, hypertension, infection). The median time on was 78...
In patients with hepatocellular carcinoma (HCC), increased myeloid-derived suppressor cells (MDSC) relate to aggressiveness and poor prognosis. Favorable responses immune checkpoint inhibitors demonstrate that HCC is susceptible activation, suggesting the elimination of MDSC would provide therapeutic benefits. However, a global analysis different subsets in still missing. Here we phenotyped circulating myeloid cell (monocytes, M-MDSC, PMN-MDSC eMDSC) by flow cytometry...
We examined intraepithelial lymphocytes (IELs) in 213 ileal biopsies from 16 bowel grafts and compared them with 32 native intestines. During the first year posttransplantation, exhibited low levels of IELs (percentage CD103+ cells) principally due to reduced CD3+CD8+ cells, while CD103+CD3– cell numbers became significantly higher. Changes IEL subsets did not correlate histology results, isolated intestine, or multivisceral transplants, but CD3– were higher patients receiving...
Different mutations in the SERPINA1 gene result alpha-1 antitrypsin (AAT) deficiency and an increased risk for development of liver diseases. More than 90% severe patients are homozygous Z (Glu342Lys) mutation. This mutation causes Z-AAT polymerization intrahepatic accumulation which can hepatic alterations leading to steatosis, fibrosis, cirrhosis, and/or hepatocarcinoma. We aimed investigate lipid status hepatocytes carrying normal M alleles gene. Hepatic organoids were developed...
Children are one of the groups with highest mortality rate on waiting list for LT. Primary closure abdominal wall is often impossible in pediatric population, due to a size mismatch between large graft and small recipient. We present retrospective cohort study six patients, who underwent delayed biological mesh after LT, whom early was impossible. A non-cross-linked porcine-derived acellular dermal matrix (Strattice(™) Reconstructive Tissue Matrix; LifeCell Corp, Bridgewater, NJ, USA) used...
Which are the consequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in liver transplant (LT) recipients?We attempted to address this question by reviewing our single-center experience during first months pandemics at a high incidence area.Nineteen adult patients (5 females) were diagnosed May 5, 2020. Median age was 58 (range 55-72), and median follow-up since transplantation 83 20-183) months. Cough (84.2%), fever (57.9%), dyspnea (47.4%) most common...
Whether immunosuppression impairs severe acute respiratory syndrome coronavirus 2-specific T cell-mediated immunity (SARS-CoV-2-CMI) after liver transplantation (LT) remains unknown. We included 31 LT recipients in whom SARS-CoV-2-CMI was assessed by intracellular cytokine staining (ICS) and interferon (IFN)-γ FluoroSpot assay a median of 103 days from COVID-19 diagnosis. Serum SARS-CoV-2 IgG antibodies were measured ELISA. A control group nontransplant immunocompetent patients matched (1:1...