A5051717127- Ion Channels and Receptors
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Pain Mechanisms and Treatments
- Ion channel regulation and function
- Neuropeptides and Animal Physiology
- Nerve injury and regeneration
- Adenosine and Purinergic Signaling
- Herbal Medicine Research Studies
- RNA regulation and disease
- RNA and protein synthesis mechanisms
- Endometrial and Cervical Cancer Treatments
- RNA Research and Splicing
- Epigenetics and DNA Methylation
Etna Biotech (Italy)
2024
University of Florence
2022-2023
University of Siena
2020-2021
The MODOMICS database has been, since 2006, a manually curated and centralized resource, storing distributing comprehensive information about modified ribonucleosides. Originally, it only contained data on the chemical structures of ribonucleosides, their biosynthetic pathways, location residues in RNA sequences, RNA-modifying enzymes. Over years, prompted by accumulation new knowledge types data, been updated with functionalities. In this release, we have created catalog modifications...
Insulin growth factor-1 (IGF-1), an osteoclast-dependent osteolysis biomarker, contributes to metastatic bone cancer pain (MBCP), but the underlying mechanism is poorly understood. In mice, femur metastasis caused by intramammary inoculation of breast cells resulted in IGF-1 increase and sciatic nerve, IGF-1-dependent stimulus/non-stimulus-evoked pain-like behaviors. Adeno-associated virus-based shRNA selective silencing receptor (IGF-1R) Schwann cells, not dorsal root ganglion (DRG)...
Background and Purpose The pro‐algesic transient receptor potential ankyrin 1 (TRPA1) channel, expressed by a subpopulation of primary sensory neurons, has been implicated in various pain models mice. However, evidence rats indicates that TRPA1 conveys nociceptive signals elicited channel activators, but not those associated with tissue inflammation or nerve injury. Here, rats, we explored the role mechanical allodynia stimulation peptidergic neurons (neurogenic inflammation) moderate...
Analgesia by non-steroidal anti-inflammatory drugs (NSAIDs) is ascribed to inhibition of prostaglandin (PG) biosynthesis and ensuing inflammation. However, NSAIDs have life-threatening side effects, inflammation delays pain resolution. Decoupling the mechanisms underlying PG-evoked vs. protective would facilitate treatment. Herein, we reveal that selective silencing PGE2 EP2 receptor in Schwann cells via an adeno-associated viral vector abrogates indomethacin-sensitive component pain-like...
Background and Purpose. The proalgesic transient receptor potential (TRP) ankyrin 1 (TRPA1) channel, expressed by a subpopulation of primary sensory neurons, has been implicated in various pain models mice. However, evidence rats indicates that TRPA1 conveys nociceptive signals elicited channel agonists but not those associated with tissue inflammation or nerve injury. Here, rats, we explored the role mechanical allodynia neurogenic moderate (partial sciatic ligation, pSNL) severe (chronic...