Dopamine (DA) is one of the main neurotransmitters found in central nervous system and has a vital role function dopaminergic (DArgic) neurons. A progressive loss this specific subset cells hallmarks age-related neurodegenerative disorders such as Parkinson's disease (PD). Symptomatic therapy for PD been centered precursor l-DOPA administration, an amino acid DA that crosses blood-brain barrier (BBB) while does not, although approach presents medium- to long-term side effects. To overcome...

Abstract Functionalization of nanoparticles can significantly influence their properties and potential applications. Although researchers now functionalize metal, metal oxide, organic polymer with a high degree precision, controlled surface functionalization nanoscale coordination particles (CPPs) has remained significant challenge. The lack methodology is perhaps one the greatest roadblocks to advancement CPPs into added‐value drug delivery Here, we report having achieved this goal through...

A versatile and highly efficient strategy to construct a xanthone skeleton via ligand-free intermolecular catalytic coupling of 2-substituted benzaldehydes wide range phenols has been developed. For this purpose, novel magnetically recoverable catalyst consisting copper nanoparticles on nanosized silica coated maghemite is presented. The reaction proceeds smoothly with easy recovery reuse the catalyst. methodology compatible various functional groups provides an attractive protocol for...

We report the use of bis-catecholic polymers as candidates for obtaining effective, tunable gatekeeping coatings mesoporous silica nanoparticles (MSNs) intended drug release applications. In monomers, catechol rings act adhesive moieties and reactive sites polymerization, together with middle linkers which may be chosen to tune physicochemical properties resulting coating. Stable low-toxicity (pNDGA pBHZ) were prepared from two bis-catechols different polarity (NDGA BHZ) on MSN carriers...

Hollow polymeric polydopamine (PDA) micro-/nanocapsules have been obtained through a very simple, mild, and straightforward method that involves coating of silica mesoporous nanoparticles an ammonia-triggered polymerization PDA the posterior removal sacrificial template simply by dispersion in water, without need any harsh chemical reagent, either presence or absence active principles, from doxorubicin to iron oxide nanoparticles. To demonstrate potential nanocapsules with this new approach,...

New amorphous coordination polymer particles (CPPs) based on bis-catechol ligands showed pH-tuned spin transition responses.

Abstract Die Anhaftung einiger mariner Organismen in nasser Umgebung an fast jede Art von Oberfläche hat den letzten Jahrzehnten zunehmendes Interesse geweckt. Zahlreiche Untersuchungen wurden durchgeführt, um die Grundlage für dieses Verhalten zu verstehen. Dabei wurde festgestellt, dass Catechol eine Schlüsselrolle spielt. Mithilfe des Wissens aus diesen Studien einige neuartige bioinspirierte Klebstoffe und Beschichtungen mit zusätzlichem Nutzen entwickelt. Bisher gab es noch keine...

Abstract The combination of the surface‐adhesive properties catechol rings and functional moieties conveying specific is very appealing to materials chemistry, but preparation derivatives often requires elaborate synthetic routes circumvent intrinsic reactivity ring. In this work, catechols are synthesized straightforwardly by using bioinspired reaction several thiols with o ‐benzoquinone. With one exception, conjugated addition thiol takes place regioselectively at 3‐position quinone,...

The hydrothiolation of activated alkynes is presented as an attractive and powerful way to functionalize thiols bearing catechols. reaction was promoted by a heterogeneous catalyst composed copper nanoparticles supported on TiO2 (CuNPs/TiO2) in 1,2-dichloroethane (1,2-DCE) under heating at 80 °C. could be recovered reused three consecutive cycles, showing slight decrease its catalytic activity. Thiol derivatives catechol moieties, obtained through versatile Michael addition, were reacted...

Abstract Under very mild reaction conditions, iron or copper nanoparticles efficiently promoted the homocoupling of different Grignard reagents in tetrahydrofuran at room temperature. The nanosized particles were generated situ a simple and economical way from commercially available FeCl2 CuCl2, respectively, an excess lithium powder, catalytic amount (5 mol%) 4,4′-di-tert-butylbiphenyl (DTBB) as electron carrier. series aryl, heteroaryl, benzyl, alkenyl presence substoichiometric led to...

Abstract Two rationally designed strategies for covalent bonding of fluorescent dyes in coordination polymer nanoparticles aiming to achieve bifunctional nanostructures have been developed. The first strategy was based on the synthesis polymers structured as by Co II ions two different catechol ligands containing free functional chemical groups (dopamine and 3,4‐dihydroxybenzaldehyde), a bis(imidazole)‐based ligand (1,4‐bis(imidazole‐1‐ylmethyl)benzene, bix). Subsequently, dyes, namely...

The synthesis and characterisation of new dyes based on indolizines bearing catechol groups in their structure is presented. preparation was carried out through a simple three component one-pot reaction promoted by CuNPs/C, between pyridine-2-carbaldehyde, an aromatic alkyne tetrahydroisoquinoline (THIQ) functionalized with groups. products were isolated 30%-34% yield, which considered more than acceptable considering that the hydroxyl not protected prior to reaction. In view colour...

The reaction of different terminal alkynes with readily prepared copper(0) nanoparticles led to the formation corresponding symmetrical 1,4-disubstituted 1,3-diynes in good yield. No palladium, ligands, or oxidant additives were needed. For aliphatic alkynes, use sodium carbonate as base markedly improved rate and allowed a substoichiometric amount copper nanoparticles.

The synthesis and structuration of a novel low-molecular-weight amphiphilic catechol compound is reported. combination hydrophilic tail containing unit pyrene-based hydrophobic head favors solvent-tuned supramolecular assembly. Formation hollow nanocapsules/vesicles occurs in concentrated solutions polar protic nonprotic organic solvents, whereas fibril-like aggregation process favored water, even at low concentrations. emission properties the pyrene moiety allow monitoring self-assembly...

Based on experimental results and DFT studies, a detailed reaction mechanism is presented for the CuNPs/TiO 2 -catalysed hydrothiolation of activated alkynes with thiols bearing catechol group.

High surface area cerium oxide (240 m²/g) efficiently promoted the Suzuki–Miyaura cross-coupling of aryl iodides with arylboronic acids, in absence palladium or any other ­transition-metal catalyst. Excellent selectivity towards product was observed. Cerium could be recovered and reused at least three times without loss activity.

Abstract Anionic ring‐opening polymerization (AROP) was employed for the controlled synthesis of linear model block copolymers 1,3,5,7‐tetrametil‐1,3,5,7‐tetravinyl(cyclotetrasiloxane) (V 4 ) and 1,3,5‐dimethyl(cyclotrisiloxane) (D 3 monomers by using sec ‐butyl lithium ( ‐Bu − Li + as initiator, high‐vacuum anionic techniques. V copolymerization promoted employing D producing living silanolates that open stable ring. For this purpose, two strategies were applied: (a) sequential addition...

Our study unveils an innovative methodology that merges catechols with mono- and disaccharides, yielding a diverse array of compounds. This strategic fusion achieves robust yields introduces ligands dual nature: encompassing both the chelating attributes recognition capabilities carbohydrates. synergistic design led us to couple one novel Fe(iii) salt, resulting in creation Coordination Glycopolymer Particles (CGPs). These CGPs demonstrate remarkable qualities, boasting outstanding...

The reaction of a series aldehydes and ketones with readily prepared cobalt or titanium nanoparticles, under mild conditions, led to the obtention different reductive dimerization products depending on nature transition metal used.Cobalt nanoparticles (CoNPs) allowed selective transformation starting carbonyl compounds into vicinal diols, whereas promoted by (TiNPs) formation corresponding alkenes.In this last case, use trimethylsilyl chloride (TMSCl) as additive, at 0 ºC, also diols after...