A5044694864- CRISPR and Genetic Engineering
- Urological Disorders and Treatments
- Genital Health and Disease
- Epigenetics and DNA Methylation
- Cervical Cancer and HPV Research
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Multiculturalism, Politics, Migration, Gender
- SARS-CoV-2 and COVID-19 Research
- Sarcoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Cell death mechanisms and regulation
- Viral gastroenteritis research and epidemiology
- Histone Deacetylase Inhibitors Research
- Animal Virus Infections Studies
- Genetics and Neurodevelopmental Disorders
- Machine Learning in Bioinformatics
- Cancer therapeutics and mechanisms
- Biotechnology and Related Fields
- Computational Drug Discovery Methods
- Ear and Head Tumors
- vaccines and immunoinformatics approaches
- Myasthenia Gravis and Thymoma
- Private Equity and Venture Capital
- Chronic Myeloid Leukemia Treatments
Universidade Federal do Ceará
2018-2024
Universidade de Fortaleza
2020
Universidade Federal do Rio de Janeiro
2018
National Institute of Science and Technology of Drugs and Medicines
2018
A pericardite tuberculosa (PT) é uma manifestação grave da tuberculose extrapulmonar, associada a altas taxas de morbimortalidade, especialmente em regiões com elevada prevalência e HIV. Apresenta-se sintomas inespecíficos, como febre sudorese noturna, pode evoluir para complicações graves, tamponamento cardíaco constritiva. Este estudo revisa os avanços diagnósticos terapêuticos PT, destacando desafios oportunidades no manejo. Testes moleculares, o Xpert MTB/RIF, técnicas avançadas imagem,...
A leucemia mieloide aguda (LMA) é uma neoplasia agressiva com alta mortalidade, particularmente em pacientes de alto risco. Avanços recentes no tratamento têm transformado a abordagem da doença, destaque para terapias direcionadas, como inibidores FLT3, IDH1/2 e menin, além combinações venetoclax agentes hipometilantes, que demonstraram altas taxas remissão, especialmente frágeis. Imunoterapias, o magrolimab CAR-T, também emergiram alternativas promissoras. Além disso, estratégias manutenção...
Penile squamous cell carcinoma (SCC) is a rare and aggressive tumour mainly related to lifestyle behaviour human papillomavirus (HPV) infection. Environmentally induced loss of imprinting (LOI) at the H19 differentially methylated region (H19DMR) associated with many cancers in early events tumorigenesis may be involved pathogenesis penile SCC. We sought evaluate DNA methylation pattern H19DMR its association HPV infection men SCC by bisulfite sequencing (bis-seq). observed an average 32.2%...
The imprinted H19 long non-coding RNA, a knowing oncofetal gene, presents controversial role during the carcinogenesis process since its tumor suppressor or oncogenic activity is not completely elucidated. Since lncRNA involved in many biological pathways related to tumorigenesis, we sought develop non-cancer lineage with CRISPR-Cas9-mediated knockdown (H19-) and observe changes cellular context. To edit promoter region of H19, two RNA guides were designed, murine C2C12 myoblast cells...
INTRODUCTION: Quantitative reverse transcription polymerase chain reaction (RT-qPCR) can detect the severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) in a highly specific manner. However, decrease specificity of PCR assays for their targets may lead to false negative results. METHODS: Here, 177 high-coverage complete SARS-CoV-2 genome sequences from 13 Brazilian states were aligned with 15 WHO recommended assays. RESULTS: Only 3 completely all sequences. Ten had mismatches up and...
Abstract Background Penile cancer is one of the most aggressive male tumors. Although it preventable, main etiologic causes are lifestyle behaviors and viral infection, such as human papillomavirus (HPV). Long-term epigenetic changes due to environmental factors change cell fate promote carcinogenesis, being an important marker prognosis. We evaluated epidemiological aspects penile squamous carcinoma (SCC) prevalence HPV infection using high-risk (hrHPV) p16 INK4A expression 224...
O sarcoma sinovial (SS) é uma neoplasia rara e agressiva de tecidos moles, frequentemente caracterizada pela translocação cromossômica SS18::SSX. Este trabalho tem como objetivo revisar os avanços terapêuticos recentes para o tratamento do SS, explorando estratégias inovadoras que incluem terapias-alvo, imunoterapia, modulação epigenética uso biomarcadores. A metodologia consistiu em análise sistemática literatura, com seleção artigos publicados entre 2019 2024, extraídos bases PubMed....