A5030299174- Galectins and Cancer Biology
- Cancer Mechanisms and Therapy
- Signaling Pathways in Disease
- Toxin Mechanisms and Immunotoxins
- Glycosylation and Glycoproteins Research
Brigham and Women's Hospital
2015-2022
Harvard University
2022
T-cell immunoglobulin mucin family member 3 (Tim-3) is an immune checkpoint receptor that dampens effector functions and causes terminal exhaustion of cytotoxic T cells. Tim-3 inhibitors are under investigation in immuno-oncology (IO) trials, because blockade T-cell-Tim-3 enhances antitumor immunity. Here, we identify additional role for as a growth-suppressive intrinsic to melanoma Inhibition cell-Tim-3 promoted tumor growth both immunocompetent immunocompromised mice, while...
<div>Abstract<p>T-cell immunoglobulin mucin family member 3 (Tim-3) is an immune checkpoint receptor that dampens effector functions and causes terminal exhaustion of cytotoxic T cells. Tim-3 inhibitors are under investigation in immuno-oncology (IO) trials, because blockade T-cell-Tim-3 enhances antitumor immunity. Here, we identify additional role for as a growth-suppressive intrinsic to melanoma Inhibition cell-Tim-3 promoted tumor growth both immunocompetent immunocompromised...
Supplementary Data from Inhibition of Melanoma Cell–Intrinsic Tim-3 Stimulates MAPK-Dependent Tumorigenesis
Supplementary Data from Inhibition of Melanoma Cell–Intrinsic Tim-3 Stimulates MAPK-Dependent Tumorigenesis
<div>Abstract<p>T-cell immunoglobulin mucin family member 3 (Tim-3) is an immune checkpoint receptor that dampens effector functions and causes terminal exhaustion of cytotoxic T cells. Tim-3 inhibitors are under investigation in immuno-oncology (IO) trials, because blockade T-cell-Tim-3 enhances antitumor immunity. Here, we identify additional role for as a growth-suppressive intrinsic to melanoma Inhibition cell-Tim-3 promoted tumor growth both immunocompetent immunocompromised...