A5090359879- Galectins and Cancer Biology
- Thermal Regulation in Medicine
- Advancements in Semiconductor Devices and Circuit Design
- Semiconductor materials and devices
- Cancer Mechanisms and Therapy
- Intensive Care Unit Cognitive Disorders
- Thermoregulation and physiological responses
- Signaling Pathways in Disease
- Facial Trauma and Fracture Management
- Dental Implant Techniques and Outcomes
- Dental Radiography and Imaging
- Glycosylation and Glycoproteins Research
- Sinusitis and nasal conditions
- Ferroelectric and Negative Capacitance Devices
- Anesthesia and Sedative Agents
- Bacterial biofilms and quorum sensing
- Digital Filter Design and Implementation
- Rice Cultivation and Yield Improvement
- Anesthesia and Neurotoxicity Research
- Vibrio bacteria research studies
- Phytochemical and Pharmacological Studies
- Surgical Sutures and Adhesives
- Nausea and vomiting management
- Agricultural Science and Fertilization
- Agricultural Systems and Practices
Max Planck Institute for Terrestrial Microbiology
2025
National Bureau of Plant Genetic Resources
2024
University of Delhi
2024
Guru Teg Bahadur Hospital
2024
University College of Medical Sciences
2024
Brigham and Women's Hospital
2022-2024
Harvard University
2022-2024
Post Graduate Institute of Medical Education and Research
2020-2022
Gandhi Medical College & Hospital
2021
Shree Krishna Hospital
2019-2021
Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer. Inhibitors targeting the programmed death 1 (PD-1) immune checkpoint have improved MCC patient outcomes by boosting antitumor T immunity. Here, we identify PD-1 as growth-promoting receptor intrinsic to cells. In human lines clinical tumors, RT-PCR–based sequencing, immunoblotting, flow cytometry, immunofluorescence analyses demonstrated gene protein expression MCC–PD-1 ligation enhanced, its inhibition or silencing...
We present GradeIT, a system that combines the dual objectives of automated grading and program repairing for introductory programming courses (CS1). Syntax errors pose significant challenge testcase-based as it is difficult to differentiate between submission almost correct has some minor syntax another completely off-the-mark. GradeIT also uses repair help in submissions do not compile. This enables running testcases on containing errors, thereby awarding partial marks these (which,...
Programmed cell death 1 (PD-1) is a premier cancer drug target for immune checkpoint blockade (ICB). Because PD-1 receptor inhibition activates tumor-specific T-cell immunity, research has predominantly focused on T-cell-PD-1 expression and its immunobiology. In contrast, cell-intrinsic functional regulation not well understood. Here, we demonstrate induction of in melanoma cells via type I interferon (IFNAR) signaling reversal ICB efficacy through IFNAR pathway inhibition. Treatment with...
This study was designed to find the minimum effective doses of doxapram and pethidine stop post‐anaesthetic shivering. Two hundred twenty healthy patients who shivered following routine surgery were allocated randomly receive one 10 (0.18, 0.23, 0.29, 0.35, 0.41, 0.47, 0.7, 0.93, 1.17 1.4 mg.kg −1 ), five (0.12, 0.18, 0.29 0.35 ) or saline. Probit analysis demonstrated that number stopped shivering with independent amount drug given in this dose range. The lowest (0.18 significantly more...
Abstract This study was planned to evaluate the improvement in mandibular function, facial esthetics and quality of life after reconstruction complex defects using patient-specific three-dimensional (3D) titanium implant. A total 7 patients, who visited our outpatient clinic for removal their primary lesion refused treatment with autologous bone grafts were treated implant mandible. Three-dimensional virtual planning carried out 3D computed-tomographic data. The unaffected contralateral side...
T-cell immunoglobulin mucin family member 3 (Tim-3) is an immune checkpoint receptor that dampens effector functions and causes terminal exhaustion of cytotoxic T cells. Tim-3 inhibitors are under investigation in immuno-oncology (IO) trials, because blockade T-cell-Tim-3 enhances antitumor immunity. Here, we identify additional role for as a growth-suppressive intrinsic to melanoma Inhibition cell-Tim-3 promoted tumor growth both immunocompetent immunocompromised mice, while...
Block outlier detection methods, based on Tietjen-Moore (TM) and Shapiro-Wilk (SW) tests, are proposed to detect suppress spectrum sensing data falsification (SSDF) attacks by malicious users in cooperative sensing. First, we consider basic statistical SSDF attacks, where the attack independently. Then propose a new attack, which involves cooperation among masking. In practice, number of is unknown. Thus, it necessary estimate users, found using clustering largest gap method. However, show...
Abstract Monoclonal antibodies (abs) targeting the programmed cell death 1 (PD-1) immune checkpoint pathway have revolutionized tumor therapy. Because T-cell-directed PD-1 blockade boosts immunity, anti-PD-1 abs been developed for examining T-cell-PD-1 functions. More recently, expression has also reported directly on cancer cells of various etiology, including in melanoma. Nevertheless, there is a paucity studies validating ab clone utility specific assay types characterizing cell-intrinsic...
Summary One hundred patients (69 female) undergoing surgical excision of three or more wisdom teeth were randomly allocated to receive either thiopentone propofol for induction anaesthesia. Other than the agent, anaesthetic regimen was standardised all cases. All observed 15 min after entry into recovery area assess presence and intensity shivering. Twenty‐five in group (n = 50) 11 shivered postoperatively (p < 0.005). There no statistically significant difference axillary temperature...
An efficient and reproducible method for transformation depends on the competency of organism. We have developed a simple preparation competent Escherichia coli, Kluyveromyces lactis, Bifidobacterium sp. by using buffer containing cetyl trimethyl ammonium bromide (CTAB) permits uptake plasmid DNA ligation-reaction products. Cells are harvested, washed, mixed with 1-10 μg/ml CTAB, incubated, followed wash. For long-term storage cells, bacteria may be frozen in 10% glycerol without addition...
A BSTRACT Aim: The current study was conducted to evaluate the influence of frequently ingested beverages on stability suture materials. Materials and Methods: This research comprised two kinds chromic catgut, polyglactin 910 (4-0) absorbable Every specimen subjected tying using a square surgeon’s knot. Subsequent pretensioning, 80 samples (40 every material) were employed in this research. immersion artificial saliva replicate oral atmosphere. Specimens sunken acidic drink (Coca Cola) tea...
The nickel base superalloy, supercast 247A gains its appropriate microstructure and high temperature strength through precipitation hardening mechanism. Because of their service conditions, tensile properties the alloy have strong influence on stability life turbine blades. Tensile fracture mechanisms cast heat treated superalloy were studied in ambient temperature, with a constant strain rate 0.1 mm per minute. Scanning electron microscopy was used to provide structural fractography...
In polar semiconductors conduction electrons can gain or lose both energy and momentum to the lattice by interacting with modes of vibrations. A simple method calculating average rate loss is proposed for case where may be treated as an infinite heat bath distribution known.
Abstract The diagnostic and therapeutic potential of Maackia amurensis agglutinin (MAA) have been reported in various malignancies. Earlier, we found that MAA specifically interacted with human non-small cell lung-cancer (NSCLC) cells induced apoptosis these cells. present study was designed to identify M. leukoagglutinin (MAL-I, one the components MAA, having same carbohydrate specificity as MAA) interacting membrane sialoglycoprotein(s) two subtypes NSCLC lines. Nine proteins were...