A5019834742- Bee Products Chemical Analysis
- Insect and Pesticide Research
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Meat and Animal Product Quality
- Plant and animal studies
- CRISPR and Genetic Engineering
Maurice Wilkins Centre
2024
University of Auckland
2024
University of Otago
2024
University of Waikato
2021-2023
Drug-resistant strains of Mycobacterium tuberculosis are a major global health problem. Resistance to the front-line antibiotic isoniazid is often associated with mutations in katG-encoded bifunctional catalase-peroxidase. We hypothesise that perturbed KatG activity would generate collateral vulnerabilities isoniazid-resistant katG mutants, providing potential pathway targets combat resistance. Whole genome CRISPRi screens, transcriptomics, and metabolomics were used genome-wide map cellular...
Abstract This study investigated the potential of utilising elemental fingerprinting honey to differentiate New Zealand (NZ) from that international origin. Twenty elements were analysed by ICP-MS in 352 honeys 34 various countries. Of these, 323 (245 honeys, 78 international) and two subsets data (NZ European origin, n = 306, and, NZ Denmark/Germany, 280) visualised using principal component analysis (PCA). For NZ/Europe subset, 42.2% was explained first components. Statistical...