A5026746807- Suicide and Self-Harm Studies
- Child and Adolescent Psychosocial and Emotional Development
- Metabolomics and Mass Spectrometry Studies
- Dementia and Cognitive Impairment Research
- Mental Health Treatment and Access
- COVID-19 Clinical Research Studies
- Computational Drug Discovery Methods
- SARS-CoV-2 and COVID-19 Research
- Cognitive Functions and Memory
- Meat and Animal Product Quality
- Technology Use by Older Adults
- Mass Spectrometry Techniques and Applications
- biodegradable polymer synthesis and properties
- Tuberculosis Research and Epidemiology
- Advanced Proteomics Techniques and Applications
- Mycobacterium research and diagnosis
- Fungal and yeast genetics research
- Behavioral Health and Interventions
- LGBTQ Health, Identity, and Policy
- Maternal Mental Health During Pregnancy and Postpartum
- Posttraumatic Stress Disorder Research
- COVID-19 and Mental Health
- Muscle Physiology and Disorders
- RNA and protein synthesis mechanisms
- Child Welfare and Adoption
The University of Melbourne
2022-2025
Melbourne Genomics Health Alliance
2023-2025
University of Wisconsin–Madison
2023-2024
United Hospital
2023
Monash University
2016-2022
University of South Florida
2019-2021
Australian Regenerative Medicine Institute
2021
In this study volatile and non-volatile flavour metabolites were systematically measured in prawn, scallop, squid, barramundi, salmon, snapper, tuna using headspace solid-phase microextraction gas chromatography-mass spectrometry for compounds, liquid taste metabolites, inductively coupled plasma mass elemental analysis. The data indicated that a core group of compounds commonly present across seafood species, contributing to fundamental flavour. Orthogonal partial least squares-discriminant...
While both human sphingosine kinases (SK1 and SK2) catalyze the generation of pleiotropic signaling lipid 1-phosphate, these enzymes appear to be functionally distinct. SK1 has well described roles in promoting cell survival, proliferation neoplastic transformation. The SK2, its contribution cancer, however, are much less clear. Some studies have suggested an anti-proliferative/pro-apoptotic function for while others indicate it a pro-survival role inhibition can anti-cancer effects. Our...
Drug-resistant strains of Mycobacterium tuberculosis are a major global health problem. Resistance to the front-line antibiotic isoniazid is often associated with mutations in katG-encoded bifunctional catalase-peroxidase. We hypothesise that perturbed KatG activity would generate collateral vulnerabilities isoniazid-resistant katG mutants, providing potential pathway targets combat resistance. Whole genome CRISPRi screens, transcriptomics, and metabolomics were used genome-wide map cellular...
Increased availability of Alzheimer's disease (AD) biomarker tests provides older adults with opportunities to seek out and learn results. We evaluated the feasibility virtually returning AD results.Trained study clinicians disclosed amyloid positron emission tomography (PET) results provided dementia risk-reduction counseling via televideo cognitively unimpaired participants already enrolled in research (n = 99; mean age ± SD: 72.0 4.8; 67% women; 95% White; 28% elevated).Our demonstrated...
Matrix-assisted laser desorption/ionization mass spectrometry imaging allows for the study of metabolic activity in tumor microenvironment brain cancers. The detectable metabolites within these tumors are contingent upon choice matrix, deposition technique, and polarity setting. In this study, we compared performance three different matrices, two techniques, use positive negative cancer types across species. Optimal combinations were confirmed by a comparative analysis lipid small-molecule...
Cancer cells often have dysregulated metabolism, which is largely characterized by the Warburg effect—an increase in glycolytic activity at expense of oxidative phosphorylation—and increased glutamine utilization. Modern metabolomics tools offer an efficient means to investigate metabolism cancer cells. Currently, a number protocols been described for harvesting adherent analysis, but techniques vary greatly and they lack specificity particular cell lines with diverse metabolic structural...
SARS-CoV-2 is the cause of COVID-19 pandemic which has claimed more than 6.5 million lives worldwide, devastating economy and overwhelming healthcare systems globally. The development new drug molecules vaccines played a critical role in managing pandemic; however, variants concern still pose significant threat as current cannot prevent all infections. This situation calls for collaboration biomedical scientists workers across world. Repurposing approved drugs an effective way fast-tracking...
Although various vaccines are now commercially available, they have not been able to stop the spread of COVID-19 infection completely. An excellent strategy get safe, effective, and affordable treatments quickly is repurpose drugs that already approved for other diseases. The process developing an accurate standardized drug repurposing dataset requires considerable resources expertise due numerous available could be potentially used address SARS-CoV-2 infection. To this bottleneck, we...
Abstract In Duchenne muscular dystrophy (DMD), corticosteroids significantly slow disease progression and have been used as a standard of care tool for more than 30 years. However, also impart side effects severe enough to preclude use in some patients. There remains an unmet need new therapeutics that target the flow-on pathogenic mechanisms DMD with favourable side-effect profile. We previously demonstrated short-term treatment dual-purpose anti-inflammatory, anti-oxidative dimethyl...
Proteomics and metabolomics reveal a shifted metabolism to support elevated ROS cytoskeletal protein changes in β-adrenergic stimulated macrophages.
SARS-CoV-2, is the cause of COVID-19 pandemic which has claimed more than six million lives worldwide, devastating economy and overwhelming healthcare systems globally. The development new drug molecules vaccines played a critical role in managing pandemic; however, variants concern still pose significant threat as current cannot prevent all infections. This situation calls for collaboration biomedical scientists workers across world. Repurposing approved drugs an effective way fast-tracking...
Most eukaryotic mRNAs accommodate alternative sites of poly(A) addition in the 3' untranslated region order to regulate mRNA function. Here, we present a systematic analysis end formation factors, which revealed 3'UTR lengthening response loss core machinery, whereas Sen1 helicase resulted shorter 3'UTRs. We show that anti-cancer drug cordycepin, deoxyadenosine, caused nucleotide accumulation and usage distal sites. Mycophenolic acid, reduces GTP levels impairs RNA polymerase II (RNAP II)...
The authors have no conflicts of interest associated with this manuscript.
ABSTRACT Most eukaryotic mRNAs accommodate alternative sites of poly(A) addition in the 3’ untranslated region order to regulate mRNA function. Here we present a systematic analysis end formation factors, which revealed 3’UTR lengthening response loss core machinery, whereas Sen1 helicase resulted shorter 3’UTRs. We show that anti-cancer drug cordycepin, deoxyadenosine, caused nucleotide accumulation and usage distal sites. Mycophenolic acid, reduces GTP levels impairs RNA polymerase II...
Although various vaccines are now commercially available, they have not been able to stop the spread of COVID-19 infection completely. An excellent strategy quickly get safe, effective, and affordable treatment is repurpose drugs that already approved for other diseases as adjuvants along with ongoing vaccine regime. The process developing an accurate standardized drug repurposing dataset requires a considerable level resources expertise due commercial availability extensive array could be...
Abstract Background Frequent and remote cognitive assessment may improve sensitivity to subtle decline associated with preclinical Alzheimer’s disease (AD). However, repeated testing can result in unintended inflation of scores, due practice effects. The objective this study is evaluate the extent sessions non‐identical stimuli on performance determine if design or amyloid PET status moderates impact practice. Method Participants were recruited from longitudinal aging cohorts complete medial...
Abstract Background Frequent and remote cognitive assessment may improve sensitivity to subtle decline associated with preclinical Alzheimer’s disease (AD). Our objective was evaluate the feasibility, reliability, construct validity of repeated memory in late middle‐aged older adults. Method Participants were recruited from longitudinal aging cohorts complete medial temporal lobe‐based paradigms (Object‐In‐Room Recall [ORR], Mnemonic Discrimination for Objects Scenes [MDT‐OS], Complex Scene...
Suicide rates continue to rise, and clinicians mental health staff play a critical role in keeping suicidal clients safe. Safety planning, including means safety, may help decrease suicide risk. Unfortunately, availability evaluation of safety planning training for these providers are scarce. The goal the present study was evaluate training, LINC LIFE Planning (L2L SP). L2L SP is 150-minute, face-to-face program that teaches engage collaborative efforts, facilitate diverse client coping...
Background: Suicide risk following youth psychiatric hospitalization is of significant concern. This study evaluated Linking Individuals Needing Care (LINC), a theory-driven, comprehensive care coordination approach for discharged from crisis services. Aims: To pilot LINC's potential effectiveness in increasing service utilization and decreasing suicide risk. Method: Participants were 460 patients who received LINC approximately 90 days discharge Service utilization, depressive symptoms,...