A5042943768- Respiratory viral infections research
- Proteoglycans and glycosaminoglycans research
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Luminescence and Fluorescent Materials
- Polymer Surface Interaction Studies
- Dendrimers and Hyperbranched Polymers
- SARS-CoV-2 and COVID-19 Research
- Porphyrin and Phthalocyanine Chemistry
- Echinoderm biology and ecology
- Marine Biology and Environmental Chemistry
- Heparin-Induced Thrombocytopenia and Thrombosis
- Antimicrobial Resistance in Staphylococcus
- Transplantation: Methods and Outcomes
- Hydrogels: synthesis, properties, applications
- Viral Infections and Immunology Research
- Blood Coagulation and Thrombosis Mechanisms
- Influenza Virus Research Studies
- Nanoplatforms for cancer theranostics
- Respiratory Support and Mechanisms
- Advanced Polymer Synthesis and Characterization
- Systemic Lupus Erythematosus Research
- Photodynamic Therapy Research Studies
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
Wrocław University of Science and Technology
2021-2022
AGH University of Krakow
2021-2022
Jagiellonian University
2011-2021
To date, six human coronaviruses have been known, all of which are associated with respiratory infections in humans. With the exception highly pathogenic SARS and MERS coronaviruses, (HCoV-NL63, HCoV-OC43, HCoV-229E, HCoV-HKU1) circulate worldwide typically cause common cold. In most cases, infection these viruses does not lead to severe disease, although acute infants, elderly, immunocompromised patients may progress disease requiring hospitalization. Importantly, no drugs against exist,...
Cationic derivatives of dextran (Dex) and hydroxypropylcellulose (HPC) were studied as potential alternatives protamine sulfate (PS) used in the reversal anticoagulant activity heparin. The modification was performed by attachment cationic groups to Dex main chain or grafting short side chains a polycation onto HPC. these polysaccharides found bind heparin with efficiency increasing growing degree modification. consequently ζ polymers do not have be high achieve effective binding. size...
The aim of the performed studies was to thoroughly examine internal structure self-assembled nanocarriers (i.e., polymeric micelles—PMs) by means a hydrophobic phthalocyanine probe in order identify crucial features that are required enhance photoactive stability and reactivity. PMs hydrophilic poly(ethylene glycol) poly(ε-caprolactone) (PCL) or poly(d,l-lactide) (PDLLA) were fabricated loaded with tetra tert-butyl zinc(II) (ZnPc-t-but4), multifunctional spectroscopic profound ability...
Human metapneumovirus (hMPV) is a widely distributed pathogen responsible for acute upper and lower respiratory infections of varying severity. Previously, we reported that N-sulfonated derivatives poly(allylamine hydrochloride) (NSPAHs) efficiently inhibit replication the influenza virus in vitro ex vivo. Here, show dose dependent inhibition hMPV infection by NSPAHs LLC-MK2 cells. The results showed strong antiviral properties NSPAHs. While activity comparable to those carrageenans, they...
Human herpesviruses are among the most prevalent pathogens and currently there no drugs available that could cure diseases induced by them. The widely utilized antiherpes drugs, acyclovir its derivatives, have serious limitations, such as low bioavailability severe side effects. current paper reports on synthesis characterization of cationic dextran derivatives (DEXxDSy) various molecular weights degrees substitution with ammonium groups, which were tested agents. DEXxDSy showed high...
Novel sulfonated derivatives of poly(allylamine hydrochloride) (NSPAHs) and N-sulfonated chitosan (NSCH) have been synthesized, their activity against influenza A B viruses has studied compared with that a series carrageenans, marine polysaccharides well-documented anti-influenza activity. NSPAHs were found to be nontoxic very soluble in water, contrast gel-forming thus generally poorly carrageenans.In vitroandex vivostudies using susceptible cells (Madin-Darby canine kidney epithelial fully...
This study was performed to evaluate the ability of N-(2-hydroxypropyl)-3-tri methylammonium chitosan chloride (HTCC), cationically modified chitosan, form biologically inactive complexes with unfractionated heparin and thereby blocking its anticoagulant activity. Experiments were carried out in rats vivo vitro using activated partial thromboplastin time (APTT) prothrombin (PT) tests for evaluation For first we have found that HTCC effectively neutralizes action rat blood as well vivo. The...
The layer-by-layer (LbL) method of polyelectrolyte multilayer (PEM) fabrication is extremely versatile. It allows using a pair any oppositely charged polyelectrolytes. Nevertheless, it may be difficult to ascribe particular physicochemical property the resulting PEM structural or chemical feature single component. A solution this problem based on application polycation and polyanion obtained by proper modification same parent polymer. Polyelectrolyte multilayers (PEMs) were prepared LbL...