A5076120779- Bone Metabolism and Diseases
- Gut microbiota and health
- Autophagy in Disease and Therapy
- Bone health and osteoporosis research
- RNA Interference and Gene Delivery
- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Education and Work Dynamics
- Bone health and treatments
- Urological Disorders and Treatments
- Diet and metabolism studies
- Lipid metabolism and disorders
- Ectopic Pregnancy Diagnosis and Management
- Immune Response and Inflammation
- Neuroinflammation and Neurodegeneration Mechanisms
- Higher Education and Teaching Methods
- Maternal and fetal healthcare
- Phytoestrogen effects and research
- Ovarian function and disorders
- Microbial Metabolites in Food Biotechnology
- Ginseng Biological Effects and Applications
- Extracellular vesicles in disease
- Urinary Tract Infections Management
- Microbial Natural Products and Biosynthesis
- Gestational Trophoblastic Disease Studies
Guangzhou University of Chinese Medicine
2016-2024
Guangdong Provincial Hospital of Traditional Chinese Medicine
2023
Abstract Osteoporosis is a serious bone disease affecting the aging population. Cistanche deserticola (CD), tonic and medicinal food widely used in China, has been proved to provide effective treatment for osteoporosis. polysaccharide (CDP), extracted from CD, possesses various pharmacological properties, but its role osteoclastic formation function as well osteoporosis remains unknown. The purpose of this study was extract purify CDP further explore potential mechanism action on Results...
Chronic inflammation plays a critical role in the pathogenesis of postmenopausal osteoporosis (PMO). Short-chain fatty acids (SCFAs) produced by gut microbiota (GM) have emerged as key regulators inflammatory response. Cistanche deserticola polysaccharide (CDP), derived from traditional Chinese medicine deserticola, possesses potent anti-inflammatory properties. However, precise mechanism which CDP modulates PMO via gut-bone axis remains elusive. In this study, we elucidated that could...
This study explored the possible connection between insulin resistance-targeting protein adipokine lipocalin-2 (LCN-2) and NF-κB signaling pathway in inflammatory microenvironment PCOS-IR model rats to determine pharmacological mechanism of modified Cangfu Daotan decoction (MCDD) intervention for PCOS-IR. We used a high-fat diet (42 days) combined with letrozole (1 mg/kg/day, 42 establish rat model. From third week after modeling, were given continuous administration MCDD (high dose 31.68...
Abstract Overactive bladder (OAB) is a common, long-term symptom complex with high prevalence in women worldwide. OAB has caused social burden, and effective treatments are urgently needed. However, the pathogenesis of yet to be elucidated. Model rats underwent outlet obstruction surgery. In 2nd, 3rd, 4th weeks after surgery, metabolic cages were used detect 12 h urine volume sham model groups. The urodynamic parameters leak point pressure (BPLL), maximum voiding (MVP), residual (RV),...
Abstract Glaucic acid isolated from the root of Lindera glauca , was investigated by biotransformation methods via endophytic fungi, resulting in production five new glausesquiterpenes A–E ( 1 – 5 ), along with a known analogue 6 . Their structures were elucidated based on spectroscopic and electronic circular dichroism (ECD) calculations. In bioassays, glausesquiterpene A ) showed good inhibitory activity NO LPS‐activated RAW 264.7 macrophages an IC 50 value 20.1 μM than positive control...
One of the main issues faced by nervous system diseases is that drugs are difficult to enter brain. The previous study suggested Cyclovirobuxine D (CVBD) encapsulated in Angiopep-conjugated Polysorbate 80-Coated Liposomes showed a better brain targeting intranasal administration. Therefore, this concentrated on protection and mechanism CVBD brain-targeted liposomes treating CIRI. Middle cerebral artery occlusion-reperfusion induced CIRI model rats explore protective effect liposome Moreover,...
In the context of Popular Entrepreneurship and Innovation, scientific systemic implementation innovation entrepreneurship education is focus higher reform at present. This paper analyzes important significances carrying out in traditional Chinese Medicine, introduces specific practices experi-ences designing educational concept constructing system about entrepre-neurship education, following objective laws modern development growth pattern medicine talents, order to provide reference for...
Abstract Background Overactive bladder (OAB) is a common, long-term symptom complex with high prevalence in women worldwide. The pathogenesis of OAB has not been elucidated. This study investigated the excitatory purinergic and cholinergic nerve conduction rat model induced by partial outlet obstruction(PBOO）. Methods Model rats underwent obstruction surgery. In 2nd, 3rd, 4th week after surgery, metabolic cages were used to detect 12-hours Urine volume sham groups. urodynamic parameters...
Abstract The lack of effective therapy mandates development treatment for cerebral ischemia-reperfusion injury (CIRI. previous study suggested that Cyclovirobuxine D (CVBD) encapsulated in Angiopep-conjugated Polysorbate 80-Coated Liposomes showed a better brain targeting by intranasal administration. Therefore, this focused on the protection and mechanism CVBD brain-targeted liposomes treating CIRI. In order to evaluate these, CIRI rat model was induced middle artery occlusion...