A5006141303- Animal Nutrition and Physiology
- Probiotics and Fermented Foods
- Salmonella and Campylobacter epidemiology
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- MicroRNA in disease regulation
- Viral gastroenteritis research and epidemiology
- Aquaculture disease management and microbiota
- Trace Elements in Health
- Vitamin C and Antioxidants Research
- Ginseng Biological Effects and Applications
- interferon and immune responses
- Machine Learning in Bioinformatics
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Genomics and Phylogenetic Studies
- Ferroptosis and cancer prognosis
- RNA and protein synthesis mechanisms
- Phytochemicals and Antioxidant Activities
- Humic Substances and Bio-Organic Studies
Shandong Agricultural University
2020-2025
Ministry of Agriculture and Rural Affairs
2022-2024
Qingdao Agricultural University
2021
Harbin Medical University
2020
Salmonella enterica serovar Enteritidis (S. Enteritidis) is a common zoonotic pathogen that not only causes gastroenteritis or death of livestock and poultry but also poses serious threat to human health, causing severe economic losses the industry society. Herein, RNA-sequencing (RNA-seq) was used analyze transcriptome variation chicken cecum at four different time points (1, 3, 7, 14 days) following S. infection. There were 529, 1477, 476, 432 differentially expressed genes (DEGs) in days...
Abstract Background Salmonella enterica serovar Enteritidis (SE) is one of the food-borne pathogenic bacteria, which affects poultry production and poses severe threat to human health. The correlation immune system metabolism in chicken after SE inoculation important but not clear. In current study, we identified expression energy related genes using quantitative PCR evaluate between against Jining Bairi chicken. Results ATP5G1, ATP5G3 ND2 were significantly up-regulated at 1 dpi (day post...
Several studies have already identified the prognostic markers in colorectal cancer (CRC) based on somatic copy number alteration (SCNA). However, very little information is available regarding their value as a marker. Gene dosage effect one important mechanism of and dosage-sensitive genes are more likely to behave like driver genes. In this work, we propose new pipeline identify CRC. The RNAseq data, CRC from TCGA were assayed screen out SCNAs. Wilcoxon rank-sum test was used...
By combining the experiments of reciprocal crosses chicken infected with Salmonella enterica serovar Enteritidis (S. Enteritidis), we focused on common response cecal microbiota to an inflammatory state in respect transcriptome and microbiome. The inoculation S. improved microbial diversity promoted evolution our infection model. Correlation analysis between bacteria inflammation-related genes showed that some intestinal microorganisms were "inflammophile" thrived inflamed environment....
To study the effects of fulvic acid (FuA) on broiler performance, slaughter blood biochemistry index, anti-oxidant function, immune and intestinal microflora, 360 Arbor Acres (AA) chickens with similar body weights were randomly divided into 5 groups 6 replicates in each group 12 replicate current study. Chickens control (C) fed basal diet, test (I, II, III, IV) diet supplemented 0.05༅, 0.1༅, 0.2༅ 0.3༅ mineral FuA, respectively. The indicators measured hatching day, day 21 35. From whole...
In order to enrich the knowledge of chicken transcriptomic response Salmonella enterica serovar Enteritidis infection, 2-day-old chicks were orally inoculated with this bacteria (1.0 × 108 cfu/mL), and then cecum tissues 3 days post-inoculation utilized for RNA sequencing (6 replicates each treatment group control group). After analysis, we found a variety inflammatory genes triggered at mRNA level upon infection. Notably, expression profiles miRNA isomiR heterogeneous. Certain isomiRs...
Salmonella enterica, serovar Enteritidis (SE) is a food-borne pathogen, which can cause great threat to human health through consumption of the contaminated poultry products. Chicken main host SE. The mRNA and microRNA (miRNA) expression profiles were analyzed on cecum Shouguang chicken via next-generation sequencing bioinformatics approaches. treated group was inoculated SE, control with phosphate buffer saline (PBS).
Salmonella enterica serovar Enteritidis (SE) incurs foodborne illnesses and poses a severe threat to poultry industry human health. However, the molecular mechanisms underlying chicken responding SE inoculation remain elusive. Here, we characterized transcriptome proteome of cecum 3 days post inoculation. Totally, there were 332 differentially expressed genes 563 protein identified. The upregulated enriched in immune-related processes. downregulated proteins mainly correlated with metabolic...
Abstract Salmonella enterica serovar Enteritidis ( S. Enteritidis) can colonize in the intestinal tract of chickens and transmit to humans. In order decrypt mechanism avian resistance Enteritidis, we utilized two China local chicken breeds generate reciprocal crosses (the Cross Reverse‐cross). The lines hybrids were orally inoculated with at 2‐day old sampled 3 days post‐inoculation. Along analysis direction multi‐omics, differential metabolites, functional pathways correlated microbes,...
Abstract Background: Salmonella enterica serovar Enteritidis ( S . Enteritidis) bacteria can colonize intestinal tract of chicken and transmit to humans, while the microbiota are resistant their colonization. Our knowledge interplay between host, pathogen is scarce, particularly in context different genetic background such as reciprocal cross. Results: Comprehensive analysis microbiome metabolome showed that 23.4% genera 11.6% metabolites Cross, 17.2% 25.1% Reverse-cross were altered P...
Salmonella enterica serovar Enteritidis (S. Enteritidis) is a foodborne pathogen, which can cause great threats to human health through the consumption of contaminated poultry products. This research combines TMT labeling, HPLC and mass-spectrometry-based phosphoproteomics on cecum F1 cross Guangxi Yao chicken Jining Bairi chicken. The treated group was inoculated with 0.3 mL inoculum S. Enteritidis, control phosphate-buffered saline (PBS). A total 338 differentially phosphorylated...