A5101827776- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Cardiac Arrhythmias and Treatments
- Hematological disorders and diagnostics
- Cardiovascular Effects of Exercise
- Cardiac Ischemia and Reperfusion
- Pharmacological Receptor Mechanisms and Effects
- Receptor Mechanisms and Signaling
- Sarcoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Lipoproteins and Cardiovascular Health
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Ion Channels and Receptors
- Neuropeptides and Animal Physiology
Jining Medical University
2019
Shanghai Institute of Materia Medica
2018
Shanghai Center for Brain Science and Brain-Inspired Technology
2018
Libin Cardiovascular Institute of Alberta
2015-2017
University of Calgary
2015-2017
Dezocine is becoming dominated in China market for relieving moderate to severe pain. It believed that Dezocine's clinical efficacy and little chance provoke adverse events during the therapeutic process are mainly attributed its partial agonist activity at μ opioid receptor. In present work, we comprehensively studied pharmacological characterization of identified analgesic effect was a result action both κ receptors. We firstly found displayed preferential binding receptor over δ Dezocine,...
The NH2-terminal region (residues 1–543) of the cardiac ryanodine receptor (RyR2) harbors a large number mutations associated with arrhythmias and cardiomyopathies. Functional studies have revealed that is involved in activation termination Ca2+ release. three-dimensional structure has recently been solved. It composed three domains (A, B, C). However, roles these individual release are largely unknown. To understand functional significance each domains, we systematically deleted assessed...
β-Blockers are a standard treatment for heart failure and cardiac arrhythmias. There ∼30 commonly used β-blockers, representing diverse class of drugs with different receptor affinities pleiotropic properties. We reported that among 14 β-blockers tested previously, only carvedilol effectively suppressed ryanodine (RyR2)-mediated spontaneous Ca2+ waves during store overload, also known as overload-induced release (SOICR). Given the critical role SOICR in arrhythmogenesis, it is importance to...
Reduced protein expression of the cardiac ryanodine receptor type 2 (RyR2) is thought to affect susceptibility stress-induced ventricular tachyarrhythmia (VT) and alternans, but direct evidence for role RyR2 in VT alternans lacking. Here, we used a mouse model (crrm1) that expresses reduced level determine impact on VT, hypertrophy, sudden death. Electrocardiographic analysis revealed after injection relatively high doses caffeine epinephrine (agents commonly stress test), wild-type (WT)...
This study aimed to investigate the cardioprotection of rosuvastatin pre-conditioning (R-Pre) in a rat model myocardial ischemia / reperfusion (I/R). Male SD rats were assigned into three groups: sham group, I/R group and R-Pre group. Rats received for 30 min 2 h. In intragastrical administration with at 5 mg/kg once daily 1 week. After 2-h reperfusion, cardiac function was detected by ultrasonography; blood collected biochemical analysis; heart TUNEL staining immunohistochemistry Bcl-2 Bax....