A5073769029- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Meningioma and schwannoma management
- CAR-T cell therapy research
- Cerebrospinal fluid and hydrocephalus
- Cancer Genomics and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Immunotherapy and Immune Responses
- Pituitary Gland Disorders and Treatments
- Immune Cell Function and Interaction
- Spinal Fractures and Fixation Techniques
- Chromatin Remodeling and Cancer
- Scoliosis diagnosis and treatment
- Graphene and Nanomaterials Applications
- Spine and Intervertebral Disc Pathology
- Cancer-related Molecular Pathways
- Ammonia Synthesis and Nitrogen Reduction
- Growth Hormone and Insulin-like Growth Factors
- Diabetic Foot Ulcer Assessment and Management
- Venous Thromboembolism Diagnosis and Management
- Spinal Dysraphism and Malformations
- Sleep and Wakefulness Research
- Cold Fusion and Nuclear Reactions
Taichung Veterans General Hospital
2015-2025
Weatherford College
2021
Chunghwa Telecom (Taiwan)
2011
Abstract This study utilized Next-Generation Sequencing (NGS) to explore genetic determinants of survival duration in Glioblastoma Multiforme (GBM) patients. We categorized 30 primary GBM patients into two groups based on their periods: extended (over years, N = 17) and abbreviated (under 13). For identifying pathogenic or likely variants, we leveraged the ClinVar database. The cohort, aged 23 66 (median: 53), included 17 Group A (survival >2 10 males, 7 females), 13 B <2 8 5 with a...
Background and Objectives: Recent advancements in spinal navigation methodologies, particularly augmented reality (AR) techniques, have significantly enhanced the precision of instrumentation procedures. This study aimed to evaluate efficacy AR-assisted surgery for thoracolumbar scoliosis. Materials Methods: retrospective observational included 10 patients with scoliosis who met specific inclusion criteria were recruited at a single medical center. Two neurosurgeons one neuroradiologist used...
Chitosan (Chi) is a natural polymer that has been demonstrated to have potential as promoter of neural regeneration. In this study, Chi was prepared with various amounts (25, 50, and 100 ppm) gold (Au) nanoparticles for use in vitro vivo assessments. Each as-prepared material first characterized by UV-visible spectroscopy (UV-Vis), Fourier-transform infrared (FTIR), atomic force microscopy (AFM), scanning electron (SEM), Dynamic Light Scattering (DLS). Through the experiments, combined 50...
Intracranial arteriovenous malformations (AVMs) are lesions containing complex vessels with a lack of buffering capillary architecture which might result in hemorrhagic cerebrovascular accidents (CVAs). Intraoperative navigation can improve resection rates and functional preservation patients eloquent areas, but current systems have limitations that distract the operator. Augmented Reality (AR) surgical technology reduce these distractions provide real-time information regarding vascular...
Intracranial collision tumors are rare diseases in which two distinct neoplasms found at the same location. We present an unusual case of intracranial tumor composed atypical meningioma (WHO grade II) and glioblastoma.The was a 56-year-old woman hospitalized due to generalized weakness dizziness. Imaging survey revealed right frontal lobe extra-axial mass with significant perilesional edema. The patient underwent one-stage craniotomy for removal. pathology brain clear cell glioblastoma. had...
Endovascular embolization is the treatment of choice for carotid-cavernous fistulas (CCFs), but failure to catheterize cavernous sinus may occur as a result vessel tortuosity, hypoplasia, or stenosis. In addition conventional transvenous transarterial routes, alternative approaches should be considered. The authors present case in which straightforward route CCF was accessed via transsphenoidal puncture neurosurgical hybrid operating suite. This 82-year-old man presented with severe chemosis...
Abstract Background It has previously been shown that bevacizumab, when added to chemotherapy, improved overall survival in several cancers. In glioblastoma multiforme (GBM), bevacizumab increased progression-free and it is widely used for tumor recurrence, though failed improve (OS) controlled trials. However, an effective biomarker predicting the prognosis of treatment yet be identified. This study, therefore, aimed retrospectively analyze polymorphisms p53 codon 72 clinical...
Background: Intraprocedural arterial perforation (IPAP) is a potentially dismal complication of neuroendovascular therapy with high mortality and morbidity rates. The management IPAP the techniques described has been well established, but rescue results from dual-trained endovascular neurosurgeon in neurosurgical hybrid operating room (OR) are rarely reported. Here, we report five cases successful OR compare them other series. Methods: Between December 2009 2013, 146 intracranial procedures...
Abstract Background Dendritic Cell Cytokine-induced killer cell (DC-CIK) coculture treatment in cancer immunotherapy has been shown to be effective. However, the cost of DC- CIK therapy is prohibitive for many patients, and lack standard manufacturing processes strategies are major limitations. Our study used tumor lysate as a tumor-associated antigen source DCs cells coculture. We developed an efficient method obtain autologous DCs- from peripheral blood. flow cytometry assess DC activation...
The number of femto-cell users will increase dramatically in the future, but unbalanced load distribution environment is unavoidable because would move around. User Equipments (UE) located overlapped coverage area two neighbor femto-cells can make one overloaded while other not. In this situation, an introduces network congestion to its serving UEs and blocks new connections. Instead considering only bandwidth usage femto-cells, we propose a method that also consider users' movements between...
Dopamine agonists such as bromocriptine and cabergoline have been found to be an effective treatment for hyperprolactinemia, not only inducing adenoma shrinkage but also lowering serum prolactin levels. Among known dopamine agonists, is the drug of choice due its enhanced tolerability compared with bromocriptine. This study aimed evaluate cabergoline's effectiveness, along transsphenoidal surgery, in hyperprolactinemia.We retrieved all patients a diagnosis prolactinoma who were treated our...
Asthma, which is caused by inflammation of the airways, affects sensitivity nerve endings. Narcolepsy a chronic sleep disorder that may be autoimmunity. Recent studies have reported positive association between narcolepsy and asthma. We aimed to examine asthma determine effects therapeutic corticosteroid or bronchodilator use.We conducted nationwide population-based, nested case-control study using Taiwan's National Health Insurance Research Database (NHIRD) 2000 2013. Subjects with...
Ventriculoperitoneal shunts are used as a common treatment for hydrocephalus to divert cerebrospinal fluid into the peritoneal cavity. However, shunt devices have high incidence of malfunction mainly caused by catheter obstruction or infection and associated with various complications, 10–30% which abdominal. These complications include: pseudocysts; pseudotumor mesentery; inguinal hernia; volvulus; ascites; peritonitis; migration through vagina, scrotum, umbilicus, intestinal tract;...
Augmented reality (AR) has emerged as a promising technology in various medical fields.1 2 In the context of brain arteriovenous malformation (bAVM) surgery, AR offers potential to enhance surgical visualization and improve procedural accuracy.3 4 5 6 This report aims explore application digital subtraction angiography (DSA) from an IV contrast injection (IV-DSA) AR-guided resection bAVMs neurosurgical hybrid operating room. The workflow IV-DSA-based surgery for consists four main...
The COVID-19 pandemic has become increasingly worse worldwide since it was discovered in China late December 2019. Easy contact transmission between people and a low to moderate mortality rate may cause failure medical health services if there is no proper personal protective equipment for personnel. During the pandemic, patients with acute ischemic stroke large-vessel occlusion who required immediate treatment through mechanical thrombectomy (MT) were still being sent emergency room....
Abstract Background Dendritic Cell Cytokine-induced killer cell (DC- CIK) coculture treatment in cancer immunotherapy has been shown to be effective. However, the cost of DC- CIK therapy is prohibitive for many patients, and lack standard manufacturing processes strategies are major limitations. Our study used tumor lysate as a tumor-associated antigen source DCs cells coculture. We developed an efficient method obtain autologous DCs- from peripheral blood. flow cytometry assess DC...
Abstract This study employed NGS to investigate genetic factors influencing extended (A: over two years) versus abbreviated (B: under survival in GBM. We analyzed 30 treatment-naïve GBM patients, categorizing them into groups: years (N = 17) and 13) survival. The ClinVar database aided confirming pathogenic or likely variants. cohort, aged 23 66 (median: 53), included 17 patients Group A (survival > 2 years, 10 males, 7 females), 13 B < 8 5 with a 60–40% male-to-female ratio....
Abstract TIMP metallopeptidase inhibitor 1 (TIMP-1) has been identified as a multifunctional molecule with divergent functions. It participates in wound healing and regeneration, cell morphology survival, tumor metastasis, angiogenesis, inflammatory responses. An imbalance of Matrix Metalloproteinase/TIMP regulation implicated several diseases. TIMP-1 could be considered an important regulator the process liver fibrosis bile duct degeneration. Thus, we aimed to determine role rat model...