A5088415817- Cervical Cancer and HPV Research
- Cancer Genomics and Diagnostics
- Cancer and Skin Lesions
- Genetic factors in colorectal cancer
- Lymphoma Diagnosis and Treatment
- Genital Health and Disease
- Galectins and Cancer Biology
- Epigenetics and DNA Methylation
- vaccines and immunoinformatics approaches
- Cancer-related gene regulation
- Glycosylation and Glycoproteins Research
- Peptidase Inhibition and Analysis
- Nonmelanoma Skin Cancer Studies
Heidelberg University
2015-2022
University Hospital Heidelberg
2019-2022
German Cancer Research Center
2015-2021
European Molecular Biology Organization
2019
Abstract The immune system can recognize and attack cancer cells, especially those with a high load of mutation-induced neoantigens. Such neoantigens are abundant in DNA mismatch repair (MMR)-deficient, microsatellite-unstable (MSI) cancers. MMR deficiency leads to insertion/deletion (indel) mutations at coding microsatellites (cMS) neoantigen-inducing translational frameshifts. Here, we develop tool quantify frameshift MSI colorectal endometrial cancer. Our results show that mutation...
BACKGROUND The human papillomavirus (HPV) E2 protein is a transcriptional repressor of the oncogenes E6/E7 and loss function considered key step in carcinogenesis. Integration HPV into host genome may disrupt gene. Furthermore, methylation CpG dinucleotides E2‐binding sites (E2BSs) upstream regulatory region interfere with repression E6 E7 by E2. authors hypothesized that status E2BS identifies subtypes type 16 (HPV16)‐associated oropharyngeal squamous cell cancers (OPSCC) association gene...
Abstract The immune system can recognize and attack cancer cells, especially those with a high load of mutation-induced neo antigens. Such antigens are particularly abundant in DNA mismatch repair (MMR)-deficient, microsatellite-unstable (MSI) cancers. MMR deficiency leads to insertion/deletion (indel) mutations at coding microsatellites (cMS) antigen-inducing translational frameshifts. abundance mutational renders MSI cancers sensitive checkpoint blockade. However, the neoantigen landscape...
Glycosylation is the most prevalent and varied form of post-translational protein modifications. Protein glycosylation regulates multiple cellular functions, including folding, cell adhesion, molecular trafficking clearance, receptor activation, signal transduction, endocytosis. In particular, membrane proteins are frequently highly glycosylated, which both linked to physiological processes high relevance in various disease mechanisms. The glycome increasingly considered be a therapeutic...
Background: The optimal management of vulvar high grade squamous intraepithelial lesions (vHSIL) is challenging. Surgery currently the standard treatment, but recurrences are observed in half patients. Medical treatment with imiquimod an effective alternative, two modalities have not been compared a randomised trial.Methods: We recruited female patients histologically confirmed vHSIL from 6 hospitals to non-inferiority trial. Patients were or surgery at ratio 1:1, stratified by unifocal...