A5014559160- SARS-CoV-2 and COVID-19 Research
- Gut microbiota and health
- Reproductive tract infections research
- Probiotics and Fermented Foods
- interferon and immune responses
- Bacterial biofilms and quorum sensing
- Vibrio bacteria research studies
- Urinary Tract Infections Management
- Influenza Virus Research Studies
- Pelvic floor disorders treatments
- Antimicrobial Peptides and Activities
- Infant Nutrition and Health
- Antimicrobial Resistance in Staphylococcus
- Microbial Metabolism and Applications
- CRISPR and Genetic Engineering
- Dermatological and COVID-19 studies
- Immunotherapy and Immune Responses
- Parvovirus B19 Infection Studies
- Vector-borne infectious diseases
- Intestinal Malrotation and Obstruction Disorders
- Muscle metabolism and nutrition
- Animal Virus Infections Studies
- Thermoregulation and physiological responses
- Microbial Community Ecology and Physiology
- Disaster Management and Resilience
APC Microbiome Institute
2023-2025
Teagasc - The Irish Agriculture and Food Development Authority
2021-2025
Ollscoil na Gaillimhe – University of Galway
2023-2024
University College Cork
2023-2024
National University of Ireland
2023-2024
National Maternity Hospital
2024
University College Dublin
2024
Science Foundation Ireland
2023
Rajiv Gandhi Centre for Biotechnology
2019-2023
Abstract A significant proportion of the infant gut microbiome is considered to be acquired from mother during and after birth. Thus begins a lifelong dynamic relationship with microbes that has an enduring impact on host health. Based cohort 135 mother-infant (F = 72, M 63) dyads (MicrobeMom: ISRCTN53023014), we investigated phenomenon microbial strain transfer, particular emphasis use combined metagenomic-culture-based approach determine frequency transfer involving members genus...
The composition of the infant microbiome can have a variety short- and long-term implications for health. It is unclear if maternal probiotic supplementation in pregnancy affect gut microbiome.This study aimed to investigate formulation Bifidobacterium breve 702258 from early until 3 months postpartum could transfer gut.This was double-blinded, placebo-controlled, randomized controlled trial B (minimum 1 × 109 colony-forming units) or placebo taken orally 16 weeks' gestation healthy pregnant...
Multidrug-resistant Staphylococcus aureus is a leading concern worldwide. Coagulase-Negative Staphylococci are claimed to be the reservoir and source of important resistant elements in S. aureus. However, origin evolutionary route genes still remaining unknown. Here, we performed detailed phylogenomic analysis 152 completely sequenced strains comparison with 7,529 non-Staphylococcus reference bacterial genomes. Our results reveal that has large open pan-genome where 97 (55%) its known...
The vaginal microbiome, a relatively simple, low diversity ecosystem crucial for female health, is often dominated by Lactobacillus spp. Detailed strain-level data, facilitated shotgun sequencing, can provide greater understanding of the mechanisms colonization and host-microbe interactions. We analysed 354 metagenomes from pregnant women in Ireland to investigate metagenomic community state types variation, focusing on cell surface interfaces. Our analysis revealed multiple subspecies, with...
Abstract Background SARS-CoV-2, the causative agent of COVID-19 pandemic is a RNA virus prone to mutations. Formation stable binding interface between Receptor Binding Domain (RBD) SARS-CoV-2 Spike (S) protein and Angiotensin-Converting Enzyme 2 (ACE2) host pivotal for viral entry. RBD has been shown mutate frequently during pandemic. Although, few mutations in exhibit enhanced transmission rates leading rise new variants concern, most show sustained ACE2 infectivity. Yet, how all these make...
Human gut microbiome composition and function is influenced by environmental lifestyle factors, including exercise fitness. We studied the functionality of faecal recreational (non-elite) runners (n = 62) with serial shotgun metagenomics, at 4 time points over a 7-week period. Gut was stable time. Grouping samples on basis their fitness level (fair, good, excellent, superior) or habitual training (low (4–6 h/week), medium (7–9 high (10–12 extreme (13 + hours/week)) revealed no significant...
Abstract Protein-protein interactions between virus and host are crucial for infection. SARS-CoV-2, the causative agent of COVID-19 pandemic is an RNA prone to mutations. Formation a stable binding interface Spike (S) protein R eceptor B inding D omain (RBD) SARS-CoV-2 A ngiotensin- C onverting E nzyme 2 (ACE2) actuates viral entry. Yet, how this evolves as acquires mutations during remains elusive. Here, using high fidelity bioinformatics pipeline, we analysed 31,403 genomes across globe,...
Abstract Background Human parvovirus B19V is a DNA virus, and member of the family Parvoviridae, that causes various clinical manifestations, from asymptomatic to persistent infection associated with different autoimmune diseases. The B19 evolves very high mutation rate closer those existing RNA viruses. Globally circulating currently classified into three genotypes, but their distribution not spatially temporally correlated. Except for few recent reports on entry human host its genetic...
Extreme flooding is one of the major risk factors for human health, and it can significantly influence microbial communities enhance mobility infectious disease agents within affected areas. The flood crisis in 2018 was severe natural calamities recorded southern state India (Kerala) that its economy ecological habitat. We utilized a combination shotgun metagenomics bioinformatics approaches to understand bacterial profile abundance pathogenic antibiotic-resistant bacteria extremely flooded...
Each year, 15 million infants are born preterm (<37 weeks gestation), representing the leading cause of mortality for children under age five. Whilst there is no single cause, factors such as maternal genetics, environmental interactions, and vaginal microbiome have been associated with an increased risk birth. Previous studies show that a microbiota dominated by Lactobacillus is, in contrast to communities containing mixture genera, full-term However, this binary principle does not fully...
Abstract Background The composition of the infant microbiome can have a variety short- and long-term implications for health. It is unclear if maternal probiotic supplementation in pregnancy impact gut microbiome. Objective aim our study was to investigate formulation Bifidobacterium breve 702258 from early until three months postpartum could transfer gut. Study design This double-blinded placebo controlled randomised-controlled trial B. (minimum 1×10 9 colony forming units) or taken orally...
Abstract Extreme flooding is one of the major risk factors for human health, and it can significantly influence microbial communities enhance mobility infectious disease agents within its affected areas. The flood crisis in 2018 was severe natural calamities recorded southern state India (Kerala) that economy ecological habitat. We utilized a combination shotgun metagenomics bioinformatics approaches understanding microbiome disruption dissemination pathogenic antibiotic-resistant bacteria...
While the immunomodulatory pathways initiated in immune cells contribute to therapeutic response, their activation cancer play a role progression. Also, many of aberrantly expressed immunomodulators on are considered as targets. Here, we introduce host defense peptide (HDP), known immuomodulator, agent target them. The cationic peptides (HDPs), an integral part innate system, possess membranolytic activity, which imparts antimicrobial and antitumor efficacy it. They act by activating cells....
Abstract Background The environmental microbiome has a direct influence on human health and disease. Previous reports suggest that urbanization anthropogenic activities can alter natural microbial flora potentially spread infectious disease-causing agents by emergence of pathogenic strains bacteria. nature microbes present in urban settings the flow genetic elements between clinically relevant bacteria, however, remains largely unknown. Results To unravel bacterial diversity resistome...
<title>Abstract</title> The vaginal microbiome, a relatively simple, low diversity ecosystem crucial for female health, is often dominated by Lactobacillus spp.. Studies of this community have relied on short read amplicon sequencing, limiting the taxonomic resolution to genus or species level. More detailed strain-level data, facilitated shotgun can provide greater understanding mechanisms colonization and host-microbe interactions. In study, we analysed 354 metagenomes from pregnant women...
Abstract Multi-drug resistant S. aureus is a leading concern worldwide. Coagulase-Negative Staphylococci (CoNS) are claimed to be the reservoir and source of important elements in . However, origin evolutionary route genes still remaining unknown. Here, we performed detailed phylogenomic analysis 152 completely sequenced strains comparison with 7,529 non- reference bacterial genomes. Our results reveal s that has large open pan-genome where 97 (55%) its known related belonging accessory...
Abstract Background: The anticancer activities of host defense peptides (HDPs) are mainly attributed to their cell penetrating activity. Accordingly, several approaches based on machine learning, calculating the membrane pore formation ability, have been proposed for anti-cancer peptide identification. Since membranolytic activity can lead nonspecific effects, like hemolysis, therapeutic application such molecules is limited. In this context, we considered immunomodulatory HDPs, which...