A5057755873- SARS-CoV-2 and COVID-19 Research
- interferon and immune responses
- Influenza Virus Research Studies
- CRISPR and Genetic Engineering
- Vibrio bacteria research studies
- Microbial Community Ecology and Physiology
- vaccines and immunoinformatics approaches
- Disaster Management and Resilience
- Viral gastroenteritis research and epidemiology
- Genomics and Phylogenetic Studies
- Fecal contamination and water quality
- COVID-19 Clinical Research Studies
- Bacteriophages and microbial interactions
- Antibiotic Resistance in Bacteria
- Animal Virus Infections Studies
- Gut microbiota and health
- Flood Risk Assessment and Management
- Bacterial biofilms and quorum sensing
- Protist diversity and phylogeny
UNSW Sydney
2024
Rajiv Gandhi Centre for Biotechnology
2019-2023
Abstract Background SARS-CoV-2, the causative agent of COVID-19 pandemic is a RNA virus prone to mutations. Formation stable binding interface between Receptor Binding Domain (RBD) SARS-CoV-2 Spike (S) protein and Angiotensin-Converting Enzyme 2 (ACE2) host pivotal for viral entry. RBD has been shown mutate frequently during pandemic. Although, few mutations in exhibit enhanced transmission rates leading rise new variants concern, most show sustained ACE2 infectivity. Yet, how all these make...
Extreme flooding is one of the major risk factors for human health, and it can significantly influence microbial communities enhance mobility infectious disease agents within affected areas. The flood crisis in 2018 was severe natural calamities recorded southern state India (Kerala) that its economy ecological habitat. We utilized a combination shotgun metagenomics bioinformatics approaches to understand bacterial profile abundance pathogenic antibiotic-resistant bacteria extremely flooded...
Abstract Protein-protein interactions between virus and host are crucial for infection. SARS-CoV-2, the causative agent of COVID-19 pandemic is an RNA prone to mutations. Formation a stable binding interface Spike (S) protein R eceptor B inding D omain (RBD) SARS-CoV-2 A ngiotensin- C onverting E nzyme 2 (ACE2) actuates viral entry. Yet, how this evolves as acquires mutations during remains elusive. Here, using high fidelity bioinformatics pipeline, we analysed 31,403 genomes across globe,...
Abstract Extreme flooding is one of the major risk factors for human health, and it can significantly influence microbial communities enhance mobility infectious disease agents within its affected areas. The flood crisis in 2018 was severe natural calamities recorded southern state India (Kerala) that economy ecological habitat. We utilized a combination shotgun metagenomics bioinformatics approaches understanding microbiome disruption dissemination pathogenic antibiotic-resistant bacteria...
Abstract Background The environmental microbiome has a direct influence on human health and disease. Previous reports suggest that urbanization anthropogenic activities can alter natural microbial flora potentially spread infectious disease-causing agents by emergence of pathogenic strains bacteria. nature microbes present in urban settings the flow genetic elements between clinically relevant bacteria, however, remains largely unknown. Results To unravel bacterial diversity resistome...
Most bacterial swimming is powered by the flagellar motor, a nanomachine that self-assembles from up to 45 proteins into membrane-spanning complex. The number and types of involved in motor vary widely. Predicting motility genomic data can facilitate large-scale studies where experimental validation may not be feasible. Using sequence structural homology, we conducted homology searches for 54 pathway genes across 11,365 genomes. We developed validated classifier predict whether specific...