A5022495322- Intraocular Surgery and Lenses
- Traumatic Ocular and Foreign Body Injuries
- Neuroscience and Neuropharmacology Research
- Retinal and Optic Conditions
- Drug-Induced Ocular Toxicity
- Facial Trauma and Fracture Management
- Genetics and Neurodevelopmental Disorders
- Epilepsy research and treatment
- Receptor Mechanisms and Signaling
- Herpesvirus Infections and Treatments
- Systemic Lupus Erythematosus Research
- Acne and Rosacea Treatments and Effects
- Sympathectomy and Hyperhidrosis Treatments
- Facial Nerve Paralysis Treatment and Research
- Ophthalmology and Visual Health Research
- Biomedical Research and Pathophysiology
- Restraint-Related Deaths
- Ion channel regulation and function
- Ocular Diseases and Behçet’s Syndrome
- Nasolacrimal Duct Obstruction Treatments
University of Miami
2024
Emory University
2017-2024
Baylor College of Medicine
2020-2021
N-methyl-D-aspartate receptors (NMDARs), ligand-gated ionotropic glutamate receptors, play key roles in normal brain development and various neurological disorders. Here we use standing variation data from the human population to assess which protein domains within NMDAR GluN1, GluN2A GluN2B subunits show strongest signal for being depleted of missense variants. We find that this includes GluN2 pre-M1 helix linker between agonist-binding domain (ABD) first transmembrane (M1). then evaluate...
Abstract N-methyl- d -aspartate receptors (NMDARs) are members of the glutamate receptor family and participate in excitatory postsynaptic transmission throughout central nervous system. Genetic variants GRIN genes encoding NMDAR subunits associated with a spectrum neurological disorders. The M3 transmembrane helices couple directly to agonist-binding domains form helical bundle crossing closed that occludes pore. functions as transduction element whose conformational change couples ligand...