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Eric J. Rellinger

ORCID: 0000-0003-2557-5719
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About
Contact & Profiles
A5106388574
Research Areas
  • Neuroblastoma Research and Treatments
  • Ubiquitin and proteasome pathways
  • Cancer, Hypoxia, and Metabolism
  • Signaling Pathways in Disease

University of Kentucky
 2024-2025

Markey Cancer Center
 2025

 GDP-mannose 4,6-dehydratase is a key driver of MYCN-amplified neuroblastoma core fucosylation and tumorigenesis
OPENALEX - Publications 
Beibei Zhu Michelle G. Pitts Michael D. Buoncristiani Lindsay Bryant Oscar Lopez‐Nunez and 12 more Juan P. Gurría Cameron J. Shedlock Roberto A. Ribas Shannon Keohane Jinpeng Liu Chi Wang Matthew S. Gentry Nathan R. Shelman Derek B. Allison B. Mark Evers Ramon C. Sun Eric J. Rellinger

MYCN-amplification is a genetic hallmark of ~40% high-risk neuroblastomas (NBs). Altered glycosylation common feature adult cancer progression, but little known about how signatures such as alter profiles. Herein, matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) revealed increased core fucosylated glycan abundance within neuroblast-rich regions human MYCN-amplified NB tumors. GDP-mannose 4,6-dehydratase (GMDS) responsible for the first-committed and...

10.1038/s41388-025-03297-0 article EN cc-by-nc-nd Oncogene 2025-02-16
 GDP-mannose 4,6-Dehydratase is a Key Driver of MYCN-amplified Neuroblastoma Core Fucosylation and Tumorigenesis
OPENALEX - Publications 
Eric J. Rellinger Beibei Zhu Michelle G. Pitts Michael D. Buoncristiani Lindsay Bryant and 12 more Oscar Lopez‐Nunez Juan P. Gurría Cameron J. Shedlock Roberto A. Ribas Shannon Keohane Jinpeng Liu Chi Wang Matthew S. Gentry Nathan Shelman Derek B. Allison B. Mark Evers Ramon C. Sun

<title>Abstract</title> <italic>MYCN-</italic>amplification is a genetic hallmark of ~ 40% high-risk neuroblastomas (NBs). Altered glycosylation common feature adult cancer progression, but little known about how signatures such as <italic>MYCN</italic>-amplification alter profiles. Herein, matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) revealed increased core fucosylated glycan abundance within human <italic>MYCN-</italic>amplified NB tumors. GDP-mannose...

10.21203/rs.3.rs-4720665/v1 preprint EN cc-by Research Square (Research Square) 2024-08-11
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