A5016431127- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- PI3K/AKT/mTOR signaling in cancer
- Bioactive Compounds and Antitumor Agents
- Urological Disorders and Treatments
- RNA modifications and cancer
- Cutaneous Melanoma Detection and Management
- Ovarian cancer diagnosis and treatment
- Bone and Dental Protein Studies
- Cancer Mechanisms and Therapy
- Synthesis and biological activity
- Lipoproteins and Cardiovascular Health
- Phytochemistry Medicinal Plant Applications
- Bladder and Urothelial Cancer Treatments
- Peroxisome Proliferator-Activated Receptors
- Cytokine Signaling Pathways and Interactions
- HER2/EGFR in Cancer Research
- interferon and immune responses
- Phytochemistry and Bioactivity Studies
- Drug Transport and Resistance Mechanisms
- Ear and Head Tumors
- Advanced Breast Cancer Therapies
- Cancer therapeutics and mechanisms
- Bee Products Chemical Analysis
Instituto Nacional do Câncer
2017-2024
The University of Sydney
2022
UNSW Sydney
2022
Cancer Institute (WIA)
2019
Universidade Federal do Espírito Santo
2012-2019
// Vitor Hugo de Almeida 1, 2 , Isabella dos Santos Guimarães Lucas R. Almendra 1 Araci M.R. Rondon Tatiana M. Tilli 3 Andréia C. Melo Cinthya Sternberg 2, 4 and Robson Q. Monteiro Instituto Bioquímica Médica Leopoldo De Meis, Universidade Federal do Rio Janeiro, RJ, Brazil Divisão Pesquisa Clínica e Desenvolvimento Tecnológico, Nacional Câncer, Centro Tecnológico em Saúde, Fundação Oswaldo Cruz, Present...
OBJECTIVE: To test the effectiveness of combining conventional antineoplastic drugs (cisplatin and etoposide) with metformin in treatment non-small cell lung cancer NCI-H460 line, order to develop new therapeutic options high efficacy low toxicity.METHODS: We used 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay calculated combination index for studied.RESULTS: found that use as monotherapy reduced metabolic viability line studied. Combining cisplatin or etoposide...
Murici (Byrsonima crassifolia (L.) Kunth and B. verbascifolia DC.) tapereba (Spondias mombin) are Amazonian fruits that contain bioactive compounds. Biochemical molecular characterization of these can reveal their potential use in preventing diseases, including cancer. The extracts were characterized regarding the presence profile carotenoids by high-performance liquid chromatography (HPLC), total phenolic content Folin–Ciocalteu assay, antioxidant activity value...
Aging | doi:10.18632/aging.203074. Taciane Barbosa Henriques, Diandra Zipinotti dos Santos, Isabella Santos Guimarães, Nayara Gusmão Tessarollo, Paulo Cilas Morais Lyra-Junior, Patricia Mesquita, Diana Pádua, Ana Luisa Amaral, Bruno Cavadas, Pereira, Ian Victor Silva, Raquel Maria da Silva Graça Almeida, Leticia Batista Azevedo Rangel
Geopropolis is produced by some stingless bee species, such as Melipona fasciculata Smith, a native species from Brazil. This study aims to investigate the antioxidant and anti-inflammatory activities cytotoxicity effects of geopropolis hydroethanolic extracts against lung (H460 A549) ovarian (A2780 ES2) cancer cell lines non-tumor (HUVEC) using chemical identification LC/MS/MS analysis in silico assays determine which compounds are associated with bioactivity. The activity inhibitory COX...
Osteopontin (OPN) is upregulated in several types of tumor and has been associated with chemoresistance. However, the contribution OPN splicing isoforms (OPN‑SIs) to chemoresistance requires further investigation. The present study aimed evaluate expression patterns each tested OPN‑SI cisplatin (CDDP)‑resistant ovarian carcinoma cell lines, focusing on role OPN‑c isoform (OPNc) drug resistance. ACRP cancer cells resistant CDDP, as well their parental line A2780, were used. Analyses...
Abstract Background Acquired treatment resistance is a significant problem in breast cancer management, and alterations lipid metabolism have been proposed to contribute the development of drug as well other aspects tumor progression. The present study aimed identify role cholesterol MCF-7 MDA-MB-231 cell response cisplatin (CDDP) acute setting model CDDP resistance. Methods (luminal A), (triple-negative) CDDP-resistant (MDACR) lines were grown presence or absence combination with...
Melanoma is the most lethal skin cancer, and its incidence has increased worldwide. About 10% of cases are classified as hereditary melanoma (HM). CDKN2A CDK4 major high-risk genes. Families also more prone to develop pancreatic different forms oncological surveillance recommended.Describe prevalence CDKN2A/CDK4 germline mutations in melanoma-prone patients their phenotypic histopathological features.A total 69 meeting clinical criteria for HM were included this cross-sectional descriptive...
The standard treatment for locally advanced cervical cancer (CC) is chemo-radiotherapy. Once the bladder receives part of radiation, a typical inflammatory condition that configures radiation-induced cystitis may develop. Chronic commonly characterized by new submucosal vascularization, which typically fragile and favors hematuria. current study aims to investigate if Hypoxia-Induced Factor (HIF-1α) its transcriptional target Vascular Endothelial Growth A (VEGF-A) could be primary pathway...
Abstract Background: Due to the acquisition of chemoresistant phenotype by epithelial ovarian cancer (EOC) cells and, consequently, disease relapse, identification novel therapeutic strategies is urgent. Herein, we targeted phosphodiesterase 7A (PDE7A) in EOC cells, based on data derived from RNA-sequencing assays comparing high-grade serous carcinoma (HGSOC) and fallopian tube samples. Methods: To understand role PDE inhibition, evaluated effects its inhibitor BRL50481 alone or combination...
In this study, eight naphthoquinone derivatives were synthesized in yields ranging from 52 to 96% using easy, fast, and low-cost methodologies. All screened for their vitro anti-proliferative activities against OVCA A2780 cancer cell lines. Amongst all analysed compounds, 3-5 presented the most prominent cytotoxic potential. Naphthoquinones 3 4, bearing sulfur-containing groups, identified as having high potential ROS production, particular superoxide anion. Furthermore, 4 compounds caused a...
Cancer is one of the leading causes death worldwide. Every year 8.2 million people die from disease. In this context, breast and ovarian cancer are most incidental among women. Elucidation cell growth pathways observation that these altered in human have encouraged search for specific inhibitors. The phosphatidylinositol-3cinase (PI3K)/Protein kinase b (AKT)/Mammalian Target Rapamycin (mTOR) an important pathway involved growth, tumorigenesis, invasion, resistance to therapies. This often...
Abstract Resistance to chemotherapeutic drugs corresponds main causes of treatment failure. Total osteopontin (OPN) has been described as a gene product involved on chemoresistance, besides activating several aspects tumor progression. OPN regulates the expression P-glycoprotein (P-gp) in prostate cancer (PCa) cells, promoting apoptosis evasion induced by chemotherapy using paclitaxel and estramustin. These data point potential therapeutic target approaches that could reduce resistance....
Abstract Breast cancer (BC) is the second most common kind of in world and among women. Its frequency rate becoming alarming, being this way a major challenge to global health. It worth mentioning that lack effective therapeutic options, particular for certain subtypes, such as triple-negative tumor, still present clinicians who often have resort highly unspecific cytotoxic therapies. Unfortunately, patients relapse after period remission eventually tumors becomes refractory frontline...
Abstract Epithelial ovarian cancer (EOC) remains the most lethal gynecologic malignancy. Indeed, EOC epidemiological scenario is partially due to its late diagnosis, when of tumor cells have acquired metastatic and chemoresistant phenotype. Despite initial satisfactory response platinum/taxanes-based therapy, chemoresistance emerges in an uncontrolled pace, specifically patient carries a high-grade serous adenocarcinoma (HGS-AC). Therefore, clinic urges for novel treatment possibilities,...
Breast cancer (BC) is the second most common kind of in world and among women. Its frequency rate becoming alarming, being this way a major challenge to global health. It worth mentioning that lack effective therapeutic options, particular for certain subtypes, such as triple-negative tumor, still present clinicians who often have resort highly unspecific cytotoxic therapies. Unfortunately, patients relapse after period remission eventually tumors becomes refractory frontline therapy. This...
Abstract Background: Acquired treatment resistance is a major problem in breast cancer management. Alterations lipid metabolism have been proposed to contribute tumor progression and the development of drug resistance. The present study aimed identify role cholesteryl ester (CE) MCF-7 MDA-MB-231 cell line response cisplatin (CDDP) acute setting. Methods: (luminal A), (triple-negative) CDDP-resistant (MDACR) lines were grown presence or absence CDDP combination with atorvastatin (ATV),...
Abstract Background: Acquired treatment resistance is a major problem in breast cancer management. Alterations lipid metabolism have been proposed to contribute tumor progression and the development of drug resistance. The present study aimed identify role cholesteryl ester (CE) MCF-7 MDA-MB-231 cell line response cisplatin (CDDP) acute setting. Methods: (luminal A), (triple-negative) CDDP-resistant (MDACR) lines were grown presence or absence CDDP combination with atorvastatin (ATV),...