A5101464556- CAR-T cell therapy research
- Advancements in Semiconductor Devices and Circuit Design
- Nanowire Synthesis and Applications
- Antimicrobial Peptides and Activities
- Meningioma and schwannoma management
- Sleep and Work-Related Fatigue
- Evolution and Genetic Dynamics
- Redox biology and oxidative stress
- Protein Structure and Dynamics
- Lung Cancer Treatments and Mutations
- CRISPR and Genetic Engineering
- Silk-based biomaterials and applications
- Cancer Immunotherapy and Biomarkers
- Selenium in Biological Systems
- Neurofibromatosis and Schwannoma Cases
- Workplace Health and Well-being
- Bacterial Genetics and Biotechnology
- Retinal Development and Disorders
- Enzyme Structure and Function
- RNA Interference and Gene Delivery
- Immune Response and Inflammation
- Employment and Welfare Studies
- Ferroptosis and cancer prognosis
- Glioma Diagnosis and Treatment
- Pediatric health and respiratory diseases
Central South University
2024
First Affiliated Hospital of Zhengzhou University
2020-2024
Xiangya Hospital Central South University
2024
State Key Laboratory of Biotherapy
2015-2020
Sichuan University
2015-2020
Glioblastoma (GBM) remains one of the most malignant primary tumors in adults, with a 5-year survival rate less than 10% because lacking effective treatment. Here, we aimed to explore whether B7-H3 could serve as novel therapeutic target for GBM chimeric antigen receptor (CAR) T cell therapy. In this study, CAR targeting was constructed and transduced into cells by lentivirus. Antitumor effects B7-H3-specific CAR-T were assessed lines both vitro vivo. Our results indicated that positively...
Purpose: Given that heterogeneous expression and variants of antigens on solid tumors are responsible for relapse after chimeric antigen receptor (CAR)-T cell therapy, we hypothesized combinatorial targeting two tumor-associated would lessen this problem enhance the antitumor activity T cells. Methods:The co-expression level CD70 B7-H3 was analyzed in multiple tumor tissue samples.Further, putative were identified The Cancer Genome Atlas Gene Expression Profiling Interactive Analysis...
Recently, B7-H3 was frequently reported to be overexpressed in various cancer types and has been suggested a promising target for immunotherapy. In the present study, we analyzed mRNA expression of The Cancer Genome Atlas (TCGA) database validated its across multiple types. We then generated novel B7-H3-targeted chimeric antigen receptor (CAR) tested antitumor activity both
Abstract Objective We conducted a first‐in‐human study to evaluate the bioactivity and safety of B7‐H3‐targeted chimeric antigen receptor (CAR) autologous T cells for treating recurrent anaplastic meningioma. Methods Tumor tissues from patient with meningioma were evaluated B7‐H3 expression. CAR‐T delivered into intracranial tumor resection cavity using an Ommaya device at maximum dose 1.5 × 10 7 cells. Magnetic resonance imaging (MRI) screening multiple serum indexes regularly monitored....
BRAF-V600E (1799T > A) is one of the most frequently reported driver mutations in multiple types cancers, and patients with such could benefit from selectively inactivating mutant allele. Near this mutation site, there are two TTTN NGG protospacer-adjacent motifs (PAMs) for Cpf1 Cas9 CRISPR nucleases, respectively. The 1799T A substitution also leads to occurrence a novel NGNG PAM EQR variant Cas9. We examined editing efficacy selectivity Cpf1, Cas9, site. Only demonstrated robust activity...
// Mei Tang 1, * , Heng Wei 2, Lu Han Jiaojiao Deng 3 Yuelong Wang Meijia Yang 1 Yani Gang Guo Liangxue Zhou Aiping Tong The State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center Biotherapy, West China Hospital, Medical School, Sichuan University, Chengdu 610041, 2 College Life Science, 610064, Department Neurosurgery, These authors have contributed equally to the work Correspondence to: Tong, email: aipingtong@scu.edu.cn Zhou, liangxue_zhou@126.com Keywords:...
In plants and microorganisms, aspartate kinase (AK) catalyzes an initial commitment step of the family amino acid biosynthesis. Owing to various structural organizations, AKs from different species show tremendous diversity complex allosteric controls. We report crystal structure AK Pseudomonas aeruginosa (PaAK), a typical α2β2 hetero-tetrameric enzyme, in with inhibitory effectors. Distinctive features PaAK are revealed by biochemical analyses. Essentially, open conformation Lys-/Thr-bound...
Abstract Background Shift work has become popular along with adverse effects such as disrupted biological rhythms, metabolic changes, sleep disorders and myocardial infarction. Studies have shown a link between infarction shift work, but evidence is still lacking. Aims We aim to explore the association present past risk of in large population European workers. Methods analysed data from UK Biobank >500 000 participants an average 12-year follow-up duration. Cox proportional hazard...