A5043617629- Cystic Fibrosis Research Advances
- Asthma and respiratory diseases
- Gastroesophageal reflux and treatments
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Helicobacter pylori-related gastroenterology studies
- Inhalation and Respiratory Drug Delivery
- Esophageal and GI Pathology
- Respiratory Support and Mechanisms
- Pediatric health and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Genomics and Rare Diseases
- Infective Endocarditis Diagnosis and Management
- Head and Neck Surgical Oncology
- Air Quality Monitoring and Forecasting
- Head and Neck Anomalies
- Neuroendocrine Tumor Research Advances
- Respiratory viral infections research
- Eosinophilic Esophagitis
- Genomic variations and chromosomal abnormalities
- Antimicrobial Peptides and Activities
- Coronary Artery Anomalies
- Sinusitis and nasal conditions
- Voice and Speech Disorders
University of Bari Aldo Moro
1994-2023
Institute for Biomedicine
2004
Hospital for Sick Children
1987
Multichannel intraluminal impedance (MII) is a pH-independent method of assessing gastroesophageal reflux.To evaluate the diagnostic accuracy MII-pH as compared with conventional pH monitoring in detecting reflux events (REs) and symptom association different age groups.: A prospective direct comparison 2 techniques on 291 consecutive patients referred for suspected disease. Sensitivity versus were measured.MII-pH detected 13631 REs, 6260 (46%) which nonacid. The prevalence weakly acid...
There are no recent data on primary ciliary dyskinesia (PCD) distribution, diagnosis and treatment in Italy.A descriptive study based a survey questionnaire. It consisted of three sections (patients, diagnosis, treatment), sent to all the Italian PCD Centers.Questionnaires obtained from 20/22 centers 12/20 regions showed that total number patients treated at participating was 416. Out centers, 55% follow <20 patients, two have >40 75% both pediatric adults. Age between 4 8 years 45% <3...
A study was designed to determine the sensitivity and specificity of a cold air bronchial provocation test. total 18 children with asthma (mean age 12 years) normal 14 were studied. The challenge consisted 4 min period isocapnic hyperventilation subfreezing temperature -15 degrees C). In-Induced response in forced expiratory volume 1 sec (FEV1) expressed as percentage predicted values obtained at 4, 6, 8 post-challenge. average 27% decrease FEV1 asthmatics, which significantly different from...
Radiotherapy of the head region in children is known to cause long-term sequelae, such as facial, dental, and ocular abnormalities. We investigated whether a decreased nasal mucociliary function occurs after radiotherapy children.A saccharin/charcoal test was performed 20 treated with controls, age-matched gender-matched.We found clearance (lower percentage responses (p = 0083) longer transport times =.0001) patients compared controls. The dosage influenced response =.0046).Irradiation may...
Exhaled nitric oxide (eNO) levels have been shown to correlate with atopy and airway hyperresponsiveness but not standard spirometry. The aim of our study was evaluate the correlation between eNo functional residual capacity (FRC), volume (RV), RV total lung (TLC) ratio, pulmonary resistances in asthmatic children ages 6–13 years. Forty‐nine patients (35 males) were enrolled study. Nineteen them receiving inhaled corticosteroids. eNO measured by chemiluminescence's analyzer function...
Currently, more than 1,000 mutations have been identified in the cystic fibrosis transmembrane regulator (CFTR) gene. While some are common worldwide, majority restricted certain ethnic groups. We found that Southern Italy, 852del22 mutation is well represented with a frequency of 3.5%. screened, by reverse dot blot, denaturing gradient gel electrophoresis (DGGE), and gene sequencing, entire coding regions CFTR 371 consecutive (CF) patients from Italy 17 carrying rare genotypes, among which...
<b>Background:</b> Expiratory Flow Accelerator (EFA) is a known technique which removes secretions noninvasively by accelerating expiratory flow. EFA permits to avoid the use of traditional aspiration systems, thereby reducing risk discomfort and infections in adult pediatric patients with genetic diseases such as neuromuscular disorders cystic fibrosis. To our knowledge, no studies have been addressed on Primary Ciliary Dyskinesia (PCD). <b>Aim:</b> We aimed evaluated clinical instrumental...
Eighteen asthmatic children were challenged with ultrasonically nebulized cold distilled water (UNCDW). Blood gas composition was monitored transcutaneously (tcpO(2) and tcpCO(2)) during after the challenge. Assuming as basal response to this UNCDW test, nine (Group A) then chosen at random inhale cromoglycate by aerosol delivery for 8 days. Nine B), acting a control, inhaled saline At end of therapy, each child repeated test. Statistical analysis t-test paired data used compare results both...