Objective: Type 2 diabetes mellitus (T2DM) is a well-defined risk factor of periodontitis and it can affect expression human beta-defensins (hBDs) cathelicidin (LL-37) as well. The aim the present study was to evaluate impact T2DM on salivary concentrations these antimicrobial peptides.Material methods: Unstimulated saliva samples, together with full-mouth periodontal recordings were collected from 92 individuals (63 21 smokers) 86 periodontally healthy controls (58 smokers). Salivary hBD-1,...

Type 1 diabetes mellitus (T1DM) is an autoimmune disease which characterized by the destruction of insulin producing pancreatic β-cells. Current evidence supports contribution T-cells, macrophages, B-cells, and dendritic cells to pathogenesis T1DM as well. T1DM-associated risk factors, including defects in host immune response, socioeconomic conditions environmental factors create dysbiotic environment oral cavity, support growth pathogenic microbial biofilms. Changes composition, together...

The aim was to profile serum and salivary levels of active-matrix metalloproteinase (aMMP)-8, tissue inhibitor MMP (TIMP)-1, aMMP-8/TIMP-1 ratio, total (tMMP)-9, tMMP-9/TIMP-1 myeloperoxidase (MPO), human neutrophil elastase (HNE) in periodontitis rheumatoid arthritis (RA).

Intrinsic apoptosis, which is regulated by Bcl-2 family proteins, has an important role in chronic inflammatory diseases. The aim of the study was to identify tissue levels and ratios anti- pro-apoptotic proteins peri-implant diseases.Twenty-three individuals with mucositis, 25 peri-implantitis, 24 controls were included. following clinical parameters recorded: keratinized mucosa width, modified bleeding index, probing depth, plaque gingival thickness. Marginal alveolar bone assessments...

Monocyte chemoattractant protein-1 (MCP-1), macrophage migration inhibitory factor (MIF), and fractalkine are chemokines that expressed by a variety of cell types to regulate inflammatory response. The aim the study was examine effects periodontitis rheumatoid arthritis (RA) on their serum salivary concentrations.Adults with either (P, n = 21), or (RA, 23), both diseases (RA+P, 23) were included in study. Systemically periodontally healthy individuals (n 22) served as controls. Saliva...

Abstract Background This cross‐sectional study aimed to evaluate salivary concentrations of macrophage activation‐related chemokines and mitogen‐activated kinase (MAPKK)‐degrading proteolytic activity in children adolescents with without type 1 diabetes mellitus (T1DM). Methods A total 122 (65 T1DM patients, 50.8% female, mean age:10.9 years; 57 systemically healthy controls, 36.8% age: 9.5 years) were included the study. Salivary interferon gamma inducible protein‐10 (IP‐10), monocyte...

Elevated levels of matrix metalloproteinase-7 (MMP7) have been observed in serum samples subjects with type 2 diabetes mellitus (T2DM) and gingival tissues periodontitis. The aim the present study was to collect vivo silico evidence on role MMP7 interplay between T2DM generalized periodontitis (GP).The extent expression localization were immunohistochemically analyzed patients GP (T2DM/GP, n = 11), systemically healthy (n 7), periodontally controls 11). An network model built determine...

A deeper understanding of periodontitis pathophysiology is central to future development novel biomarkers and therapeutics. The following reported here: 1) an in silico network model interactions among cell adhesion molecules a network-focused microarray analysis the corresponding genes periodontitis; 2) secretions gingival tissue samples from patients with healthy controls; 3) effect human neutrophilic peptide-1 (HNP-1) on epithelial molecules.The identified 85 nodes relation molecules....

BACKGROUND: In this study, we aimed to determine whether neutrophil / lymphocyte ratio (NLR), obtained by dividing the number of neutrophils lymphocytes, and uric acid (UA) levels in multiple sclerosis (MS) patients vary compared with healthy controls establish correlations among these changes themselves as well between such MS subtypes, immunomodulatory drug use, duration disease prognosis.METHODS: 150 who presented our hospital were diagnosed volunteers retrospectively included study.EDSS...

2019 yılı sonunda COVID-19 olarak tanımlanan, , atipik ve hızlı yayılabilen bir pnömoni türü tanımlanmıştır. Bu hastalık çok kısa süre sonra Dünya Sağlık Örgütü tarafından pandemi ilan edilmiştir. Dental işlemler sonucu oluşan damlacık aerosoller ile kontamine olan hekim, hasta çalışanlar dental klinik ortamını hızla enfekte ederek hastalığın yayılmasına sebep olabilirler. salgın ortamında diş hekimleri yardımcılarına da salgının yayılmasının önüne geçilmesi aşamasında önemli görevler...

The objectives of this retrospective study are to measure the amount alveolar crest cortication and around mandibular canal, evaluate bone density values crest, possible implant placement area for edentulous sites.Six hundred forty-two cone-beam computed tomography scans from 642 subjects were evaluated in four centers. Cortical thicknesses canal cortical borders (buccal, lingual, apical, coronal) each posterior teeth region measured. Bone recorded. correlations between numeric variables...

The aim of this retrospective study was to investigate anatomical structure mandibular canal and the factors those increase possibility inferior alveolar nerve damage in third molar region Turkish population. Overall 320 participants with 436 molars were included from four different centers. Following variables measured: type depth impaction, position relation molars, morphology canal, cortication status possible contact between thickness density superior, buccal, lingual wall, bucco-lingual...

summary The aim of this study was to evaluate the clinical performance a new generation restorative resin, Targis (Vivadent), in class II inlay restorations. Forty inlays were placed (18 premolars, 22 molars) 26 patients (mean age=25·5). All test teeth vital. restorations occlusion and adhesively using Variolink high viscosity (Vivadent) combination with Syntac adhesive system under rubber‐dam by same operator. evaluated at baseline after 6 months 1 year, according modified United States...

Summary. Immune abnormalities have been reported in patients with haemophilia. Although infections HIV and hepatitis viruses contribute to these abnormalities, chronic exposure extraneous proteins clotting factor concentrates (CFC) may also play a role. A number of studies suggest that the degree immunological correlates amount intermediate purity CFC administered over time. The purpose this study was investigate whether there were cellular humoral haemophilics receiving intensive...

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Objectives: Thermal trauma during implant surgery limits the proper healing process. The aim of study was to investigate effect different irrigation temperatures on osseointegration dental implants. Materials and Methods: Eight adult male New Zealand white rabbits were used in this study. Total 32 implants inserted each tibia rabbit’s rear legs. Rabbits randomly divided according procedures applied (37°C, 24°C, 10°C, 1°C). Resonance frequency analysis (RFA) performed following surgery, 1th...

Objective: Polyhexanide (PHMB; polyhexamethylene biguanide) is a well-known antiseptic agent; however, no data exist for its applicationon denture base and lining materials. In the present in vitro study, aim was to compare viable bacterial or fungal cell numbers theiradhesion on different types of materials diverse concentrations PHMB.Methods: Light-activated urethane dimethacrylate (UDMA), heat-polymerized polymethyl methacrylate (PMMA), heat-polymerizedpolydimethylsiloxane,...