A5045680139- Cancer Immunotherapy and Biomarkers
- Reproductive System and Pregnancy
- Cancer Cells and Metastasis
- Endometrial and Cervical Cancer Treatments
- Immune cells in cancer
- Immunotherapy and Immune Responses
- COVID-19 Impact on Reproduction
- Breast Cancer Treatment Studies
- Pregnancy and preeclampsia studies
- Immune Cell Function and Interaction
- Cervical Cancer and HPV Research
- Estrogen and related hormone effects
- Cytokine Signaling Pathways and Interactions
- Pituitary Gland Disorders and Treatments
- Cancer Mechanisms and Therapy
- Histone Deacetylase Inhibitors Research
- Sleep and related disorders
- Advanced Breast Cancer Therapies
- Birth, Development, and Health
- Breast Implant and Reconstruction
- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Multiple and Secondary Primary Cancers
- Adrenal Hormones and Disorders
- Minimally Invasive Surgical Techniques
University Hospital Augsburg
2021-2024
University of Augsburg
2020-2024
Klinik für Frauenheilkunde
2022-2024
Ludwig-Maximilians-Universität München
2023
Für die Sicherstellung einer fundierten frauenheilkundlichen Behandlung ist Weiterbildung von Ärztinnen und Ärzten in der Gynäkologie Geburtshilfe elementarer Bedeutung. Die "Weitblick"-Umfrage hatte zum Ziel, Weiterbildungsrealität Bayern online anhand eines anonymisierten Fragebogens zu erfassen.
Abstract Background Hypoxia is an important risk factor and indicator for the declining health of inpatients. Predicting future hypoxic events using machine learning a prospective area study to facilitate time-critical interventions counter patient deterioration. Objective This systematic review aims summarize compare previous efforts predict in hospital setting with respect their methodology, predictive performance, assessed population. Methods A literature search was performed Web Science,...
The development of a seroma after breast cancer surgery is common postoperative complication seen simple mastectomy and axillary surgery. We could recently demonstrate that patients undergoing with subsequent formation developed T-helper cell increase within the aspirated fluid measured by flow cytometry. same study revealed Th2 and/or Th17 immune response in peripheral blood patient. Based on these results population, we now analyzed Th2/Th17 associated cytokine content as well best known...
The role of progesterone receptor A (PRA) for the survival outcome cervical cancer patients is ambiguous. In mouse models, it has been shown that PRA plays a rather protective in development. aim this study was to assess its expression by immunohistochemistry 250 tissue samples and correlate results with clinicopathological parameters including patient survival. positively correlated International Federation Gynecology Obstetrics (FIGO) classification scores. significantly overexpressed...
Abstract At the beginning of coronavirus disease 2019 (COVID-19) pandemic, uncertainties about virus and its dangers during pregnancy caused great uncertainty fear, especially among pregnant women. New data suggest an increased risk obstetric complications, including maternal preterm labor, intrauterine growth restriction, hypertensive disorders, stillbirths, gestational diabetes risk, neonatal developmental disorders. In addition, preeclampsia (PE)-like syndromes were also induced by severe...
The collective of the SerMa pilot study included 100 cases primary breast cancer or Carcinoma in situ who had undergone a mastectomy procedure with without reconstruction using an implant expander at Augsburg University Hospital between 12/2019 and 12/2022. aimed to investigate possible causes seroma formation; reported here are clinicopathological correlations formation tumor biology surgical procedures. Seroma occurred significantly more often patients older age (median patient was 73...
There exists a variety of studies about tumor-infiltrating lymphocytes (TILs) in cervical cancer, but their prognostic value correlation to the histopathological subtype was never investigated. Therefore, aim this study quantify TILs panel 250 sporadic cancers and investigate with cancer patient survival. TIL levels were significantly increased subgroup squamous cell carcinomas comparison adenocarcinomas. In carcinomas, infiltration shows negative age, FIGO stage histone protein modification...
There exists a variety of studies about tumor-infiltrating immune cells (TIICs) in cervical cancer, but their prognostic value correlation with the histopathological subtype has never been investigated. Therefore, aim this study was to quantify TIICs panel 238 sporadic cancers and investigate cancer patient survival. levels were significantly increased subgroup CSCC (191 samples) comparison CAC (47 samples). In CSCC, TIICs' infiltration showed negative age, FIGO stage histone protein...
Abstract Background The primary objective of the SerMa pilot study was to identify possible immunological or inflammatory factors related seroma formation after mastectomy in cases with breast cancer. Preliminary data suggest a distinct association between age and formation. work presented here investigates therefore link differences microenvironment represented by tumor-associated macrophages. latter have been characterized expression CD68 CD163 receptors, that are markers cells from...
In light of the global increase in breast cancer cases and crucial importance density fibroglandular tissue (FGT) assessing risk predicting course disease, accurate measurement FGT emerges as a significant challenge diagnostic imaging. The current study focuses on automatic segmentation glandular MRI scans using deep learning model. aim is to establish solid foundation for development methods precise quantification tissue. For this purpose, publicly available ‘Duke Breast Cancer MRI’ dataset...
Zielsetzung: Nach systematischer inguinofemoraler Lymphonodektomie entwickeln ca. 80% der Patientinnen postoperative Leistenkomplikationen wie Lymphozelen, Wundheilungsstörungen und Infektionen, die Clavien-Dindo Grad III a oder höher erreichen. Das Ziel dieser Studie ist es, Rate Komplikationen durch Platzierung einer inguino-peritonealen Drainage zu reduzieren.
Zielsetzung: Das Mammakarzinom ist die häufigste Krebserkrankung und krebsbedingte Todesursache bei Frauen. In Vorpublikationen zeigten wir, dass eine höhere Infiltration CD68 (allgemeiner Makrophagenmarker)-positiver Makrophagen im Fettgewebe ein unabhängiger prognostischer Faktor für das Gesamtüberleben von Brustkrebspatientinnen ist. Ziele dieser retrospektiven Studie waren Bestätigung Ergebnisse an einem weiteren Mammakarzinom-Kollektiv unter Anwendung der Tissue-Micro-Array (TMA) Technik.
Einleitung: Exulzerierende Mammakarzinome bilden eine Subgruppe lokal fortgeschrittener Karzinome. Der Stellenwert der Tumormarker Carcinoembryonales Antigen (CEA) und Cancer 15-3 (CA 15-3) bei exulzerierenden Mammakarzinomen ist nicht abschließend geklärt.
Zielsetzung: Die Pathophysiologie der Serombildung als häufige postoperative Komplikation nach Mastektomie bei Brustkrebs ist bisher nur unzureichend verstanden. Hier setzt die SerMa (Serom-Untersuchung operativem Mammaeingriff) Pilot-Studie an, um treibende immunologische und klinische Faktoren für eine Seromentstehung zu untersuchen. Es werden jedoch auch mögliche perioperative Einflussfaktoren diskutiert. wird ein möglicher Zusammenhang zwischen intraoperativem Blutdruck mithilfe einer...
Vulvar cancer is the fourth most common malignancy of female genital tract after endometrial, ovarian, and cervical carcinoma affects mainly elderly women. In 2020 there were registered more than 17,000 deaths worldwide related to vulvar carcinoma. Data about target-based therapies predictive biomarkers for vulva carcinomas are rare so far. The metastasis-associated gene MTA1 a transcriptional repressor with potential effect on cancer. Expression was found be significantly enhanced in...
In this study we evaluate sleep patterns of patients treated for non-secreting intra- and parasellar tumors age- sex-matched healthy controls.We conducted a self-report cross-sectional case-control with 104 1800 controls in an 1:8 matching. All subjects answered the Munich ChronoType Questionnaire, whereas were provided Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, Short-Form 36 Health survey, Beck Depression Inventory State-Trait Anxiety additionally.Patients go to bed earlier,...
Abstract Purpose The development of a seroma after breast cancer surgery is common postoperative complication seen simple mastectomy and axillary surgery. We could recently demonstrate that patients undergoing with subsequent formation developed T helper cell increase within the aspirated fluid measured by flow cytometry. same study revealed Th2 and/or Th17 immune response in peripheral blood patient. Based on these results population, we now analyzed Th2/Th17 associated cytokine content as...
Einleitung Die Prognose von Patientinnen mit Zervixkarzinom wird Steroidhormonen beeinflusst. Expression Progesteron Rezeptor A im Zellkern (PRA_n) bei Zervixkarzinomen beeinflusst das Überleben Adenokarzinomen negativ [1]. Im Vergleich dazu ist die Progesteronrezeptor B Stroma (PRB_s) ein protektiver Faktor [2]. Es gibt Hinweise in Mausmodellen, dass der Brust für Entwicklung Mammakarzinomen [3]. Ziel dieser Studie ist, den Einfluss des PRA_s zu untersuchen.