A5055684849- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Chemokine receptors and signaling
- Reproductive Physiology in Livestock
- Congenital heart defects research
- Endometriosis Research and Treatment
- Signaling Pathways in Disease
- Neonatal Respiratory Health Research
- Cancer-related molecular mechanisms research
- Infant Nutrition and Health
- Cardiac Fibrosis and Remodeling
- Lymphatic System and Diseases
- Angiogenesis and VEGF in Cancer
- Pregnancy and Medication Impact
- Ruminant Nutrition and Digestive Physiology
- Gynecological conditions and treatments
- Physical Activity and Health
- Animal health and immunology
- Single-cell and spatial transcriptomics
- Axon Guidance and Neuronal Signaling
- Mesenchymal stem cell research
- Cancer, Stress, Anesthesia, and Immune Response
- Birth, Development, and Health
- Endometrial and Cervical Cancer Treatments
- Cytokine Signaling Pathways and Interactions
University of North Carolina at Chapel Hill
2018-2025
New Mexico State University
2012-2021
Iowa State University
2015
University of New England
2014
New South Wales Department of Primary Industries
2014
North Dakota State University
2012
BACKGROUND: Ischemic heart disease is a prevalent cause of death and disability worldwide. Recent studies reported rapid expansion the cardiac lymphatic network upon ischemic injury proposed that lymphatics may attenuate tissue edema inflammatory mechanisms after injury. Nevertheless, through which hypoxic conditions affect lymphangiogenesis function remain unclear. Here, we aimed to characterize role AM (adrenomedullin) decoy receptor ACKR3 (atypical chemokine receptor-3) in response...
Abstract Placenta development is characterized by extensive angiogenesis and vascularization but if these processes are compromised placental dysfunction occurs, which the underlying cause of pregnancy complications such as preeclampsia intrauterine growth restriction. Dysregulation has emerged one main pathophysiological features in insufficiency its clinical consequences. The signaling axis initiated chemokine ligand 12 (CXCL12) receptor CXCR4 stimulates other tissues, may be central to...
Chemokine (C-X-C motif) ligand 12 (CXCL12) and its receptor, chemokine receptor 4 (CXCR4), are involved in significant biological processes associated with early pregnancy including increasing trophoblast invasion stimulating placental vascularization. To further elucidate functions of CXCL12-CXCR4 signaling during gestation, our objective was to inhibit CXCR4 vivo using a antagonist, AMD3100. We hypothesized that inhibition would negatively affect angiogenic factor regulation imperative for...
Long chain n-3 fatty acids are beneficial to mammals because of their anti-inflammatory role.However, whether flaxseed oil, which is rich in short acids, has such a role, it not been extensively examined.This study investigated the supplementation oil on regulation genes involved inflammatory responses as heat shock proteins (HSP90 and HSP70) interleukin (IL1β) white blood cells dogs.Five beagles 5 greyhounds were supplemented with Melrose ® at rate 100 mL/kg food for 21 days.The was...
Abstract Early pregnancy features complex signaling between fetal trophoblast cells and maternal endometrium directing major peri-implantation events including localized inflammation remodeling to establish proper placental development. Proinflammatory mediators are important for conceptus attachment, but a more precise understanding of molecular pathways regulating this process is needed understand how the becomes receptive implantation. Both chemokine ligand 12 (CXCL12) its receptor CXCR4...
Abstract Adrenomedullin (ADM) is an evolutionarily conserved multifunctional peptide hormone that regulates implantation, embryo spacing, and placentation in humans rodents. However, the potential roles of ADM implantation pigs, as a litter-bearing species, are not known. This study determined abundances uterine luminal fluid, patterns expression its receptor components (CALCRL, RAMP2, RAMP3, ACKR3) uteri from cyclic pregnant gilts, well conceptuses (embryonic/fetus extra-embryonic...
Chemokines help coordinate inflammation within the fetal-maternal microenvironment during gestation. The chemokine CXCL12 signaling through its receptor CXCR4 regulates inflammatory activity, but this phenomenon is not well understood pregnancy, and there are no reports exploring role of pair in peripheral immune tolerance Herein, we hypothesize that intrauterine CXCL12-CXCR4 governs local systemic immunomodulatory dynamics early gestation ewes.Osmotic pumps were surgically installed for...
ABSTRACT Regenerating coronary blood vessels has the potential to ameliorate ischemic heart disease, yet there is currently no method of stimulating clinically effective cardiac angiogenesisis. Endocardial cells— a particularly plastic cell type during development—line lumen and are natural vessel progenitors. Their intrinsic angiogenic lost in adults, but studying endocardial- to-coronary developmental pathway could identify methods re-instating this process diseased hearts. Here, we use...
Abstract Adequate corpus luteum (CL) function is paramount to successful pregnancy. Structural and functional CL integrity controlled by diverse cell types that contribute respond the local cytokine milieu. The chemokine ligand 12 (CXCL12) receptor, CXCR4, are modulators of inflammation survival, but little understood about CXCL12-CXCR4 axis regulation. Corpora lutea from control nonpregnant ewes ( n = 5; day 10 estrous cycle (D10C)) pregnant 5/day) on days 20 (D20P) 30 (D30P) post-breeding...
2. Abstract Background Ischemic heart disease is a prevalent cause of death and disability worldwide. Recent studies reported rapid expansion the cardiac lymphatic network upon ischemic injury proposed that lymphatics may attenuate tissue edema inflammatory mechanisms after injury. Nevertheless, through which hypoxic conditions affect lymphangiogenesis function remain unclear. Here, we aimed to characterize role adrenomedullin decoy receptor atypical chemokine 3 (ACKR3) in response following...
The present studies aim to (1) determine expression of (C-X-C motif) Ligand 12 (CXCL12), CXCR4, and inflammatory cytokines in corpus luteum (CL) fetal-maternal interface during early pregnancy when CXCR4 signaling is inhibited ewes, (2) alterations CL cytokine using an vivo model with hCG-stimulated P4 levels. Several human highlight CXCL12-CXCR4 regulating production, but whether similar mechanisms occur livestock uncertain. Our laboratory reported activation axis at the sheep this involved...
The objective of this study was to evaluate the effects rumen-protected L-Leu on plasma branched-chain AA concentrations and rumen fermentation characteristics lambs. Four ruminally-cannulated wether lambs (34 ± 2.4 kg BW) were used in a 4 × Latin square. Each period consisted 7 d: 5 d for adaptation, 1 collections, rest. Lambs fed basal diet (corn grain alfalfa hay; 0.6 kg/d DM) supplements (0.1 containing no added leucine (CON), 6 g/d unprotected (UP-LEU), 18 ruminally-protected (RP-LEU),...
Implantation and placentation is a complex process, involving various signaling molecules, many of which have immune function. During this an increase in cells at the fetal/maternal interface occurs, may immunoprotect fetus as well promote placental vascularization. Chemokines their receptors are pivotal factors implantation vascularization placenta. Chemokine receptor 4 (CXCR4) up regulated endometrium during has only one recognized ligand, CXCL12. In human trophoblast cells, CXCL12/CXCR4...