A5010592723- Radiomics and Machine Learning in Medical Imaging
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Brain Tumor Detection and Classification
- Medical Imaging Techniques and Applications
- Dental Radiography and Imaging
- Trauma and Emergency Care Studies
- Dental Anxiety and Anesthesia Techniques
- MRI in cancer diagnosis
- Dental Research and COVID-19
- Acute Kidney Injury Research
- Pelvic and Acetabular Injuries
- Cardiac, Anesthesia and Surgical Outcomes
- Oral and Maxillofacial Pathology
- Sinusitis and nasal conditions
- Cancer Genomics and Diagnostics
- Autism Spectrum Disorder Research
- Periodontal Regeneration and Treatments
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Obsessive-Compulsive Spectrum Disorders
- Endodontics and Root Canal Treatments
- Hip and Femur Fractures
- Advanced Radiotherapy Techniques
- Neuroblastoma Research and Treatments
- Head and Neck Surgical Oncology
Yale University
2021-2024
Saveetha University
2020-2022
University of California, Irvine Medical Center
2019-2021
University of California, Irvine
2019-2020
Stanford University
2020
Abstract Resection and whole brain radiotherapy (WBRT) are standard treatments for metastases (BM) but associated with cognitive side effects. Stereotactic radiosurgery (SRS) uses a targeted approach less effects than WBRT. SRS requires precise identification delineation of BM. While artificial intelligence (AI) algorithms have been developed this, their clinical adoption is limited due to poor model performance in the setting. The limitations often quality datasets used training AI network....
Clinical monitoring of metastatic disease to the brain can be a laborious and time-consuming process, especially in cases involving multiple metastases when assessment is performed manually. The Response Assessment Neuro-Oncology Brain Metastases (RANO-BM) guideline, which utilizes unidimensional longest diameter, commonly used clinical research settings evaluate response therapy patients with metastases. However, accurate volumetric lesion surrounding peri-lesional edema holds significant...
The PNOC001 phase II single-arm trial sought to estimate progression-free survival (PFS) associated with everolimus therapy for progressive/recurrent pediatric low-grade glioma (pLGG) on the basis of phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target rapamycin (mTOR) pathway activation as measured by phosphorylated-ribosomal protein S6 and identify prognostic predictive biomarkers.
Objective: While psychiatric disorders have been recognized as a risk factor for COVID-19 outcomes, the impact of substance use (SUD) on outcomes has not, to date, examined in systematic manner. We association between SUD (cannabis, cocaine, alcohol, opioid, and benzodiazepine) well diagnoses (schizophrenia, mood disorders, anxiety disorders) large, retrospective cohort study. Methods: COVID-19–positive patients admitted large health care system US January December 2020 were included this...
Studies demonstrate a significant variation in decision-making regarding withdrawal of life-sustaining treatment (WLST) practices for patients with severe traumatic brain injury (TBI). We investigated risk factors associated WLST TBI. hypothesized age ≥65 years would be an independent factor. In addition, we compared survivors who died hospital after to identify potential in-hospital mortality. The Trauma Quality Improvement Program (2010–2016) was queried TBI the head. Patients were by (age...
Aim: The aim of the study is to compare efficacy platelet-rich plasma (PRP) for management internal derangement temporomandibular joint (TMJ). Settings and Design: Thirty-three patients were selected from pool visiting department oral maxillofacial surgery. Simple randomization was done. Subjects Methods: Patients with anterior disc displacement without reduction (DDWOR) indicated arthrocentesis. Group A are treated PRP, B sodium hyaluronate following arthrocentesis, C arthrocentesis alone....
Surgical ciliated cyst (SCC) is a type of true epithelial lined antral cysts, which mostly occurs in maxilla from the sinonasal mucosa and gland, comprising 20% all oral cysts Japan. It also called as postoperative maxillary or paranasal cyst. The etiology believed to be post trauma surgery region antrum.Patient's concern less evident this cystic pathology, because even though an aggressive cyst, presents with fewer symptoms that can uncomfortable patient push them seek medical attention....
Abstract Gliomas with CDKN2A mutations are known to have worse prognosis but imaging features of these gliomas unknown. Our goal is identify specific qualitative biomarkers in glioblastomas using a new informatics workflow that enables rapid analysis Visually AcceSAble Rembrandtr Images (VASARI) for large datasets PACS. Sixty nine patients undergoing GBM resection status determined by whole-exome sequencing were included. GBMs on magnetic resonance images automatically 3D segmented deep...
Tumor size of 8 cm or greater is a risk factor for recurrence after thymoma resection, but the role induction therapy large thymomas not well defined. This study tested hypothesis that and larger improves survival.The use patients treated with surgical resection Masaoka stage I-III in National Cancer Database between 2006-2013 was evaluated using logistic regression, Kaplan-Meier analysis, Cox-proportional hazards methods.Of 1,849 who met inclusion criteria, 582 (31.5%) had tumors ≥8 cm....
In highly developed countries, as many 16 percent of children are physically abused each year. Traumatic brain injury (TBI) is the most common in non-accidental trauma (NAT) and responsible for 80 fatal NAT cases, with deaths occurring younger than three years old. Cases abusers who refuse withdrawal life-sustaining medical treatment (LSMT) to avoid criminal charges have previously been reported. Therefore, we hypothesized that associated a lower risk LSMT pediatric TBI.The Trauma Quality...
<h3>BACKGROUND AND PURPOSE:</h3> Response on imaging is widely used to evaluate treatment efficacy in clinical trials of pediatric gliomas. While conventional criteria rely 2D measurements, volumetric analysis may provide a more comprehensive response assessment. There sparse research the role volumetrics Our purpose was compare and with assessment neuroradiologists using Brain Tumor Reporting Data System (BT-RADS) <i>BRAF</i> V600E-mutant <h3>MATERIALS METHODS:</h3> Manual segmentations...
Abstract BACKGROUND Pediatric diffuse midline glioma (DMG) has a poor prognosis with radiotherapy as the standard of palliative care. Radiation strategies using individual geometric doseshaping have potential to maximize patient benefit. This study aimed establish proof-of-principle generate clinically relevant anatomical representations progression pediatric DMG magnetic resonance image (MRI) slices through denoising diffusion implicit models (DDIM). METHODS Based on BraTS23 data, we...
Abstract PURPOSE 1-Highlighting the Brain Tumor Segmentation (BraTS) challenge; past, present and future. 2- Emergence of ASNR-MICCAI BraTS-METS 2023 challenge with discussing our experience. 3-Discussing how to overcome it. 4- Highlighting administrative technical challenges for sharing data.4- Reviewing educational initiatives challenge. CLINICAL RELEVANCE/APPLICATION challenge: History BraTS evolution its opensource datasets, The components. workflow. How we used cumulative experience run...
Accurate response assessment is critical in pediatric low-grade glioma (pLGG) as there significant morbidity associated with continued treatment. Current standards for rely on 2D measurements. Given the heterogenous nature of pLGG, volumetric treatment may prove more effective. In this study, we compared and methods assessing patients from PNOC-002 clinical trial pLGG. We analyzed quantitative differences between measurements tumor volume percent change post-treatment. also classification...
Recent development of Machine Learning (ML) tools for analysis CNS tumors demonstrates great potential benefit to research and clinical practice but has been hindered by a lack external validation. There is critical need open access large individual hospital-based datasets with expert annotations. Here, we present the Yale Glioma Dataset, database 1,033 patients featuring annotated segmentations on FLAIR T1 post-gadolinium, tumor grading classification, further information. Open this will...
Abstract Background Glioma, the most prevalent primary brain tumor, poses challenges in prognosis, particularly high-grade subclass, despite advanced treatments. The recent shift tumor classification underscores crucial role of isocitrate dehydrogenase (IDH) mutation status clinical care glioma patients. However, conventional methods for determining IDH status, including biopsy, have limitations. Exploring use machine learning (ML) on magnetic resonance imaging to predict shows promise but...
Abstract BACKGROUND Longitudinal assessment and reporting of brain metastases (BM) are prerequisites for a successful treatment regimen but exhibit inter-observer variability laborious. This study aimed to evaluate the workflow efficiency gains facilitated by PACS-integrated artificial intelligence-enabled Lesion Tracking Tool (AI-LTT) longitudinal BM monitoring, focusing on accuracy in comparison fully manual measurements their inter-rater post-Gamma Knife radiosurgery (GKR) patients....
Motivation: Pediatric diffuse midline gliomas are associated with a poor prognosis, leaving radiotherapy as standard of palliative care. Personalized radiation regimes could maximize the benefit for patient, and consequently improve clinical outcomes. Goal(s): This study explores state-of-the-art computer vision method to predict anatomical growth tumors which inform tailored treatments. Approach: A denoising diffusion implicit model is employed generate realistic, high-quality magnetic...