A5023721120- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Cellular and Composite Structures
- Microfluidic and Bio-sensing Technologies
- High-Velocity Impact and Material Behavior
- Fluid Dynamics Simulations and Interactions
- Topology Optimization in Engineering
- Gas Dynamics and Kinetic Theory
- Rocket and propulsion systems research
- Aeroelasticity and Vibration Control
- Shape Memory Alloy Transformations
- Composite Material Mechanics
- Titanium Alloys Microstructure and Properties
- Acoustic Wave Phenomena Research
- Metallurgy and Material Forming
- Structural Response to Dynamic Loads
- Computational Fluid Dynamics and Aerodynamics
- Additive Manufacturing and 3D Printing Technologies
- Numerical methods in engineering
- Advanced Materials and Mechanics
- Transportation Safety and Impact Analysis
- Structural Analysis and Optimization
- Calcium Carbonate Crystallization and Inhibition
- Additive Manufacturing Materials and Processes
- Polymer composites and self-healing
Italian Aerospace Research Centre
2010-2021
Sapienza University of Rome
2021
University of Cambridge
2015-2020
Innova (Italy)
2016-2020
Embraer (Brazil)
2017
McGill University
2011-2013
The ability of cells to orient in response mechanical stimuli is essential embryonic development, cell migration, mechanotransduction, and other critical physiologic functions a range organs. Endothelial cells, fibroblasts, mesenchymal stem osteoblasts all perpendicular an applied cyclic stretch when plated on stretchable elastic substrates, suggesting common underlying mechanism. However, many these same parallel vivo 3D culture, compelling explanation for the different orientation...
Cells are quintessential examples of out-of-equilibrium systems, but they maintain a homeostatic state over timescale hours to days. As consequence, the statistics all observables is remarkably consistent. Here, we develop statistical mechanics framework for living cells by including constraint that exists interphase period cell cycle. The consequence introduction concept ensemble and an associated temperature, along with formalism (dynamic) equilibrium intervenes allow evade thermodynamic...
In the past few decades, several concepts for morphing wings have been proposed with aim of improving structural and aerodynamic performance conventional aircraft wings. One most interesting challenges in design a wing is represented by skin, which needs to meet specific deformation requirements. particular when involves changes cord or curvature, skin required undergo large recoverable actuation direction, while maintaining desired shape strength others. promising material concept that can...
We analyse the response of osteoblasts on grooved substrates via a model that accounts for cooperative feedback between intracellular signalling, focal adhesion development and stress fibre contractility. The substrate is modelled as pattern alternating strips which cell can adhere inhibited. coupled modelling scheme shown to capture some key experimental observations including (i) observation orient themselves randomly with groove pitches less than about 150 nm but they align direction...
Abstract This paper deals with the test and simulation of a full-scale WG30 helicopter impacting on water vertical velocity 8 m/s. The first part is devoted to preparation experimental data measured at CIRA. instrumentations specimen conditions are briefly discussed. After an overall description impact sequence, quantitative results including acceleration floor pressure time histories as well measurements anthropomorphic dummy presented. Finally, pictures showing main damage complete tested...
Commitment of stem cells to different lineages is inherently stochastic but regulated by a range environmental bio/chemo/mechanical cues. Here, we develop an integrated modelling framework for predicting the differentiation hMSCs in response cues, including sizes adhesive islands, stiffness substrates and treatment with ROCK inhibitors both growth mixed media. The statistical analyses fluctuations cell morphologies over approximately 24 h period after seeding specific environment uses...
In this article a finite element implementation of multivariant constitutive model shape memory alloys for mono-dimensional is presented. The has been implemented by writing the kinetic law and equilibrium equation in rate form integrating along thermomechanical load path. allows to simulate both operation isothermal condition, full or partial pseudoelastic recover behavior alloy’s wire mixed thermal mechanical application such as cyclic activations against structure. developed suitable...
Abstract We have analysed the response of cells on a bed micro-posts idealized as Winkler foundation using homeostatic mechanics framework. The framework enables quantitative estimates stochastic along with coupled analysis cell spreading, contractility and mechano-sensitivity. In particular model is shown to accurately predict that: (i) extent actin polymerisation well traction forces that exert increase increasing stiffness foundation; (ii) are primarily concentrated periphery; (iii) while...
Lattice materials are characterized at the microscopic level by a regular pattern of voids confined walls. Recent rapid prototyping techniques allow their manufacturing from wide range solid materials, ensuring high degrees accuracy and limited costs. The microstructure lattice material permits to obtain macroscopic properties structural performance, such as very stiffness weight ratios, highly anisotropy, specific energy dissipation capability an extended elastic range, which cannot be...
In order to improve the level of confidence in design one most critical technology for re-entry space vehicles, a dedicated flight experiment on shock wave boundary layer interaction phenomenon be flown EXPERT capsule has been conceived. As matter fact, common approach vehicle is based ground experimental tests, computational predictions and ground-to-flight extrapolation methodologies even though modern foresees such tools by validating them with respect experiments. At moment lack...