Prospective trials evaluating efficacy of specific diet restriction in functional dyspepsia (FD) are scarce. We aimed to assess low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) FD, compared with traditional dietary advice (TDA).In this prospective, single-blind trial, patients FD (Rome IV) were randomized into FODMAP (LFD) TDA groups, for 4 weeks (phase I). In phase II (4-12 weeks), LFD group was advised systematic re-introduction FODMAPs. Symptom...

Esophageal variceal bleeding is a common reason for hospitalization in patients with cirrhosis. The main objective of this study was to analyze the effects gender differences on outcomes hospitalizations related United States.A retrospective observational cohort performed using National Inpatient Sample (NIS) database all discharge diagnosis esophageal varices hemorrhage from 2016 2019. primary outcome in-hospital mortality, while secondary included rate early endoscopy (defined as less than...

Background: Despite the use of new immunotherapies, hepatocellular carcinoma (HCC) has a poor survival rate. Through multiple molecular mechanisms, aspirin (ASA) demonstrated reduced incidence HCC, however, impact long-term ASA on in-hospital outcomes not been studied. Methods: We queried National Inpatient Sample (NIS) database from 2016 to 2020 identify patients with HCC. Patients were stratified into two groups, based use. Information was collected regarding patient demographics,...

Summary Despite advancing treatment methods, esophageal cancer (EC) maintains a high mortality rate and poor prognosis. Through various mechanisms, aspirin has been suggested to have chemopreventive effect on EC. However, the long-term impact, particularly regarding of metastasis, needs be further elucidated. NIS 2016–2020 was used identify adult patients (age > 18 years) with EC using ICD-10 codes. Patients missing demographics were excluded. stratified into two groups based use....

The utility of CD19-targeted chimeric antigen receptor T-cell (CAR-T cell) therapy in the management refractory/relapsed B-cell malignancies has increased tremendously recent times. In addition to cytokine release syndrome (CRS), neurotoxicity, and infections, CAR-T cell patients develop cytopenias, with about 15% continuing have severe cytopenias up three months after treatment. Retrospective reviews reported development myelodysplastic (MDS) undergoing therapy. Here, we describe four cases...

Our case report is of an elderly male with a history IgM κ lymphoplasmacytic lymphoma (LPL) presenting generalized neuropathy and weakness. Due to his LPL worsening renal function, he underwent biopsy revealing the presence μ heavy λ light chains, diagnosis amyloidosis unbound & chains (AHL), rare type amyloidosis. His bone marrow demonstrated chain restriction by flow cytometry amyloid deposition. The patient's serum had elevated free (FLC) ratio 3.17. Serum immunofixation was positive for...

30 Background: Genomic testing through the employment of somatic and germline has become increasingly relevant in determining prognosis targeted therapies for advanced prostate cancer patients. Prostate health disparities resulting worse presentations clinical outcomes have been observed HA compared to NHW. Understanding prevalence different genomic alterations is paramount bridge gap between two ethnic groups. Methods: This a retrospective analysis 190 metastatic adenocarcinoma patients...

A patient with a history of Mandibular hypoplasia, Deafness, Progeroid Features Associated Lipodystrophy Syndrome (MDPL), familial lipodystrophy presented hypertriglyceridemia induced pancreatitis triglycerides in the 3000s. This occurs due to mutation POLD1 gene (DNA polymerase delta 1). MDPL, hypertriglyceridemia, pancreatitis, POLD1.

Background: Clinical experience suggests an increased hospitalization rate for alcohol-related hepatitis (AH) in the winter months; however, seasonal variations prevalence of hospitalizations AH have not been described previously. We hypothesized that would be higher months due to holiday season and alcohol sales. Methods: Patients with primary or secondary discharge diagnoses were included study (International Classification Diseases, Modification-10th Revision codes K70.4 K70.1) between...

Hodgkin lymphoma (HL) is a hematologic malignancy that comprises about 10% of all lymphomas with the most common type being classical HL (cHL). The typical clinical presentation cHL involves multiple region lymphadenopathy and chest mass found on imaging. However, not patients present symptomology which poses diagnostic challenge. Extranodal HL, especially primary bone marrow (PBMHL), has been described in immunocompromised human immunodeficiency virus (HIV). In this case report, we PBMHL an...

Introduction Multiple studies have shown that outcomes of various diseases differ by the hospital teaching status. However, not much is known about effects status on acute pancreatitis (AP). The aim this study was to identify if there an effect AP. Methods National Inpatient Sample (NIS) database used patients with a discharge diagnosis AP from 2016 2019. Patients were classified according whether they admitted hospitals (TH) or non-teaching (NTH). Study length stay (LOS), total...

Acute pancreatitis (AP) carries a significant morbidity and mortality worldwide. AP is potential complication of hematopoietic stem cell transplantation (HSCT) although its incidence remains unclear. HSCT recipients are at increased risk due to various factors but the effect on resource utilization in adult population has not been studied. We investigated impact hospitalization outcomes among patients following HSCT.We queried National Inpatient Sample (NIS) database using International...

e19507 Background: Secondary CNS lymphoma (SCNSL) in setting of relapsed, refractory (R/R) B cell has unmet needs as this disease state a poor prognosis with reported median survival 2 to 5 months. Historically, the mainstay treatment for SCNSL R/R included high dose methotrexate, whole brain radiation (WBRT), and/or chemotherapy followed by autologous stem transplant. More recently, chimeric antigen receptor (CAR)-T therapy gained attention new modality patients SCNSL. The first two CAR-T...

Introduction: Portal vein thrombosis (PVT) is a well-known complication in patients with acute pancreatitis (AP). Limited data exist on the incidence and factors associated PVT AP. We investigate clinical predictors of hospitalized AP between 2016-2019. Methods: queried 2016-2019 National Inpatient Sample (NIS) database using ICD-10 codes. All adult diagnosis (ICD10 K85) were included, while chronic excluded from analysis. studied demographics, comorbidities, complications, interventions...

Introduction: Prior literature suggests that cannabis use may be associated with decreased progression of liver fibrosis in chronic disease patients. The effect on hospital outcomes patients acute failure (ACLF) has not been previously studied. Methods: We queried the National Inpatient Sample (NIS) database using ICD-10 codes. Acute was defined as presence renal or hepatic encephalopathy and one other organ dysfunction two non-renal failures cirrhosis a decompensating event. Decompensating...

31 Background: Multiple retrospective studies conducted have demonstrated disparities in access to care and treatment rates for prostate cancer between HA NHW. We sought understand the differences presenting characteristics, prognosis, outcomes two ethnic groups who presented University of Arizona Cancer Center (UACC), which serves a large Hispanic community. Methods: A analysis mHSPC adenocarcinoma patients UACC from 2016 2022 was conducted. Patients must had genetic testing be included....

e16162 Background: Despite the use of new immunotherapies, hepatocellular carcinoma (HCC) has a poor survival rate. Through multiple molecular mechanisms, aspirin (ASA) demonstrated reduced incidence HCC, however, impact long-term on in-hospital outcomes not been studied. Methods: We queried National Inpatient Sample (NIS) database from 2016 to 2020 identify patients with HCC. Patients were stratified into two groups, based use. Information was collected regarding patient demographics,...

e19064 Background: Hematopoietic stem cell transplant (HSCT) recipients are at a higher risk of clostridium difficile infection (CDI). The incidence CDI in allogenic SCT has been shown to be about 2-fold compared autologous certain studies. These differences can attributed myeloablative chemotherapy and increased duration immunosuppression patients. In this study we evaluate the impact on in-hospital outcomes these two groups Methods: We included all patients with prior diagnosis or...