A5046186762- Cancer and Skin Lesions
- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- Sarcoma Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Lymphoma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Tumors and Oncological Cases
- Gastrointestinal Tumor Research and Treatment
- Soft tissue tumor case studies
- Bone Tumor Diagnosis and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Thyroid Cancer Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Cancer Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Testicular diseases and treatments
- Cancer Treatment and Pharmacology
- Eosinophilic Disorders and Syndromes
- Adrenal and Paraganglionic Tumors
- Neurofibromatosis and Schwannoma Cases
- Genetic and rare skin diseases.
- Meningioma and schwannoma management
University of Naples Federico II
2006-2018
Federico II University Hospital
1999-2017
University of Campania "Luigi Vanvitelli"
2014
University of Minnesota
1988-2004
Ceinge Biotecnologie Avanzate (Italy)
2004
University Hospital of Basel
2004
Fatebenefratelli Hospital
1997
University of Messina
1997
Ospedale Antonio Cardarelli
1994
Alleanza Contro il Cancro
1991
Journal Article Inflammatory Myofibroblastic Tumor (plasma cell granuloma): Clinicopathologic Study of 20 Cases with Immunohistochemical and Ultrastructural Observations Get access Guido Pettinato, M.D., M.D. Department Pathology, 2nd Medical School, University Naples, Italy; the Laboratory Medicine Division Surgical Minnesota Hospital Clinics, Minneapolis, Address reprint requests to Dr. Manivel: Box 76 UMHC, Hospital, 420 Delaware Street, SE, 55455. Search for other works by this author...
PURPOSE We studied retrospectively the interaction between c-erbB2 overexpression and adjuvant tomoxifen in node-negative breast cancer patients enrolled Gruppo Universitario Napoletano 1 (GUN-1) trial. PATIENTS AND METHODS c-erbB2, evaluated by immunohistochemistry 145 of 173 randomly assigned to 2-year tamoxifen or no further therapy, was considered overexpressed if greater than 10% cells showed specific membrane staining. The role each prognostic variable their independent effect were...
Background. This study assessed the prognostic effect of lymphatic and blood vessel invasion (LVI BVI) on survival in a retrospective sample 1408 patients with breast cancer. Methods. Survival analysis was evaluated by univariate (Kaplan-Meier product limit method log rank test) multivariate (Cox model) analysis. Correlations among variables were studied contingency tables statistical significance chi-square test. Results. Lymphatic present 34.2% cases, BVI 4.2%. correlated (P < 0.0001),...
We report 62 cases of invasive micropapillary carcinoma the breast characterized by delicate pseudopapillary structures lacking a fibrovascular core and tubuloalveolar freely floating in clear, empty spaces. All patients but 1 were women (median age, 57 years; range, 25–89 years). Tumor size ranged from 0.7 to 10 cm (median, 2.8 cm); 54 (87%) grade 3. Psammoma bodies identified 29 (47%). Focal massive lymphatic permeation was present 39 (63%). Architectural features retained node metastases,...
We report 62 cases of invasive micropapillary carcinoma the breast characterized by delicate pseudopapillary structures lacking a fibrovascular core and tubuloalveolar freely floating in clear, empty spaces. All patients but 1 were women (median age, 57 years; range, 25–89 years). Tumor size ranged from 0.7 to 10 cm (median, 2.8 cm); 54 (87%) grade 3. Psammoma bodies identified 29 (47%). Focal massive lymphatic permeation was present 39 (63%). Architectural features retained node metastases,...
The adenoid variant of squamous cell carcinoma has been well-documented in several anatomic sites, including the skin. This tumor is characterized by acantholytic arrays neoplastic keratinocytes that form pseudoglandular profiles. Although it typically confused with adenocarcinomas, also may be mistaken for malignant vascular proliferations. report concerns six cutaneous carcinomas closely simulated angiosarcomas on conventional histologic examination. They arose sun-exposed skin areas...
Ten cases of melanotic neuroectodermal tumor infancy (MNTI) were studied. There nine males and one female ranging in age from 2 weeks to 10 months; patient was 8 years old. Sites origin the maxilla (five), epididymis (two), mandible (one), skull soft tissues cheek (one). Six tumors recurred 1 18 months after diagnosis. One had widespread dissemination. Electron microscopic study four showed cells with melanosomes at various stages maturation, neuroblastic features, including neurosecretory...
Cutaneous adenoid squamous carcinoma (ASCC) is a distinctive neoplasm featuring tumor cell acantholysis. Because this lesion occasionally may prove troublesome diagnostically, we studied the clinical, histologic, and immunohistochemical features of 55 examples in order to further elucidate its characteristics. ASCC most often occurred skin head neck elderly patients. Of 49 patients series, 46 were men 3 women; their ages at diagnosis ranged from 25 90 yr, with mean 71. Six individuals had 2...
The expression of growth factors, such as transforming factor α (TGFα), amphiregulin (AR) and CRIPTO, a type-1 tyrosine-kinase receptor-(erbB-2), tumor-suppressor gene (p53), that have been implicated in the development and/or progression breast cancer, was evaluated by immunohistochemistry 100 human primary infiltrating carcinomas (IBC). AR CRIPTO immunoreactivity also assessed 55 ductal situ (DCIS). Within IBC, 80, 50, 73, 17, 34 tumors expressed moderate to high levels TGFα, AR, erbB-2,...
Objective : The somatic point mutation in the BRAF gene, which results a valine-to-glutamate substitution at residue 600 (BRAF V600E ), is an ideal hallmark of papillary thyroid carcinoma (PTC). However, its prevalence varyingly reported different studies, and expression follicular variant PTC controversial, reducing potential usefulness as diagnostic marker. Design methods We developed assay based on mutant allele-specific PCR amplification (MASA) to detect mutation. compared sensitivity...
The sensitivity of lymph node core-needle biopsy under imaging guidance requires validation. We employed power Doppler ultrasonography (PDUS) to select the most suspected malignancy and histologically characterize it through use large cutting needle. Institutional review board approval informed consent were obtained for this randomized clinical trial. In a single center between 1 January 2009 31 December 2015, patients with enlargement lymphoma randomly assigned (1:1) either standard surgery...
The first case of plasma cell granuloma (PCG) the breast is presented. lesion was seen as a circumscribed firm mass in right 29-year-old woman. Histologically, prominent infiltrate fibrous hyalinized stroma that contained spindle- and large stellateshaped stromal cells with bizarre nuclei. Immunohistochemical study demonstrated polyclonal nature characterized myofibroblasts. these confirmed ultrastructurally. PCG should be considered analogous to inflammatory pseudotumors lung extrapulmonary sites.