A5016148601- Systemic Sclerosis and Related Diseases
- Inflammatory Myopathies and Dermatomyositis
- Autoimmune Bullous Skin Diseases
- Systemic Lupus Erythematosus Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Psoriasis: Treatment and Pathogenesis
- Dermatologic Treatments and Research
- Spondyloarthritis Studies and Treatments
- Inflammatory mediators and NSAID effects
- Autoimmune and Inflammatory Disorders Research
- Urticaria and Related Conditions
- Peroxisome Proliferator-Activated Receptors
- Rheumatoid Arthritis Research and Therapies
- Osteoarthritis Treatment and Mechanisms
- T-cell and B-cell Immunology
- Cholesterol and Lipid Metabolism
- Celiac Disease Research and Management
- Orthopedic Infections and Treatments
- SARS-CoV-2 and COVID-19 Research
- Ion channel regulation and function
- Cancer Diagnosis and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Cytokine Signaling Pathways and Interactions
- COVID-19 Clinical Research Studies
- Peripheral Neuropathies and Disorders
University Hospital of Larissa
2010-2025
University of Thessaly
2016-2025
RMIT University
2015
Instituto de Investigación Biomédica de A Coruña
2010
Breg cells, a regulatory cell subset that produces interleukin-10 (IL-10), play significant role in suppressing autoimmune responses and preventing autoimmunity. This study was undertaken to examine the number function of cells patients with systemic sclerosis (SSc), disease many autoantibodies.Forty-five SSc (12 early SSc, 33 established including 16 SSc-associated pulmonary fibrosis [PF]), 12 healthy control subjects, 10 rheumatoid arthritis (RA)-associated PF were studied. The phenotypes...
Background: Autoantibodies (autoAbs) help in diagnosis and predicting clinical phenotypes systemic sclerosis (SSc).Aim of the study: To determine utility 13 SSc-related autoAbs SSc patients.Material methods: A total 131 consecutive patients with (111 female, mean age 58.1 ± 14 years; 49 diffused cutaneous [dcSSc] 82 limited [lcSSc]) were analysed by a multiplex line immunoassay (Euroimmun) for autoantibodies against antigens. 22 primary Raynaud phenomenon (RP), healthy controls also...
Τo report outcomes of breakthrough COVID-19 in comparison with unvaccinated patients systemic rheumatic diseases (SRDs).Patients SRD (vaccinated and unvaccinated) were included by their rheumatologists a registry operated the Greek Rheumatology Society voluntarily basis. Type, date doses SARS-CoV-2 vaccines recorded, demographics, type SRD, concurrent treatment, comorbidities (hospitalisation, need for oxygen supplementation death) compared between vaccinated patients.Between 1 March 2020 31...
Altered lipid metabolism has been implicated as a critical player in osteoarthritis (OA). Our study aimed to investigate the expression of genes regulating cholesterol efflux human chondrocytes and effect an LXR agonist on accumulation osteoarthritic chondrocytes. ATP-binding-cassette transporter A1 (ABCA1), apolipoprotein (ApoA1), liver X receptors (LXRalpha LXRbeta) mRNA levels were evaluated using real-time polymerase chain reaction (PCR) ApoA1 protein by Western blot analysis normal...
The PERSEIDS study aimed to estimate incidence/prevalence of interstitial lung diseases (ILDs), fibrosing (F-ILDs), idiopathic pulmonary fibrosis (IPF), systemic sclerosis-associated ILD (SSc-ILD), other non-IPF F-ILDs and their progressive-fibrosing (PF) forms in six European countries, as current data are scarce. This retrospective, two-phase used aggregate (2014-2018). In Phase 1, incident/prevalent cases ILDs above were identified from clinical databases through an algorithm based on...
Antibiotic-impregnated cement is used frequently in revision procedures of infected total hip and knee arthroplasties. Local antibiotic treatment as effective the use systemic antibiotics. The purpose such to provide high tissue concentrations antibiotics minimize toxicity, especially nephrotoxicity. Though antibiotic-impregnated considered safe terms nephrotoxicity, two cases that have implicated aminoglycoside-impregnated acute renal failure (ARF) after surgery for an arthroplasty (TKA)...
Abstract The aim of our study was to evaluate the in vitro effect an HMG‐CoA reductase inhibitor, atorvastatin, on expression significant anabolic and catabolic genes human osteoarthritic chondrocytes explore metabolic pathways involved this process. Human articular were cultured presence absence atorvastatin (10 50 µmol/L) for 24 h. Metalloproteinase 13 (MMP‐13), collagen type II (COL2A1), aggrecan (AGC) mRNA levels evaluated by real‐time PCR, protein Western blot analysis. IL‐1β culture...
Abstract Objectives Psoriatic arthritis (PsA) and psoriasis are immune-mediated inflammatory diseases sharing common immunological mechanisms. Regulatory B cells (Breg cells) producing IL–10 (B10 cells), a critical anti-inflammatory B-cell subset, were found to be decreased in both PsA psoriasis. Apremilast, phosphodiesterase-4(PDE4) inhibitor, increases IL-10 therefore, we examined the effect of apremilast on Breg cells. Methods Fifty patients, including 20 with 30 psoriasis, included...
Abstract Objective To present the characteristics of patients with potential difficult-to-treat (D2T) PsA. Methods We used data from Greek multicentre registry PsA patients. D2T was defined as follows: at least 6 months’ disease duration, who have failed to one conventional synthetic DMARD and two biologic DMARDs/targeted DMARDs a different mechanism action either moderate activity (MODA) DAPSA (Disease Activity index in PSoriatic Arthritis) >14, and/or are not minimal (MDA)....
Abstract Sarcopenia is characterized by loss of muscle mass and reduced function, presenting various adverse events, especially when inflammation present. The present study aimed to determine the prevalence sarcopenia sarcopenic obesity among patients with rheumatic musculoskeletal diseases (RMDs) identify risk for using two screening tools Strength, assistance walking, rising from a chair, climbing stairs, falls (SARC-F) Mini Risk Assessment (MSRA). In this single-center cross-sectional...
Abstract Objective To present the clinical and imaging characteristics of patients with Axial Psoriatic Arthritis (PsA) to identify possible subtypes. Methods Data were retrieved from Greek-multicentre PsA study. (axPsA) was defined as (CASPAR criteria) accompanied by inflammatory back pain (present or ever) positive findings sacroiliac joints and/or spine (MRI: active inflammation spine; X-rays: 1984 New York-criteria for radiographic sacroiliitis presence syndesmophytes in spine)....
Abstract Introduction This study aimed to determine whether the introduction of anti-SARS-CoV-2 vaccines and dominance omicron variant had a significant impact on outcome COVID-19 in patients with systemic autoimmune rheumatic diseases (SAIRDs). Methods Using data entered Greek Rheumatology Society registry, we investigated incidence hospitalization death due COVID-19, during successive periods pandemic according prevalent strain (wild-type, Alpha, Delta, Omicron) vaccinated unvaccinated...