A5051450736- Ovarian cancer diagnosis and treatment
- FOXO transcription factor regulation
- Cancer-related molecular mechanisms research
- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- Cancer Mechanisms and Therapy
- Genetic factors in colorectal cancer
- TGF-β signaling in diseases
- Pancreatic and Hepatic Oncology Research
- Estrogen and related hormone effects
- Endometrial and Cervical Cancer Treatments
- Biomedical Text Mining and Ontologies
- Advanced Breast Cancer Therapies
- Reproductive System and Pregnancy
Roche (France)
2013-2023
Centre de Recherche en Cancérologie de Lyon
2013-2015
Centre Léon Bérard
2015
Université Claude Bernard Lyon 1
2015
Inserm
2015
Centre National de la Recherche Scientifique
2015
The Transforming growth factor β (TGFβ) signaling has a paradoxical role in cancer development and outcome. Besides, the prognostic significance of TGFβ1, SMAD4 breast patients is an area many contradictions. transcriptional intermediary 1γ (TIF1γ) thought to interact with TGFβ/SMAD through different mechanisms. Our study aims define TIF1γ expression detect possible interactions among those markers that might affect outcome.Immunohistochemistry was performed on tissue microarray (TMA) blocks...
Granulosa cell tumor (GCT) is a rare and severe form of sex-cord stromal ovarian that characterized by its long natural history tendency to recur years after surgical ablation. Because there no efficient curative treatment beyond surgery, ~20% patients die the consequences their tumor. However, very little known molecular etiology this pathology. About 70% GCT present with elevated circulating estradiol (E2). hormone increase growth progression in number cancers, we investigated possible...
Cancer treatment is constantly evolving toward a more personalized approach based on clinical features, imaging, and genomic pathology information. To ensure the best care for patients, multidisciplinary teams (MDTs) meet regularly to review cases. Notwithstanding, conduction of MDT meetings challenged by medical time restrictions, unavailability critical members, additional administrative work required. These issues may result in members missing information during postponed treatment....
Abstract Background: Ovarian sex cord-stromal tumors (SCSTs) represent about 7% of ovarian tumors. Since the exact diagnosis these rare malignancies is difficult to establish and could modify appropriate therapeutic strategy, GINECO group (Group National Investigators for Cancer Studies) developed Rare tumor Observatory in 2002 which proposes a systematic pathological second opinion all cases diagnosed France. We investigated whether one expert centers (Lyon, France), using evaluation FOXL2...
<sec> <title>BACKGROUND</title> Cancer treatment is constantly evolving toward a more personalized approach based on clinical features, imaging, and genomic pathology information. To ensure the best care for patients, multidisciplinary teams (MDTs) meet regularly to review cases. Notwithstanding, conduction of MDT meetings challenged by medical time restrictions, unavailability critical members, additional administrative work required. These issues may result in members missing information...