A5017841345- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- TGF-β signaling in diseases
- Viral-associated cancers and disorders
- Acute Myeloid Leukemia Research
- RNA modifications and cancer
- Cell death mechanisms and regulation
- PI3K/AKT/mTOR signaling in cancer
- Cancer Cells and Metastasis
- Kruppel-like factors research
- Genomics, phytochemicals, and oxidative stress
- Cancer-related gene regulation
- Endoplasmic Reticulum Stress and Disease
- Immunodeficiency and Autoimmune Disorders
- Mechanisms of cancer metastasis
- Genetic factors in colorectal cancer
- Cancer Research and Treatments
- Chronic Myeloid Leukemia Treatments
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Click Chemistry and Applications
- Cancer-related molecular mechanisms research
- T-cell and Retrovirus Studies
- Pancreatic and Hepatic Oncology Research
- Monoclonal and Polyclonal Antibodies Research
Centre de Recherche en Cancérologie de Lyon
2014-2024
Centre Léon Bérard
2013-2024
Inserm
2014-2024
Centre National de la Recherche Scientifique
2013-2024
Université Claude Bernard Lyon 1
2013-2024
Institut pour l'avancée des biosciences
2000-2013
Babraham Institute
2013
École Normale Supérieure de Lyon
2013
Université Joseph Fourier
2013
Université Grenoble Alpes
2013
Research Article5 April 2011Open Access Down-regulation of BRCA1 expression by miR-146a and miR-146b-5p in triple negative sporadic breast cancers Amandine I. Garcia CNRS UMR5286 Inserm U1052, "Equipe Labellisée LIGUE 2008", University Lyon 1, Cancer Center Lyon, Centre Léon Bérard, France Search for more papers this author Monique Buisson Pascale Bertrand CNRS-CEA UMR 217, Institut de Radiobiologie Cellulaire et Moléculaire, Fontenay-aux-Roses, Ruth Rimokh Etienne Rouleau Laboratoire...
The RNA helicases DDX5 and DDX17 are members of a large family highly conserved proteins that involved in gene-expression regulation; however, their vivo targets activities biological processes such as cell differentiation, which requires reprogramming programs at multiple levels, not well characterized.Here, we uncovered mechanism by cooperate with heterogeneous nuclear ribonucleoprotein (hnRNP) H/F splicing factors to define epithelial-and myoblast-specific subprograms.We then observed...
Summary A chromosomal translocation involving a breakpoint on the long arm of chromosome 5 at position q35 has been reported previously in 17 cases neoplasia. In 14 these involves exchange material between 2 p23 and 5. Most had diagnosed histologically as malignant histiocytosis but it was suggested recently, following study three one author's laboratories, that such tumours are reality lymphoid tumours. present paper we report 12 further neoplasms with 5q35 show all were large cell...
Two cases of non-Hodgkin's lymphoma are reported in which a chromosomal translocation was observed involving the same site (q35) on long arm chromosome 5. The other breakpoint involved 2 (p23) one case and 3 (q12) other. Both were large cell lymphomas expressing CD30 antigen ('Ki-1 lymphoma'). One clearly T lymphoid origin, probably B derived. Ki-1 with 2;5 (involving 5) has been previously, it is suggested that this cytogenetic abnormality may be specifically associated lymphoma. literature...
Dicer, a ribonuclease, is the key enzyme required for biogenesis of microRNAs and small interfering RNAs essential both mammalian development cell differentiation. Recent evidence indicates that Dicer may also be involved in tumourigenesis. However, no studies have examined clinical significance at RNA protein levels breast cancer. In this study, biological prognostic value expression was assessed cancer lines, progression cellular models, two well-characterised sets carcinoma samples...
The Krüppel-like zinc finger protein ZNF217 is a candidate oncogene in breast cancer. In this study, we showed that high levels of expression mRNA are associated with poor prognosis and the development metastases Overexpression cancer cells stimulated migration invasion vitro promoted spontaneous lung or node mice vivo. also epithelial-mesenchymal transition (EMT) human mammary epithelial cells, TGF-β-activated Smad signaling pathway was identified as major driver ZNF217-induced EMT....
FOXL2 mutation has been consistently identified in adult granulosa cell tumours (A-GCTs). DICER1 mutations have described predominantly Sertoli-Leydig (SLCTs). The prognostic implication of these remains uncertain, as moderately sized studies yielded variable outcomes. Our aim was to determine the implications and 156 ovarian sex cord-stromal (SCSTs).FOXL2 were found 94% pathologically confirmed A-GCTs (95/101), one eight juvenile (J-GCTs), two 19 SLCTs. RNase IIIb domain six SLCTs, J-GCTs,...
Inactivation of the Transforming Growth Factor Beta (TGFβ) tumor suppressor pathway contributes to progression Pancreatic Ductal AdenoCarcinoma (PDAC) since it is inactivated in virtually all cases this malignancy. Genetic lesions inactivating contribute pancreatic mouse models. Transcriptional Intermediary 1 gamma (TIF1γ) has recently been proposed be involved TGFβ signaling, functioning as either a positive or negative regulator pathway. Here, we addressed role TIF1γ carcinogenesis. Using...
In metazoans, Bcl-2 family proteins are major regulators of mitochondrially mediated apoptosis; however, their evolution remains poorly understood. Here, we describe the molecular characterization four members in most primitive metazoan, Trichoplax adhaerens All trBcl-2 homologs multimotif group, with trBcl-2L1 and trBcl-2L2 being highly divergent antiapoptotic members, whereas trBcl-2L3 trBcl-2L4 proapoptotic Bax Bak, respectively. trBax expression permeabilizes mitochondrial outer...
We have reported previously the physical interaction of B-cell translocation gene proteins (BTG)1 and BTG2 with mouse protein CAF1 (CCR4-associated factor 1) suggested that these may participate, through their association CAF1, in transcription regulation. Here we describe vitro vivo hPOP2, human paralog hCAF1. The functional relationships between BTG partners hCAF1 hPOP2 were investigated to find out how interactions affect cellular processes, particular defined regions examined expression...
We describe a new monoclonal antibody (designated Bu20a) against bromodeoxyuridine (BrdU). This was selected by screening human tissues using the APAAP technique, and shows no crossreactivity with normal nuclei. It stains BrdU incorporated into nuclei of wide range cell types, including tonsil lymphoid cells, mouse tissues, tumors growing in nude mice. A double-labeling technique is described this which smears or tissue sections are first labeled an immunoperoxidase procedure for cellular...
Invariant natural killer T (iNKT) cells constitute a distinct subset of lymphocytes exhibiting important immune-regulatory functions. Although various steps their differentiation have been well characterized, the factors controlling development remain poorly documented. Here, we show that TGF-β controls program iNKT cells. We demonstrate signaling carefully and specifically orchestrates several cell development. In vivo, this multifaceted role involves concerted action different pathways...
Abstract Intracellular Ca 2+ signaling regulates cell migration by acting on cytoskeleton architecture, directionality and focal adhesions dynamics. In migrating cells, cytosolic pool pulses are described as key components of these effects. Whereas the role mitochondrial calcium homeostasis Mitochondria Cacium Uniporter (MCU) in were recently highlighted vivo using zebrafish model, their implication actin cystokeleton dynamics mammals is not totally characterized. Here, we show that mcu...