A5102811097- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Urological Disorders and Treatments
- Bladder and Urothelial Cancer Treatments
- Osteoarthritis Treatment and Mechanisms
- Urinary and Genital Oncology Studies
- Spinal Fractures and Fixation Techniques
- Plant Toxicity and Pharmacological Properties
- Medical Imaging and Analysis
- Sexual Differentiation and Disorders
- Shoulder Injury and Treatment
- Cervical and Thoracic Myelopathy
- Clinical practice guidelines implementation
- Pain Management and Treatment
University of Pittsburgh Medical Center
2011-2017
Universidade de Fortaleza
2016-2017
Universidade Federal do Ceará
2016
University of Pittsburgh
2007-2013
Pain and Rehabilitation Medicine
2013
National Center for Complementary and Integrative Health
2012
Mechanical forces and inflammatory signaling influence intervertebral disc matrix homeostasis. We hypothesized that annulus fibrosus cells from degenerative discs would have altered responses to mechanical stimuli compared with isolated normal discs.Annulus were New Zealand White rabbits magnetic resonance imaging-confirmed created by annular stab. Cells cultured without (tensile strain). After 4 or 24 hrs, the mRNA expression of inflammatory, catabolic, anabolic genes was measured reverse...
In Brief Study Design. Laboratory based controlled in vivo study. Objective. To determine the effects of oral glucosamine sulfate on intervertebral disc degeneration. Summary Background Data. Although has demonstrated beneficial effect articular cartilage, clinical benefit is uncertain. A Centers for Disease Control report from 2009 reported that many patients are using supplementation low back pain, without significant evidence to support its use. Because degeneration a major contributor we...
to evaluate the effect of L-lysine in bladder and intestinal epithelia rats submitted vesicosigmoidostomy.we divided forty Wistar into four groups: group I - control (Sham); II vesicosigmoidostomy treated with 150mg/kg; III only vesicosigmoidostomy; IV received 150mg/kg. After eight weeks animals were sacrificed.in bladders all operated we observed simple, papillary nodular hyperplasia transitional cells, cell papillomas squamous metaplasia. As for occurrence aberrant crypt foci colons...
To evaluate the effects of L-lysine on intestinal and urothelial epithelium rats subjected to ureterosigmoidostomy (new model for surgical carcinogenesis).Forty-two rats, 9 weeks age, were divided into 6 groups. Animals in groups A, B, C (US) treated with L-lysine, celecoxib H2O, respectively. Groups D, E F (non-operated controls) received The dose was 150 mg/kg that 20 mg/kg. colon analyzed presence aberrant crypt foci (ACF) under a stereomicroscope.The tissue stained hematoxylin eosin PAS...
Purpose: To evaluated the effects of L-lysine on intestinal and urothelial epithelia in cystoplasty rats. Methods: Twenty-eight 9-week-old rats were assigned to 4 groups: Group A (n=8) followed by administration (150 mg/kg body weight gavage) for 30 weeks; B + water C (n=6) D weeks. Results: On histopathology with hematoxylin eosin, mild moderate hyperplasia transitional was observed at site anastomosis all animals submitted (Groups B), but "transitional metaplasia" glandular epithelium more...