A5083411289- Asthma and respiratory diseases
- Mental Health Research Topics
- Inhalation and Respiratory Drug Delivery
- Child and Adolescent Psychosocial and Emotional Development
- Digital Mental Health Interventions
- Heart Rate Variability and Autonomic Control
- Eosinophilic Esophagitis
- Maternal Mental Health During Pregnancy and Postpartum
- Impact of Technology on Adolescents
- Suicide and Self-Harm Studies
- IL-33, ST2, and ILC Pathways
- Attachment and Relationship Dynamics
- Functional Brain Connectivity Studies
- Radiomics and Machine Learning in Medical Imaging
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Child Abuse and Trauma
- Neural and Behavioral Psychology Studies
- Psychological Well-being and Life Satisfaction
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Pharmaceutical studies and practices
- Mental Health Treatment and Access
- Personality Disorders and Psychopathology
- Pharmacological Receptor Mechanisms and Effects
Brigham and Women's Hospital
2008-2025
Harvard University
2020-2025
Binghamton University
2022-2025
McLean Hospital
2020-2022
Harvard University Press
2015
National Jewish Health
1996
University of Colorado Denver
1996
Abstract Background Adolescence is characterized by profound change, including increases in negative emotions. Approximately 84% of American adolescents own a smartphone, which can continuously and unobtrusively track variables potentially predictive heightened emotions (e.g. activity levels, location, pattern phone usage). The extent to built-in smartphone sensors reliably predict states elevated affect an open question. Methods Adolescent participants ( n = 22; ages 13–18) with low high...
Rather than relying on a single psychotherapeutic orientation, most clinicians draw from range of therapeutic approaches to treat their clients. To date, no data-driven approach exists for personalized predictions which skill domain would be therapeutically beneficial given patient. The present study combined ecological momentary assessment (EMA) and machine learning test predicting patient-specific skill-outcome associations.Fifty (Mage = 37 years old, 54% female, 84% White) adults received...
Anhedonia is a core symptom of depression that predicts worse treatment outcomes. Dysfunction in neural reward circuits thought to contribute anhedonia. However, whether laboratory-based assessments anhedonia and reward-related function translate adolescents' subjective affective experiences real-world contexts remains unclear.We recruited sample adolescents (n = 82; ages 12-18; mean 15.83) who varied measured the relationships among clinician-rated self-reported anhedonia, behaviorally...
Abstract In this study, we sought to combine two lines of research better understand risk for the intergenerational transmission depression. The first focuses on role maternal criticism as a potential mechanism depression in youth while second builds from interpersonal and stress generation models regarding impact future escalations criticism. Specifically, examined within transactional mediation model using data multi-wave study. Participants were 251 mother–offspring pairs consisting...
Abstract The goal of this study was to examine age‐related differences in children’s reward processing. Focusing on outcome processing, we used event‐related potentials substages neural response gain versus loss feedback a sample 7–11‐year‐old children ( M = 9.67, SD 1.40) recruited from the community N 234; 47.6% girls, 66.2% non‐Hispanic European American). Using principal components analysis (PCA), focused temporospatial combinations that closely resembled RewP, fb‐P3, and fb‐LPP temporal...
The neurokinin receptors responsible for transducing the airway obstruction resulting from capsaicin infusion were defined in tracheally perfused guinea pig lung. In this lung preparation, buffer is via trachea and allowed to exit through numerous small holes pleural surface; monitored as backpressure (Pao) generated at a constant perfusion flow rate. Infusion of specific NK1 receptor agonist, Sar-9 Met02(11) substance P, resulted an increase Pao; effect was prevented by antagonist CP 99,994...
<h3>Introduction and Objectives</h3> Tezepelumab is a human monoclonal antibody that blocks thymic stromal lymphopoietin (TSLP), an epithelial cytokine involved in asthma pathogenesis. In the phase 3 NAVIGATOR study (NCT03347279), tezepelumab reduced annualized exacerbation rate (AAER) patients with severe, uncontrolled versus placebo, across baseline inflammatory biomarker levels. This <i>post hoc</i> analysis of evaluated AAER receiving or placebo by blood eosinophil counts (BECs)...
Background Non‐suicidal self‐injury (NSSI) is a significant public health concern that thought to increase risk for future self‐injurious behaviors, including suicide attempts. Notably, NSSI especially prevalent among adolescents, which underscores critical need identify modifiable factors could be targeted reduce risk. The current study examined self‐ and co‐regulation of physiological responses during mother‐daughter interactions in adolescent girls with without history NSSI. Methods...
Background: Anhedonia is a core symptom of depression that predicts worse treatment outcomes. Dysfunction in neural reward circuits thought to contribute anhedonia. However, it remains unclear whether laboratory-based assessments anhedonia and reward-related function translate adolescents' subjective affective experiences real-world contexts. Methods: We recruited sample adolescents (ages 12-18; mean=15.83) who varied (N=82) examined the relationships among clinician-rated self-reported...
Objective: Rather than relying on a single psychotherapeutic orientation, most clinicians draw from range of therapeutic approaches to treat their clients. To date, no data-driven approach exists for personalized predictions which skill domain would be therapeutically beneficial given patient. The present study combined ecological momentary assessment (EMA) and machine learning test predicting patient-specific skill-outcome associations.Method: Fifty (Mage= 37 years old, 54% female, 84%...
Adolescence is characterized by profound change, including increases in negative emotions. Approximately 84% of American adolescents own a smartphone, which can continuously and unobtrusively track variables potentially predictive heightened emotions (e.g., activity levels, location, pattern phone usage). The extent to built-in smartphone sensors reliably predict states elevated affect an open question. In this study, adolescent participants (n = 22; ages 13-18) with low high levels...