A5034122308- Autophagy in Disease and Therapy
- Agricultural pest management studies
- Endoplasmic Reticulum Stress and Disease
- Sirtuins and Resveratrol in Medicine
- Insect Resistance and Genetics
- Organoselenium and organotellurium chemistry
- Selenium in Biological Systems
- Biochemical and Structural Characterization
University of Würzburg
2025
Universidade Federal de São Paulo
2022-2025
In this study, cyclometallated gold(III) compounds were evaluated for their capability to promote C-Se coupling reactions under biocompatible conditions, and chemoselectivity towards selenium-containing substrates compared sulfur-containing analogs. The exhibited varying degrees of selectivity compounds, with [Au(bnopy)Cl₂] showing rapid bond formation. Competitive selenium sulfur highlighted the preference selenium, especially [Au(Mephpy)Cl₂], even in presence excess substrates. This was...
In the search for alternatives to overcome challenge imposed by drug resistance development in cancer treatment, modulation of autophagy has emerged as a promising alternative that achieved good results clinical trials. Nevertheless, most these studies have overlooked novel and selective type autophagy: chaperone-mediated (CMA). Following its discovery, research into CMA's contribution tumor progression accelerated rapidly. Therefore, we now understand stress conditions are primary signal...