A5058934280- Parasites and Host Interactions
- Ferroptosis and cancer prognosis
- Helminth infection and control
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Autophagy in Disease and Therapy
- Drug Transport and Resistance Mechanisms
- Vitamin K Research Studies
- Circular RNAs in diseases
- Sirtuins and Resveratrol in Medicine
- Genomics, phytochemicals, and oxidative stress
- Histone Deacetylase Inhibitors Research
- RNA modifications and cancer
- Endoplasmic Reticulum Stress and Disease
- Parasite Biology and Host Interactions
Universidade Federal de São Paulo
2021-2024
Abstract Glioblastoma patients have a poor prognosis mainly due to temozolomide (TMZ) resistance. NRF2 is an important transcript factor involved in chemotherapy resistance its protective role the transcription of genes cellular detoxification and prevention cell death processes, such as ferroptosis. However, relation between iron-dependent glioma still poorly understood. Therefore, this study, we analyzed ferroptosis modulation glioblastoma cells. Two human lines (U251MG T98G) were examined...
In the search for alternatives to overcome challenge imposed by drug resistance development in cancer treatment, modulation of autophagy has emerged as a promising alternative that achieved good results clinical trials. Nevertheless, most these studies have overlooked novel and selective type autophagy: chaperone-mediated (CMA). Following its discovery, research into CMA's contribution tumor progression accelerated rapidly. Therefore, we now understand stress conditions are primary signal...
Abstract Several studies have described the effects of human tumor necrosis factor alpha (hTNF-α) on Schistosoma mansoni . hTNF-α affects worm’s development, metabolism, egg-laying, gene expression and protein phosphorylation. The available data influence egg-laying in S. are controversial, but understanding mechanism regulation this species is essential combating schistosomiasis. We characterized vitro treatment adult worms with different doses (5, 20 40 ng/ml) for 5 days. explored rate,...
Abstract Glioblastoma patients have a poor prognosis with low median survival rate mainly due to temozolomide (TMZ) resistance. NRF2 is an important transcript factor involved in chemotherapy resistance its ability regulate genes related the antioxidant response and prevent cell death processes, such as ferroptosis. However, relation between iron-dependent contradictory poorly understood. This study aimed analyze role of ferroptosis modulation glioblastoma cells. To this end, it was analyzed...
Abstract Several studies described the effect of human TNF-α on Schistosoma mansoni . It affects worm’s development, metabolism, egg-laying, changes in parasite´s gene expression and protein phosphorylation. Data available concerning influence hTNF-α egg-laying are controversial understanding mechanism regulation is essential combating schistosomiasis. We characterized effects vitro treatment S. adult worms with different doses (5, 20 40ng/mL) for five days. explored rate, glucose, ATP mRNA...