A5012685079- Microbial infections and disease research
- Influenza Virus Research Studies
- Pharmacovigilance and Adverse Drug Reactions
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical Practices and Patient Outcomes
- Tuberculosis Research and Epidemiology
- Respiratory viral infections research
- Electronic Health Records Systems
- Aquaculture disease management and microbiota
- Travel-related health issues
- Pharmacy and Medical Practices
- Clinical practice guidelines implementation
- Antiplatelet Therapy and Cardiovascular Diseases
- Biomedical Text Mining and Ontologies
- Viral Infectious Diseases and Gene Expression in Insects
- Virus-based gene therapy research
- Machine Learning in Healthcare
- Herpesvirus Infections and Treatments
- Insect Resistance and Genetics
- Hypothalamic control of reproductive hormones
- Healthcare cost, quality, practices
- Nonlinear Optical Materials Research
- Regulation of Appetite and Obesity
- Analytical Methods in Pharmaceuticals
- Medication Adherence and Compliance
Kagawa University Hospital
2019-2024
Kagawa University
2023
Daiichi-Sankyo (Japan)
2012-2015
Daiichi Sankyo (Germany)
2012
Nippon Veterinary and Life Science University
2003
Dionea (Switzerland)
2002
Daiichi University of Pharmacy
1998-2001
Wakayama Prefectural Tanabe High School
1982
In recent years, natural language processing (NLP) techniques have progressed, and their application in the medical field has been tested. However, use of NLP to detect symptoms from progress notes written Japanese, remains limited. We aimed 2 gastrointestinal that interfere with continuation chemotherapy-nausea/vomiting diarrhea-from using NLP, then analyze factors affecting NLP.
This study focused on the heterogeneity in progress notes written by physicians or nurses. A total of 806 days nurses from 83 randomly selected patients hospitalized Gastroenterology Department at Kagawa University Hospital January to December 2021 were analyzed. We extracted symptoms as International Classification Diseases (ICD) Chapter 18 (R00-R99, hereinafter R codes) each note using MedNER-J natural language processing software and counted one more calculate extraction rate. The R-code...
Abstract Purpose We aimed to develop a reliable identification algorithm combining diagnostic codes with several treatment factors for inpatients acute ischemic stroke (AIS) conduct pharmacoepidemiological studies using the administrative database MID‐NET® in Japan. Methods validated 11 algorithms based on 56 different (International Classification of Diseases, Tenth Revision; ICD‐10) Diagnosis Procedure Combination (DPC) data combined information AIS therapeutic procedures added as “AND”...
Non-persistence rate (defined as not remaining on treatment) in patients taking a renin angiotensin system inhibitor plus calcium channel blocker was studied three integrated 12-weeks surveys by matching separate drug combination therapy (CT) and fixed-dose (FDC). We also investigated medication adherence measured proportion of days covered using claims database. The non-persistence significantly lower FDC than CT (p = 0.0074). In the database study, higher for 3, 6, 12 months (all p <...
Abstract Purpose The purpose of this study is to evaluate the accuracy gastrointestinal (GI) perforation ICD‐10 coding in Diagnosis Procedure Combination (DPC) database and examine drug exposure risk factors for GI perforation. Methods A total 100 patients with codes were selected randomly from Kagawa University Hospital's DPC between April 2011 December 2016. Two experienced specialist physicians independently reviewed medical records classified cases as “definite A,” B,” “probable,” or “no...
Summary The pharmacodynamic effects of amoxicillin against Actinobacillus pleuropneumoniae at exposure concentration above and below minimum inhibitory (MIC) were evaluated in both vitro vivo . In , the growth morphological change A. culture medium was observed. efficacy on experimentally induced infection disease‐free pigs evaluated. Fifteen divided into three groups ( n = 5 per group). After onset clinical respiratory disease symptoms, 6 h post‐infection, sustained‐release injectable...
The bactericidal effects of amoxicillin at below minimum inhibitory concentration (MIC) against Actinobacillus pleuropneumoniae NB001 were studied in vitro and vivo. In vivo, the efficacy on experimentally induced A. infection disease-free pigs was evaluated. Nine divided into three groups all housed same room. Group I given long-acting injection 22 h prior to challenge. II also challenged but not amoxicillin. III treated. vitro, growth suppressed porcine blood with MIC. clinical signs...
Abstract Background The Medical Information Database Network (MID-NET®) in Japan is a vast repository providing an essential pharmacovigilance tool. Gastrointestinal perforation (GIP) critical adverse drug event, yet no well-established GIP identification algorithm exists MID-NET®. Methods This study evaluated 12 algorithms by combining ICD-10 codes with therapeutic procedures. Two sites contributed 200 inpatients GIP-suggestive (100 each), while third site 165 and antimicrobial...
The antimicrobial effects and pharmacokinetics of long-acting amoxicillin (150mg/ml) were investigated. Following intramuscular administration the antibiotic (7.5, 15, or 30 mg/kg) to 15 calves, bioassays conducted determine serum concentration. Minimum inhibitory concentrations for 10 strains Pasteurella multocida obtained from domestic farms measured. Clinical on calves with pneumonia caused by Results show that injections 15mg/kg 30mg/kg every 48 hrs seem be effective in treating calf Pasteurella.
Application of chicken immune sera to identification Mycoplasma species by the filter immunobinding (FIB) method was investigated. Immune against type strains 15 were prepared in chickens inoculation with concentrated organisms. Chicken sera, when absorbed a broth medium and diluted blocking solution, showed definite specificity homologous antigens FIB. The results field isolates gallisepticum M. synoviae FIB using consistent those obtained conventional tests based on biochemical properties...
雄鶏における視床下部外側核(空腹中枢)の単一ニューロン活動を慢性微小電極法により調べた結果,摂食行動と密接に関連した活動を示す2種類のニューロンが認められ,摂食行動時にtonicに活動が高進するE型と,摂食時には活動が低下するI型とに,半分ずつ分かれた.前者のE型ニューロンはtonicな活動の中にphasicな活動高進が認められ,その一部の変動は摂食動作のboutやpeckとの関連によって細分類できた.後者のI型のニューロンは探索行動時に活動が高進することが認められた.なお,両ニューロンはmulti-unitとして観察されることが多かったので隣接していると考えられた.