A5034538679- Click Chemistry and Applications
- Advanced biosensing and bioanalysis techniques
- Analytical Methods in Pharmaceuticals
- Pregnancy and Medication Impact
- Advanced Biosensing Techniques and Applications
- Antibiotics Pharmacokinetics and Efficacy
- Protein Interaction Studies and Fluorescence Analysis
- Receptor Mechanisms and Signaling
- Diabetes Treatment and Management
Menoufia University
2023
Suez Canal University
2020
Abstract Direct determination of linagliptin (LIN) using fluorimetry has been limited because LIN releases a very weak fluorescence signal. Accordingly, it should be derivatized first with fluorogenic reagent to enhance its and consequentially the sensitivity required for bioanalysis. This is description spectrofluorimetric method quantification in human plasma. The suggested exploits nucleophilic nature amino group react 4‐chloro‐7‐nitrobenzofurazan (NBD‐Cl) borate buffer at pH 8.5 yield...
The direct determination of alogliptin benzoate (ALO) using fluorescence has not yet been accomplished because ALO cannot fluoresce naturally. Accordingly, it should be derivatized first with a fluorogenic reagent to enhance the sensitivity required for its bioanalysis. This method is spectrofluorimetric assay quantification exploiting nucleophilic nature amino group react 4-chloro-7-nitrobenzofurazan (NBD-Cl) in borate buffer at pH 8.5 produce strong fluorescent compound that excited and...
Quantification of ethinylestradiol (EE) in biological matrices is challenging as it a very potent drug with low Cmax (75 pg.ml-1 ). Despite the high sensitivity fluorometric methods, detection EE was confined because its structure exhibited limited fluorescence. Therefore, must be derivatized first using fluorogenic agent to produce more fluorescence derivative achieve desired ultrasensitive bioanalysis. Here, for time, we proposed promising click fluorescent probe,...
Although the great importance of oral contraceptive agents in birth control, their existence breast milk became a cause for concern, since infant exposure to these hormones is associated with many health problems. Consequentially, developing sensitive bioanalytical method monitoring concentrations an urgent demand examine safety or risk compounds on infants. Levonorgestrel one most common under concern. Despite high sensitivity fluorometric methods, detection by them confined because its...