A new ibuprofen derivative, (E)-2-(4-isobutylphenyl)-N′-(4-oxopentan-2-ylidene) propane hydrazide (IA), was synthesized, along with its metal complexes Co, Cu, Ni, Gd, and Sm, to investigate their anti-inflammatory efficacy COX-2 inhibition potential. Comprehensive characterization, including 1H NMR, MS, FTIR, UV–vis spectroscopy, DFT analysis, were employed determine the structural configurations, revealing unique motifs for Gd/Sm (capped square antiprismatic/tricapped trigonal prismatic)...

Today, one of the most important challenges for physicians is adequate treatment infections due to multidrug resistant organism (MDR). Pseudomonas aeruginosa considered an opportunistic causing different types healthcare associated (HAIs). We aimed investigate MDR and pandrug resistance (PDR) rate in P. our region detect efflux-pump mexAB genes proposed binding interactions five categories antimicrobial agents with mexB pump. A total 180 non-duplicated strains were isolated from patients...

Quinoline-based thiazolidinone heterocycles exhibited potent activity in the field of cancer therapy. Hence, ten quinoline-based derivatives were evaluated for their anticancer through cytotoxic activity, epidermal growth factor receptor (EGFR) inhibition pathway, apoptosis investigation flow cytometric analyses, RT-PCR gene expression, vivo solid-Ehrlich carcinoma model, and finally silico approach highlighting interaction pose. Results revealed that compound 7 against HCT-116 cells with an...

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), which caused novel corona virus disease-2019 (COVID-19) pandemic, necessitated a global demand for studies related to genes and enzymes of SARS-CoV2. SARS-CoV2 infection depends on the host cell Angiotensin-Converting Enzyme-2 (ACE2) Transmembrane Serine Protease-2 (TMPRSS2), where uses ACE2 entry TMPRSS2 S protein priming. gene encodes Protease Serine-2 (TMPS2) that belongs serine protease family. There is no crystal structure...

Abstract Background Variation in host immune responses to SARS-CoV-2 is regulated by multiple genes involved innate viral response and cytokine storm emergence like IL-10 TNFa gene polymorphisms. We hypothesize that ; -592 C > A − 1082 G TNFa-308 are associated with the risk of SARS-COV2 infections clinical outcome. Methods Genotyping, laboratory radiological investigations were done 110 COVID-19 patients healthy subjects, Ismailia, Egypt. Results significant association between 592...

The emergence of untreatable drug-resistant strains

Cancer is a multifactorial disease necessitating identification of novel targets for its treatment. Inhibition Bcl-2 triggered pro-apoptotic signaling considered promising strategy cancer Within the current work, we aimed to design and synthesize new series benzimidazole- indole-based derivatives as inhibitors protein. The market pan-Bcl-2 inhibitor, obatoclax, was lead framework compound adopted structural modifications. obatoclax’s pyrrolylmethine linker replaced with straight alkylamine...

Background: World Health Organization has documented the exaggerated use of broad-spectrum antibiotics during COVID-19 pandemic raising warnings increasing antimicrobial resistance. Aim: This is an observational cross-sectional comparative study that was done to describe pattern resistance before and era explain if this affected with using different in era. Methods: Various clinical specimens from patients admitted urology, internal medicine, surgery inwards, intensive care unit neonatal ICU...

In this study, a series of coumarin derivatives, either alone or as hybrids with cinnamic acid, were synthesized and evaluated for their cytotoxicity against panel cancer cells using the MTT assay. Then, most active compounds inspected mechanism by cell-cycle analysis, RT-PCR, DNA fragmentation, Western blotting techniques. Cytotoxic results showed that compound (4) had significant cytotoxic effect HL60 (IC50 = 8.09 µM), while (8b) noticeable activity HepG2 13.14 µM). Compounds mediated via...

Breast cancer is a disease in which cells the breast divide continuously without control. There are great limitations chemotherapy. Hence, it essential to search for new therapeutics. Herein, novel series of EGFR/HER2 dual inhibitors has been designed based on hybridization thiazole and pyrazoline fragments. The synthesized compounds were screened their anti-proliferative activity against MCF-7 cell line MCF-10 normal line. Interestingly, 6e 6k showed very potent antiproliferative towards...

A novel derivative of ibuprofen and salicylaldehyde N'-(4-hydroxybenzylidene)-2-(4-isobutylphenyl) propane hydrazide (HL) was synthesized, followed by its complexation with Cu, Ni, Co, Gd, Sm. The compounds obtained were characterized 1HNMR, mass spectrometry, UV-Vis spectroscopy, FT-IR thermal analysis (DTA TGA), conductivity measurements, magnetic susceptibility measurements. results indicate that the complexes formed [Cu(L)(H2O)]Cl·2H2O, [Ni(L)2], [Co(L)2]·H2O, [Gd(L)2(H2O)2](NO3)·2H2O...

Understanding COVID-19 infection among health workers and the risk factors for adverse outcomes is important not only characterizing virus transmission patterns infection, but also preventing future of other patients reducing secondary within care settings. Our aim was to identify limit events in facilities.A total 336 HCWs from treatment hospitals took part study with varying exposure depending on job function working site. All participants were asked about infection.Among our participants,...

The rise in multidrug resistant (MDR) cases of tuberculosis (TB) has led to the need for development TB drugs with different mechanisms action. genome sequence Mycobacterium (Mtb) revealed twenty genes coding cytochrome P450s. CYP121A1 catalyzes a CC crosslinking reaction dicyclotyrosine (cYY) producing mycocyclosin and current research suggests that either is essential or overproduction cYY toxic Mtb. A series 1,4-dibenzyl-2-imidazol-1-yl-methylpiperazine derivatives were designed...

The modulatory role of primrose oil (PO) supplementation enriched with γ-linolenic acid and D/L-alpha tocopherol acetate against a carbon tetrachloride (CCl4)-induced liver damage model was assessed in this study. Twenty male Albino rats were divided into four groups. control group received corn orally. PO 10 mg/kg P O CCl4 2 mL/kg orally PO/CCl4 group; relative weight recorded. Serum enzymes, hepatic malondialdehyde (MDA), reduced glutathione (GSH) the expression tumor necrosis factor-alpha...

Background. COVID-19 infection is more likely to be acquired and transmitted by healthcare workers (HCWs). Furthermore, they serve as role models for communities in terms of vaccination attitudes. As a result, HCWs’ reluctance vaccinate could have significant impact on pandemic containment efforts. Aim. To characterize the current vaccine approval situation among determine most reason agreement or disagreement with vaccination. Methods. This cross-sectional design included 451 HCWs from...

A high-performance liquid chromatographic method has been developed for the simultaneous analysis of benzonatate (BNZ), diphenhydramine hydrochloride (DPH), guaifenesin (GFN), and phenylephrine (PEP). The separation was achieved using a Thermo C18 reversed-phase column (250 mm × 4.6 ID, particle size 5 µ). Dual mode gradient elution used UV detection carried out at 222 nm. specific stability indicating as conditions provided adequate degradation products. showed good linearity in range...

Quantification of ethinylestradiol (EE) in biological matrices is challenging as it a very potent drug with low Cmax (75 pg.ml-1 ). Despite the high sensitivity fluorometric methods, detection EE was confined because its structure exhibited limited fluorescence. Therefore, must be derivatized first using fluorogenic agent to produce more fluorescence derivative achieve desired ultrasensitive bioanalysis. Here, for time, we proposed promising click fluorescent probe,...

Imidazole is a planner heterocyclic five-member ring with 3C and 2N atom in N present 1st 3rd positions. The imidazole constituent of many important natural products, including purine, histidine, nucleic acid. Being polar ionizable aromatic compound, it improves pharmacokinetic characteristics lead molecules thus used as drug to optimize solubility bioavailability parameters proposed poorly soluble molecules. Derivatives have occupied critical place the field medicinal chemistry. nucleus an...

Tuberculosis (TB) is the ninth leading cause of death worldwide and from a single infectious agent, ranking above HIV/AIDS with 6.3 million new cases TB reported in 2016.TB an air-borne disease associated aerobic bacterium Mycobacterium tuberculosis (Mtb), which mainly infects lungs.Aerosolization diseased pulmonary secretions, by coughing, sneezing speaking, discharge Mtb bacilli into atmosphere.Infected aerosol droplet nuclei sized 1-μm are largely trapped upper nasal passages or expelled...