A5021313285- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Intraocular Surgery and Lenses
- Retinal Diseases and Treatments
- Congenital heart defects research
- Distributed and Parallel Computing Systems
- Ocular Surface and Contact Lens
- Cancer-related molecular mechanisms research
- Real-Time Systems Scheduling
- Circular RNAs in diseases
- Sinusitis and nasal conditions
- Ocular Diseases and Behçet’s Syndrome
- Peer-to-Peer Network Technologies
- RNA Research and Splicing
- Antifungal resistance and susceptibility
- melanin and skin pigmentation
- Cell Adhesion Molecules Research
- Expert finding and Q&A systems
- Retinal and Macular Surgery
- Genetics and Neurodevelopmental Disorders
- COVID-19 and healthcare impacts
- Infectious Diseases and Mycology
- Cloud Computing and Resource Management
University College London
2023-2025
Moorfields Eye Hospital
2025
Johns Hopkins University
2024
Johns Hopkins Medicine
2024
Institute of Ophthalmology
2024
Manchester Royal Eye Hospital
2020-2023
Manchester University NHS Foundation Trust
2020-2023
University of Manchester
2021-2022
People's Hospital of Xinjiang Uygur Autonomous Region
2022
Genomics (United Kingdom)
2021
Importance Understanding the pathogenic mechanisms of Fuchs endothelial corneal dystrophy (FECD) could contribute to developing gene-targeted therapies. Objective To investigate associations between demographic data and age at first keratoplasty in a genetically refined FECD cohort. Design, Setting, Participants This retrospective cohort study recruited 894 individuals with Moorfields Eye Hospital (London) General University (Prague) from September 2009 July 2023. Ancestry was inferred...
Unlike other types of breast cancer, triple negative cancer (TNBC) does not respond to therapies targeting human epidermal growth factor receptor-2 (HER2) or hormone therapy, and the prognosis patients with TNBC is usually poor. The role long non-coding RNA (lncRNA) small nucleolar host gene 10 (SNHG10) has been investigated in many but its unknown. This study aimed explore SNHG10 context doxorubicin treatment, a common therapy for TNBC. Analysis TCGA dataset revealed downregulation was...
Laminin N-terminus (LaNt) α31 is a relatively unstudied protein derived from the laminin α3 gene but structurally similar to netrins. LaNt has, date, been investigated only in two-dimensional (2D) keratinocyte culture where it influences cell migration and adhesion, processes integral wound repair. Here we distribution ocular surface epithelium, during limbal stem activation, corneal healing.
Abstract Here, we demonstrate the utility of optical genome mapping (OGM) to interrogate Fuchs endothelial corneal dystrophy (FECD)-associated intronic TCF4 triplet repeat (termed CTG18.1) and gain novel insights into tissue-specific nature disease. Genomic DNA (gDNA) samples derived from peripheral blood leukocytes primary cells (CECs) were analysed by OGM. Concurrently, all genotyped standard PCR-based methods classify their expansion status. Individuals with one or more CTG18.1-expanded...
Purpose To evaluate the application of Retrieval-Augmented Generation (RAG), a technique that combines information retrieval with text generation, to benchmark performance open-source and proprietary generative large language models (LLMs) in medical question-answering tasks within ophthalmology domain. Methods Our dataset comprised 260 multiple-choice questions sourced from two question-answer banks designed assess ophthalmic knowledge: American Academy Ophthalmology's Basic Clinical...
As the primary burden of treating COVID-19 patients began to ease in United Kingdom, ophthalmology clinic volume within National Health Service has since recovered. Alarmingly, rate non-attendance remains higher than pre-pandemic level.The purpose was assess how perceived risk contracting coronavirus disease 2019 (COVID-19) influences willingness individuals with sight-threatening macular conditions attend intravitreal anti-vascular endothelial growth factor (anti-VEGF) injection...
A new server-decentralized Internet architecture based on Jabber for robot remote control is proposed in order to have high availability, performance, scalability, fault tolerance and security. Four components of the architecture: operators, robots, transfer servers data-keeper are defined functioned. The robot-controlling data/robot state data packed with XML stanzas delivered addressed robot/operator through streams. In test its implemented instanced as a simulation system Puma560 robot....
Combined use of photodynamic therapy (PDT) with intravitreal anti-vascular endothelial growth factors (anti-VEGF) agents, such as ranibizumab (IVR) or aflibercept (IVA), has been shown to be effective for treating polypoidal choroidal vasculopathy (PCV). However, it is currently not well established which anti-VEGF agent provides superior outcomes performing combination therapy. The present study compares the visual and re-treatment burden PDT either IVR IVA in a European cohort patients...
To describe the real-world outcomes of photodynamic therapy (PDT) as a rescue in eyes with polypoidal choroidal vasculopathy (PCV) refractory to anti-vascular endothelial growth factor (VEGF) monotherapy British cohort patients.This is retrospective chart review 53 PCV. Based on timing PDT, were stratified into two groups (9 Initial-PDT group, 44 Deferred group). The number anti-VEGF injections/year and best corrected visual acuity (BCVA) before after PDT analysed. Multivariate regression...
Importance: Understanding the pathogenic mechanisms of Fuchs endothelial corneal dystrophy (FECD) is essential for developing gene-targeted therapies. Objective: To investigate associations between demographic data and age at first keratoplasty in a large genetically refined FECD cohort. Design, Setting, Participants: This retrospective cohort study recruited 894 individuals with Moorfields Eye Hospital (London) General University (Prague). Ancestry was inferred from genome-wide SNP array...
Abstract Purpose To characterise the phenotype and genotype of concurrent keratoconus Fuchs endothelial corneal dystrophy (KC + FECD). Methods We recruited 20 patients with KC FECD for a retrospective observational case series from United Kingdom Czech Republic. compared eight parameters shape (Pentacam, Oculus) two groups age‐matched controls who had either isolated (KC) or FECD. genotyped probands an intronic triplet TCF4 repeat expansion (CTG18.1) ZEB1 variant c.1920G >T p.(Gln640His)....
Liu, Siyin MBChB, MRes; Yagan, Ali MD, MSc, FRCOphthEditor(s): Avery, Robert DO; Golnik, Karl C. MD; Froment, Caroline PhD; Wang, An-Guor MD Author Information