A5054254122- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Pancreatic function and diabetes
- Neuroendocrine Tumor Research Advances
- Monoclonal and Polyclonal Antibodies Research
- RNA modifications and cancer
- Protein Tyrosine Phosphatases
- Cancer, Hypoxia, and Metabolism
- Nutritional Studies and Diet
- Metabolism, Diabetes, and Cancer
- Thermochemical Biomass Conversion Processes
- Adipose Tissue and Metabolism
- Gastrointestinal motility and disorders
- Diet, Metabolism, and Disease
- Carbohydrate Chemistry and Synthesis
- Lignin and Wood Chemistry
- Sirtuins and Resveratrol in Medicine
- Cancer-related Molecular Pathways
- Lung Cancer Treatments and Mutations
- Diabetes and associated disorders
- Immunotherapy and Immune Responses
- Obesity, Physical Activity, Diet
- Advanced Cellulose Research Studies
- ATP Synthase and ATPases Research
- Consumer Attitudes and Food Labeling
Luxembourg Institute of Health
2024
Holy Spirit University of Kaslik
2021-2024
University of Balamand
2024
University of Groningen
2024
Technological University Dublin
2024
Agency for Science, Technology and Research
2015-2017
Singapore Institute for Clinical Sciences
2015-2017
Unité de Glycobiologie Structurale et Fonctionnelle
2001-2015
Université Lille Nord de France
2001-2015
Breast Cancer Care
2012
Sialyl-Tn is a carbohydrate antigen overexpressed in several epithelial cancers, including breast cancer, and usually associated with poor prognosis. synthesized by CMP-Neu5Ac:GalNAcα2,6-sialyltransferase: CMP-Neu5Ac: R-GalNAcα1-O-Ser/Thr α2,6-sialyltransferase (EC 2.4.99.3) (ST6GalNAc I), which transfers sialic acid residue α2,6-linkage to the GalNAcα1-O-Ser/Thr structure. However, established cancer cell lines express neither ST6GalNAc I nor sialyl-Tn. We have previously shown that stable...
Changes in the composition of glycans added to glycoproteins and glycolipids are characteristic change malignancy. Sialyl-Tn (STn) is expressed by 25–30% breast carcinomas but its expression on normal tissue highly restricted. an O-linked disaccharide that can be carried various glycoproteins. One such glycoprotein MUC1 vast majority carcinomas. Both STn have been considered as targets for immunotherapy cancer patients. Here we used different immunogens target transgenic mouse model tumour...
Individuals who are born small for gestational age (SGA) have a risk to develop various metabolic diseases during their life course. The biological memory of the prenatal state growth restricted individuals may be reflected in epigenetic alterations stem cell populations. Mesenchymal cells (MSCs) from Wharton's jelly umbilical cord tissue multipotent, and we generated primary MSC isolates SGA normal neonates, which were subsequently differentiated into adipocytes. We established chromatin...
Increasing energy expenditure through brown adipocyte recruitment is a promising approach to combat obesity. We report here the comprehensive profiling of epigenome and transcriptome throughout lineage commitment differentiation C3H10T1/2 mesenchymal stem cell line into adipocytes. Through direct comparison datasets from differentiating white adipocytes, we systematically identify stage- lineage-specific coding genes, lncRNAs microRNAs. Utilizing chromatin state maps, also define enhancers,...
Obesity develops when caloric intake exceeds metabolic needs. Promoting energy expenditure represents an attractive approach in the prevention of this fast-spreading epidemic. Here, we report a novel pharmacological strategy which natural compound, narciclasine (ncls), attenuates diet-induced obesity (DIO) mice by promoting expenditure. Moreover, ncls promotes fat clearance from peripheral tissues, improves blood parameters DIO mice, and protects these loss voluntary physical activity....
Since 2019, the world is confronting COVID-19 public health crisis that deeply impacted all aspects of life, from sector to economy. Despite advancement research targeting pandemic containment measures, more strategies are still needed alleviate burden caused by this novel disease. In particular, optimal nutrition was proposed as a possible mitigating factor in context COVID-19. Indeed, light shed on balanced diets, such Mediterranean diet, which present finest nutritional quality support...
Although the Mediterranean Diet has been acknowledged as best overall diet for year 2020, it seen a decrease in its adherence over past years. This is due to several reasons, one of which gradual shift more westernized with all influences that occur especially on university students whose dietary choices set path future habits. The aim this study check level and frequency breakfast consumption among Lebanon whether they are influenced by sociodemographic, anthropometric, knowledge, or...
This study was undertaken to clarify the controversy in literature about pancreatic localization of cholecystokinin (CCK) CCK A and B receptors. With antibodies used by other investigators, we first established their specificity Western blotting, indirect immunofluorescence, confocal microscopy with each antibody's peptide antigen. Co-localization assays between receptors hormones insulin, glucagon, somatostatin revealed that RAbs 1122 R1-2 recognized insulin glucagon cells rat, pig, human...
The chemotherapeutic drug doxorubicin and the anti-proliferative long-acting somatostatin analogue octreotide, both used in cancer treatment, have been shown to increase expression of p53 tumour suppressor protein. In present study, we demonstrate by Western-blot analysis that, addition protein, these molecules were able induce a shorter protein with an apparent molecular mass 40 kDa (p40), recognized antibodies raised against N-terminus p53. This induction was tumoral non-tumoral cells did...
An impairment of respiratory function has been demonstrated in dairy farmers. The objective this study was to evaluate the relationship allergy farmers a longitudinal conducted Doubs (France). A cohort male constituted 1990 re-evalued 1995. Subjects completed medical and occupational questionnaire, spirometry test both 1995, 1995 they were also subjected immunological tests. Relationships between variables studied by multiple linear regression model adjusted for age, smoking status,...