A5016881875- Neuroinflammation and Neurodegeneration Mechanisms
- Parathyroid Disorders and Treatments
- Inflammation biomarkers and pathways
- Caveolin-1 and cellular processes
- Apelin-related biomedical research
- Neurological Disease Mechanisms and Treatments
- Cerebrovascular and genetic disorders
- Multiple Sclerosis Research Studies
- Barrier Structure and Function Studies
- Sphingolipid Metabolism and Signaling
- Genetic Syndromes and Imprinting
- Immune cells in cancer
ETH Zurich
2021-2024
University Hospital of Zurich
2021-2024
University of Zurich
2021-2024
PES University
2016
Pericytes regulate the development of organ-specific characteristics brain vasculature such as blood-brain barrier (BBB) and astrocytic end-feet. Whether pericytes are involved in control leukocyte trafficking adult central nervous system (CNS), a process tightly regulated by CNS vasculature, remains elusive. Using pericyte-deficient mice (Pdgfbret/ret ), we show that limit infiltration into during homeostasis autoimmune neuroinflammation. The permissiveness toward Pdgfbret/ret inversely...
Microglial activity is needed to halt nascent vascular calcification.
Calcification of the cerebral microvessels in basal ganglia absence systemic calcium and phosphate imbalance is a hallmark primary familial brain calcification (PFBC), rare neurodegenerative disorder. Mutation genes encoding for sodium-dependent transporter 2 (SLC20A2), xenotropic polytropic retrovirus receptor 1 (XPR1), platelet-derived growth factor B (PDGFB), beta (PDGFRB), myogenesis regulating glycosidase (MYORG), junctional adhesion molecule (JAM2) are known to cause PFBC....
Brain calcification, the ectopic mineral deposits of calcium phosphate, is a frequent radiological finding and diagnostic criterion for primary familial brain calcification. We previously showed that microglia curtail growth small vessel calcification via triggering receptor expressed in myeloid 2 (TREM2) Pdgfb ret/ret mouse model Because boosting TREM2 function using activating antibodies has been shown to be beneficial other disease conditions by aiding microglial clearance diverse...