A5075405411- Barrier Structure and Function Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Histiocytic Disorders and Treatments
- Nitric Oxide and Endothelin Effects
- Intracranial Aneurysms: Treatment and Complications
- Extracellular vesicles in disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune responses and vaccinations
- Multiple Sclerosis Research Studies
- Axon Guidance and Neuronal Signaling
- Renin-Angiotensin System Studies
- Neurological Disorders and Treatments
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- RNA regulation and disease
- Neurosurgical Procedures and Complications
- Gynecological conditions and treatments
- Neurological Disease Mechanisms and Treatments
- Cardiovascular Health and Disease Prevention
- Receptor Mechanisms and Signaling
- Parasitic infections in humans and animals
- Cerebrovascular and Carotid Artery Diseases
- Neurogenesis and neuroplasticity mechanisms
University of Pecs
2012-2023
University of Zurich
2019-2021
University Hospital of Zurich
2019-2021
ETH Zurich
2019-2021
Pericytes regulate the development of organ-specific characteristics brain vasculature such as blood-brain barrier (BBB) and astrocytic end-feet. Whether pericytes are involved in control leukocyte trafficking adult central nervous system (CNS), a process tightly regulated by CNS vasculature, remains elusive. Using pericyte-deficient mice (Pdgfbret/ret ), we show that limit infiltration into during homeostasis autoimmune neuroinflammation. The permissiveness toward Pdgfbret/ret inversely...
Abstract Brain endothelium possesses several organ-specific features collectively known as the blood-brain barrier (BBB). In addition, trafficking of immune cells in healthy central nervous system (CNS) is tightly regulated by CNS vasculature. autoimmune diseases such multiple sclerosis (MS), these homeostatic mechanisms are overcome autoreactive lymphocyte entry into causing inflammatory demyelinating immunopathology. Previous studies have shown that pericytes regulate development...
Rationale Nebivolol is known to have beta-1 blocker activity, but it was also suggested that elicits relaxation of the peripheral arteries in part via release nitric oxide (NO). However, effect nebivolol on vasomotor tone cerebral still unclear. Objective To assess effects diameter isolated rat basilar (BA) control, presence inhibitors signaling pathways know action and hemolysed blood. Methods Results Vasomotor responses were measured by videomicroscopy intracellular Ca2+ Fura-2 AM...
Neurodegenerative diseases (ND) are characterized by progressive loss of neuronal function. Mechanisms ND pathogenesis incompletely understood, hampering the development effective therapies. Langerhans cell histiocytosis (LCH) is an inflammatory neoplastic disorder caused hematopoietic progenitors expressing MAPK activating mutations that differentiate into senescent myeloid cells drive lesion formation. Some patients with LCH subsequently develop and incurable neurodegeneration (LCH-ND)....
During acute subarachnoid hemorrhage, blood is hemolyzed, which followed by a significant cerebrovascular spasm resulting in serious clinical condition. Interestingly, however, the direct vasomotor effect of perivascular hemolyzed (HB) has not yet been characterized, preventing assessment contribution vasoconstrictor mechanisms deriving from brain tissue and/or and development possible treatments. We hypothesized that HB reduces diameter cerebral arteries (i.e., basilar artery [BA]; middle...
Objective. Cerebrovascular hemorrhage (stroke, trauma) is followed by increased vascular resistance. We hypothesized that extraluminal hemolysed blood (HeBl) increases the tone and affects vasomotor responses of isolated cerebral arteries. Methods. Rat basilar arteries (BA) were placed in a vessel chamber. In control, presence after washout HeBl vessels studied to acetylcholine (ACh), sodium-nitroprusside (SNP), nifedipine (Nif) CO2, then passive diameter (PD) was determined Ca2+-free Krebs...
Experimental and clinical studies have revealed that the antiarrhythmic antihypertensive, highly selective β1‐adrenerg receptor blocker, nebivolol elicits dilations in peripheral arteries, which a role for nitric oxide (NO) has been implicated. However, its effect on diameter of cerebral vessels not investigated. We hypothesized increases isolated arteries. Basilar arteries (BA) were from male Wistar rats mounted into isotonic myograph chamber. Diameters measured by video‐microscopy response...
Angiotensin II (Ang II) via activating angiotensin type 1 receptors (AT R) is a potent vasoconstrictor, whereas recent studies suggest role for AT 2 R in the modulation of vasomotor tone (VT). There are few data, however regarding aging‐induced changes Ang II‐induced VT. We hypothesized that from newborn to senescence age there substantial VT, mediated by and/or R. Changes isometric force carotid arteries (CA) (8 days: 8d), young (2–9 months[m]: 2–9m), adult (12–20m) and (20–30m) rats were...
The vasoconstrictor mechanisms in acute intracerebral hemorrhage have not been fully clarified. We hypothesized that perivascular hemolysed blood (HB) has substantial effects on the tone and vasomotor responses of isolated cerebral arteries. Basilar artery (BA) from male rats was placed a pressure‐myograph chamber. diameters vessels were measured by videomicroscopy. After administration HB function studied to acetylcholine (Ach), sodium‐nitroprusside (SNP), nifedipine (Nife) CO 2 , which...