A5058609187- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Click Chemistry and Applications
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Aortic Disease and Treatment Approaches
- Cardiac and Coronary Surgery Techniques
- Chemical Synthesis and Analysis
- Pregnancy-related medical research
- Neurological Complications and Syndromes
- Peptidase Inhibition and Analysis
- Pregnancy and Medication Impact
- Cardiac Valve Diseases and Treatments
Materials Center Leoben (Austria)
2025
Universität Innsbruck
2020-2024
Medical University of Graz
2023
Innsbruck Medical University
2020
A major challenge in the field of RNA chemistry is identification selective and quantitative conversion reactions on that can be used for tagging any other tool development. Here, we introduce metal-free diazotransfer native containing an aliphatic primary amino group using diazotizing reagent fluorosulfuryl azide (FSO2 N3 ). The reaction provides corresponding azide-modified nearly quantitatively yields without affecting nucleobase groups. obtained azido-RNA then further processed utilizing...
Abstract During pregnancy, substantial alterations in cerebral plasticity, vascular remodeling and neuronal growth occur the maternal brain. We investigated whether concentrations of selected neurodiagnostic biomarkers cerebrospinal fluid women with preeclampsia/HELLP syndrome differ from those healthy controls using enzyme-linked immunosorbent assay technique. found that t au protein (p = 0.016) phospho-tau/tau ratio < 0.001) were significantly lower 39 preeclamptic compared to 44 during...
Hydrolysis-resistant RNA-peptide conjugates that mimic peptidyl-tRNAs are frequently needed for structural and functional studies of protein synthesis in the ribosome. Such accessible by chemical solid-phase synthesis, allowing utmost flexibility both peptide RNA sequence. Commonly used protection group strategies, however, have severe limitations with respect to generating characteristic Nα-formylmethionyl terminus because formyl conjugate synthesized at solid support is easily cleaved...
Abstract Hydrolysis‐resistant RNA‐peptide conjugates that mimic peptidyl‐tRNAs are often required for structural and functional studies of protein synthesis at the ribosome. These can be synthesized by solid‐phase chemical synthesis, which allows maximum flexibility in both peptide RNA sequence. The commonly used strategy is based on (3’‐ N ‐aminoacyl)‐3’‐amino‐3’‐deoxyadenosine solid supports, already contain first C‐terminal amino acid target peptidyl chain. This a limitation sense...
We report the surgical repair of a penetrating aortic ulcer in distal ascending aorta close to brachiocephalic trunk, by supracoronary and hemiarch replacement via full sternotomy. The procedure is performed under moderate hypothermia with bilateral antegrade cerebral perfusion.
A major challenge in the field of RNA chemistry is identification selective and quantitative conversion reactions on that can be used for tagging any other tool development. Here, we introduce metal-free diazotransfer native containing an aliphatic primary amino group using diazotizing reagent fluorosulfuryl azide (FSO
Abstract To evaluate changes in concentrations of selected biomarkers, neurotrophic factors, and growth factors the cerebrospinal fluid during pregnancy. A prospective observational study was conducted 32 pregnant women undergoing gynecological obstetrical surgery under spinal anesthesia a university hospital. Beta-amyloid(1–42) beta-amyloid(1–40) peptides, brain-derived factor, glial cell line-derived vascular endothelial factor were analyzed using an enzyme-linked immunosorbent assay....